Enzymes and Protein Markers:

Else Marie Vestergaard, Hans Wolf, and Torben F. Ørntoft

Increased concentrations of genotype-interpreted Ca 19-9 in urine of bladder cancer patients mark diffuse atypia of the urothelium
Clin Chem 1998 44: 197-204. [Abstract] [Full Text] [PDF]  

Geralyn M. Lambert-Messerlian, Jacob A. Canick, Dimitrios N. Melegos, and Eleftherios P. Diamandis

Increased concentrations of prostate-specific antigen in maternal serum from pregnancies affected by fetal Down syndrome
Clin Chem 1998 44: 205-208. [Abstract] [Full Text] [PDF]  

Norbert Genser, Peter Lechleitner, Josef Maier, Franz Dienstl, Erika Artner-Dworzak, Bernd Puschendorf, and Johannes Mair

Rebound increase of plasminogen activator inhibitor type 1 after cessation of thrombolytic treatment for acute myocardial infarction is independent of type of plasminogen activator used
Clin Chem 1998 44: 209-214. [Abstract] [Full Text] [PDF]  

Makoto Kawai, Yukichi Hara, Tetsuo Kubota, Kiyoko Shiba, and Seijin Hosaki

A family with high serum leucine aminopeptidase activity derived from a novel variant CD13
Clin Chem 1998 44: 215-220. [Abstract] [Full Text] [PDF]  

Mamoru Nakanishi, Kousei Yoh, Kagehiro Uchida, Souji Maruo, and Akira Matsuoka

Improved method for measuring tartrate-resistant acid phosphatase activity in serum
Clin Chem 1998 44: 221-225. [Abstract] [Full Text] [PDF]  

Luis F. Pérez and J. Carlos Tutor

Assay of ß-N-acetylhexosaminidase isoenzymes in different biological specimens by means of determination of their activation energies
Clin Chem 1998 44: 226-231. [Abstract] [Full Text] [PDF]  

Jian Tu, Zhiguang Yu, and Yen-Ho Chu

Combinatorial search for diagnostic agents: Lyme antibody H9724 as an example
Clin Chem 1998 44: 232-238. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Cornelia Haug, Wolfgang Koenig, Martin Hoeher, Matthias Kochs, Vinzenz Hombach, Adolf Gruenert, and Hans Osterhues

Direct enzyme immunometric measurement of plasma big endothelin-1 concentrations and correlation with indicators of left ventricular function
Clin Chem 1998 44: 239-243. [Abstract] [Full Text] [PDF]  

Girish N. Ranadive, Jehangir S. Mistry, Kalyani Damodaran, M. Javad Khosravi, Anastasia Diamandi, Terry Gimpel, V. Daniel Castracane, S. Patel, and Frank Z. Stanczyk

Rapid, convenient radioimmunoassay of estrone sulfate
Clin Chem 1998 44: 244-249. [Abstract] [Full Text] [PDF]  

Javier Rodríguez-García, Jesús R. Requena, and Santiago Rodríguez-Segade

Increased concentrations of serum pentosidine in rheumatoid arthritis
Clin Chem 1998 44: 250-255. [Abstract] [Full Text] [PDF]  

Kazuyoshi Ikeda, Yuichiro Sakamoto, Yukie Kawasaki, Takehiro Miyake, Kimikazu Tanaka, Takeyoshi Urata, Yoshiaki Katayama, Shoichi Ueda, and Seikoh Horiuchi

Determination of glycated albumin by enzyme-linked boronate immunoassay (ELBIA)
Clin Chem 1998 44: 256-263. [Abstract] [Full Text] [PDF]  

Molecular Pathology and Genetics:

Arve Ulvik, Jicun Ren, Helga Refsum, and Per Magne Ueland

Simultaneous determination of methylenetetrahydrofolate reductase C677T and factor V G1691A genotypes by mutagenically separated PCR and multiple-injection capillary electrophoresis
Clin Chem 1998 44: 264-269. [Abstract] [Full Text] [PDF]  

Jan-Gowth Chang, Yuh-Jyh Jong, Wen-Pin Wang, Jyh-Chwan Wang, Chaur-Jong Hu, Man-Chi Lo, and Chih-Peng Chang

Rapid detection of a recombinant hotspot associated with Charcot–Marie–Tooth disease type 1A duplication by a PCR-based DNA test
Clin Chem 1998 44: 270-274. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Robert F. Smith, Hugh M. Mather, and Gordon A. Ellard

Assessment of simple colorimetric procedures to determine smoking status of diabetic subjects
Clin Chem 1998 44: 275-280. [Abstract] [Full Text] [PDF]  

Joanne V. Mei, W. Harry Hannon, Trudy L. Dobbs, Carol J. Bell, Cathy Spruill, and Marta Gwinn

Radioimmunoassay for monitoring zidovudine in dried blood spot specimens
Clin Chem 1998 44: 281-286. [Abstract] [Full Text] [PDF]  

Edward D. Clarkson, David Lesser, and Buddha D. Paul

Effective GC-MS procedure for detecting iso-LSD in urine after base-catalyzed conversion to LSD
Clin Chem 1998 44: 287-292. [Abstract] [Full Text] [PDF]  

Immunology:

Wayne H. Schrier, Ronald J. Schoengold, Josefina T. Baker, Joyce L. Norell, Corey L. Jaseph, Yelena Okin, Jeam Y. Doe, and Howard Chandler

Development of FlexSure^® HP—an immunochromatographic method to detect antibodies against Helicobacter pylori
Clin Chem 1998 44: 293-298. [Abstract] [Full Text] [PDF]  

Charles Y. Cheung, David J. Green, Gerald J. Litt, and James A. Laugharn, Jr.

High-pressure-mediated dissociation of immune complexes demonstrated in model systems
Clin Chem 1998 44: 299-303. [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Wei-Li Di, Aban Kadva, Ovrang Djahanbakhch, and Robert Silman

Radioimmunoassay of bound and free melatonin in plasma
Clin Chem 1998 44: 304-310. [Abstract] [Full Text] [PDF]  

Frank Frantzen, Arne Ludvig Faaren, Ingrid Alfheim, and Arne Kristian Nordhei

Enzyme conversion immunoassay for determining total homocysteine in plasma or serum
Clin Chem 1998 44: 311-316. [Abstract] [Full Text] [PDF]  

Test Utilization and Outcome:

Andrew A. Reilly, Ronald Bellisario, and Kenneth A. Pass

Multivariate discrimination for phenylketonuria (PKU) and non-PKU hyperphenylalaninemia after analysis of newborns' dried blood-spot specimens for six amino acids by ion-exchange chromatography
Clin Chem 1998 44: 317-326. [Abstract] [Full Text] [PDF]  

Laboratory Management:

Arja Virtanen, Veli Kairisto, Kerttu Irjala, Allan Rajamäki, and Esa Uusipaikka

Regression-based reference limits and their reliability: example on hemoglobin during the first year of life
Clin Chem 1998 44: 327-335. [Abstract] [Full Text] [PDF]  

Case Reports:

Bernard L. Croal, Alastair C. A. Glen, Christopher J. G. Kelly, and Robert W. Logan

Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy
Clin Chem 1998 44: 336-340. [Abstract] [Full Text] [PDF]  

Technical Briefs:

David J. Green, Gerald J. Litt, and James A. Laugharn, Jr.

Use of High Pressure to Accelerate Antibody:Antigen Binding Kinetics Demonstrated in an HIV-1 p24:Anti-HIV-1 p24 Assay
Clin Chem 1998 44: 341-342. [Extract] [Full Text] [PDF]  

Huub P. J. Willems, Gerard M. J. Bos, Wim B. J. Gerrits, Martin den Heijer, Stephanie Vloet, and Henk J. Blom

Acidic Citrate Stabilizes Blood Samples for Assay of Total Homocysteine
Clin Chem 1998 44: 342-345. [Extract] [Full Text] [PDF]  

Ching-Wan Lam, Chi-Kong Lai, and Yan-Wo Chan

Simultaneous Fluorescence Detection of Fecal Urobilins and Porphyrins by Reversed-Phase High-Performance Thin-Layer Chromatography
Clin Chem 1998 44: 345-346. [Extract] [Full Text] [PDF]  

Alan B. Storrow, Alexander V. Hernandez, and John A. Norton

Nalmefene and the Urine Opiate Screen
Clin Chem 1998 44: 346-348. [Extract] [Full Text] [PDF]  

Jan Danneberg, André P. Abbes, Ben J. M. Bruggeman, Henk Engel, Jan Gerrits, and Alexander Martens

Reliable Genotyping of the G-20210-A Mutation of Coagulation Factor II (Prothrombin)
Clin Chem 1998 44: 349-351. [Extract] [Full Text] [PDF]  

Freek W. C. Roelandse, Nico van der Zwart, Jan H. Didden, Jenny van Loon, and John H. M. Souverijn

Detection of CSF Leakage by Isoelectric Focusing on Polyacrylamide Gel, Direct Immunofixation of Transferrins, and Silver Staining
Clin Chem 1998 44: 351-353. [Extract] [Full Text] [PDF]  

Joseph E. Zerwekh and Charles Y. C. Pak

Lack of Skeletal Lead Accumulation During Calcium Citrate Supplementation
Clin Chem 1998 44: 353-354. [Extract] [Full Text] [PDF]  

Didier Chevenne, Annick Letailleur, François Trivin, and Dominique Porquet

Effect of Hemolysis on the Concentration of Insulin in Serum Determined by RIA and IRMA
Clin Chem 1998 44: 354-356. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Diego Franciotta, Enrica Di Paolo, Carmine Tinelli, and Gianvico Melzi d'Eril

Protein in Cerebrospinal Fluid of Patients with Alzheimer Disease
Clin Chem 1998 44: 357-358. [Extract] [Full Text] [PDF]  

Christlieb Haller, Hugo A. Katus, Fred S. Apple, and Scott W. Sharkey

Expression of Cardiac Troponin T in Skeletal Muscle
Clin Chem 1998 44: 358-359. [Extract] [Full Text] [PDF]  

Clara Peña, Cecília Martínez-Brú, Rosa Homs, Teresa Planella, and Mariano Cortés

Effect of Plasma Replacement Therapy on Determinations of Urine Protein Concentration
Clin Chem 1998 44: 359-360. [Extract] [Full Text] [PDF]  

Michèle Vernet, Jean-Yves Le Gall, Elanine W. Gunter, and Sharon M. McDonnell

Transferrin Saturation and Screening of Genetic Hemochromatosis • Representatives of the CDC respond:
Clin Chem 1998 44: 360-362. [Extract] [Full Text] [PDF]  

Salim Fredericks, Gurcharan Merton, Maria-Jose Lerena, David W. Holt, Geza S. Bodor, Fred S. Apple, and Ellen M. Voss

Markers of Myocardial Damage
Clin Chem 1998 44: 362-365. [Extract] [Full Text] [PDF]  

Book Reviews:

Thomas G. Rosano

Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning, 2nd ed. Matthew J. Ellenhorn, Seth Schonwald, Gary Ordog, and Jonathan Wasserberger. Baltimore, MD: Williams and Wilkins, 1997, 2047 pp., $199, ISBN 0–683-30031–8.
Clin Chem 1998 44: 366. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

The Clinical Chemist
Clin Chem 1998 44: 367-368. [Extract] [Full Text] [PDF]  

TDM Conference:

Leslie M. Shaw and Michael Oellerich

The Role of Therapeutic Drug Monitoring in Disease Management: Introduction
Clin Chem 1998 44: 369. [Extract] [Full Text] [PDF]  

Gerald E. Schumacher and Judith T. Barr

Total testing process applied to therapeutic drug monitoring: impact on patients' outcomes and economics
Clin Chem 1998 44: 370-374. [Abstract] [Full Text] [PDF]  

Larry D. Bowers

Analytical goals in therapeutic drug monitoring
Clin Chem 1998 44: 375-380. [Abstract] [Full Text] [PDF]  

Leslie M. Shaw, Bruce Kaplan, and Kenneth L. Brayman

Prospective investigations of concentration–clinical response for immunosuppressive drugs provide the scientific basis for therapeutic drug monitoring
Clin Chem 1998 44: 381-387. [Abstract] [Full Text] [PDF]  

Yuen Yi Hon and William E. Evans

Making TDM work to optimize cancer chemotherapy: a multidisciplinary team approach
Clin Chem 1998 44: 388-400. [Abstract] [Full Text] [PDF]  

David W. Bates, Steven J. Soldin, Petrie M. Rainey, and Joseph N. Micelli

Strategies for physician education in therapeutic drug monitoring
Clin Chem 1998 44: 401-407. [Abstract] [Full Text] [PDF]  

Lutz Binder, Xaver Schiel, Claudia Binder, Cristina Fernandes Almeida Menke, Silke Schüttrumpf, Victor W. Armstrong, Michael Unterhalt, Norbert Erichsen, Wolfgang Hiddemann, and Michael Oellerich

Clinical outcome and economic impact of aminoglycoside peak concentrations in febrile immunocompromised patients with hematologic malignancies
Clin Chem 1998 44: 408-414. [Abstract] [Full Text] [PDF]  

Philip D. Walson

Therapeutic drug monitoring in special populations
Clin Chem 1998 44: 415-419. [Abstract] [Full Text] [PDF]  

Ronald Lieberman, James A. Crowell, Ernest T. Hawk, Charles W. Boone, Caroline C. Sigman, and Gary J. Kelloff

Development of new cancer chemoprevention agents: role of pharmacokinetic/pharmacodynamic and intermediate endpoint biomarker monitoring
Clin Chem 1998 44: 420-427. [Abstract] [Full Text] [PDF]  

Randall W. Yatscoff, Launa J. Aspeslet, and Heather L. Gallant

Pharmacodynamic monitoring of immunosuppressive drugs
Clin Chem 1998 44: 428-432. [Abstract] [Full Text] [PDF]  

Thomas P. Moyer and Lawrence K. Oliver

Supporting pharmaceutical studies for FDA submissions: diversifying the drug monitoring laboratory
Clin Chem 1998 44: 433-436. [Abstract] [Full Text] [PDF]  

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