Reviews:

David S. Hage

Affinity Chromatography: A Review of Clinical Applications
Clin Chem 1999 45: 593-615. [Abstract] [Full Text] [PDF]  

Opinion:

Irina V. Kaplan and Stanley S. Levinson

When Is a Heterophile Antibody Not a Heterophile Antibody? When It Is an Antibody against a Specific Immunogen
Clin Chem 1999 45: 616-618. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Stefan M. Loitsch, Stefan Kippenberger, Nurlan Dauletbaev, Thomas O.F. Wagner, and Joachim Bargon

Reverse Transcription-Competitive Multiplex PCR Improves Quantification of mRNA in Clinical Samples—Application to the Low Abundance CFTR mRNA
Clin Chem 1999 45: 619-624. [Abstract] [Full Text] [PDF]  

Renée R. Jiddou, Wan-Li Wei, Kumud S. Sane, and Anthony A. Killeen

Single-Nucleotide Polymorphisms in Intron 2 of CYP21P: Evidence for a Higher Rate of Mutation at CpG Dinucleotides in the Functional Steroid 21-Hydroxylase Gene and Application to Segregation Analysis in Congenital Adrenal Hyperplasia
Clin Chem 1999 45: 625-629. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Massimo Gion, Riccardo Mione, Antonette E. Leon, and Ruggero Dittadi

Comparison of the Diagnostic Accuracy of CA27.29 and CA15.3 in Primary Breast Cancer
Clin Chem 1999 45: 630-637. [Abstract] [Full Text] [PDF]  

Sandrine Michel, Gilbert Deléage, Jean-Philippe Charrier, Jacques Passagot, Nicole Battail-Poirot, Geneviève Sibai, Michel Jolivet, and Colette Jolivet-Reynaud

Anti-Free Prostate-specific Antigen Monoclonal Antibody Epitopes Defined by Mimotopes and Molecular Modeling
Clin Chem 1999 45: 638-650. [Abstract] [Full Text] [PDF]  

David M. Robertson, Nicholas Cahir, Henry G. Burger, Pamela Mamers, Philip I. McCloud, Kim Pettersson, and Michael McGuckin

Combined Inhibin and CA125 Assays in the Detection of Ovarian Cancer
Clin Chem 1999 45: 651-658. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Victoria F. Fredline, Eva M. Kovacs, Paul J. Taylor, and Anthony G. Johnson

Measurement of Plasma Renin Activity with Use of HPLC-Electrospray-Tandem Mass Spectrometry
Clin Chem 1999 45: 659-664. [Abstract] [Full Text] [PDF]  

Kaori Saito, Daisuke Kobayashi, Masateru Sasaki, Hiroshi Araake, Takashi Kida, Atsuhito Yagihashi, Tomomi Yajima, Hidekazu Kameshima, and Naoki Watanabe

Detection of Human Serum Tumor Necrosis Factor- in Healthy Donors, Using a Highly Sensitive Immuno-PCR Assay
Clin Chem 1999 45: 665-669. [Abstract] [Full Text] [PDF]  

Johan B. Ubbink, Rhena Delport, Reiner Riezler, and W.J. Hayward Vermaak

Comparison of Three Different Plasma Homocysteine Assays with Gas Chromatography–Mass Spectrometry
Clin Chem 1999 45: 670-675. [Abstract] [Full Text] [PDF]  

Abdul Wahed Al-Dehaimi, Aubrey Blumsohn, and Richard Eastell

Serum Galactosyl Hydroxylysine as a Biochemical Marker of Bone Resorption
Clin Chem 1999 45: 676-681. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Maria Luisa Traba, Jesús A. Calero, Cioly Méndez-Dávila, Carmen García-Moreno, and Concepción de la Piedra

Different Behaviors of Serum and Urinary CrossLaps ELISA in the Assessment of Bone Resorption in Healthy Girls
Clin Chem 1999 45: 682-683. [Full Text] [PDF]  

John W. Eastman, Fred Lorey, John Arnopp, Robert J. Currier, John Sherwin, and George Cunningham

Distribution of Hemoglobin F, A, S, C, E, and D Quantities in 4 Million Newborn Screening Specimens
Clin Chem 1999 45: 683-685. [Full Text] [PDF]  

Jordi Camps, Josep Ma Simó, Sandra Guaita, Natàlia Ferré, and Jorge Joven

Altered Composition of Lipoproteins in Liver Cirrhosis Compromises Three Homogeneous Methods for HDL-Cholesterol
Clin Chem 1999 45: 685-688. [Full Text] [PDF]  

Sandra Rieger, Herbert Riemer, and Christine Mannhalter

Multiplex PCR Assay for the Detection of Genetic Variants of ₁-Antitrypsin
Clin Chem 1999 45: 688-690. [Full Text] [PDF]  

Shaik Shavali, Michikazu Samejima, Katsuhisa Uchida, Yukitomo Morita, and Atsuo Fukuda

Improved Enzyme Immunoassay Method for Melatonin: Application to the Determination of Serum Melatonin in Rats, Sheep, and Humans
Clin Chem 1999 45: 690-692. [Full Text] [PDF]  

Estrid V.S. Høgdall, Claus K. Høgdall, Susanne K. Kjaer, Fengji Xu, Yinhua Yu, Robert C. Bast, Jan Blaakaer, and Ian J. Jacobs

OVX1 Radioimmunoassay Results Are Dependent on the Method of Sample Collection and Storage
Clin Chem 1999 45: 692-694. [Full Text] [PDF]  

Nicolas von Ahsen, Ekkehard Schütz, Victor William Armstrong, and Michael Oellerich

Rapid Detection of Prothrombotic Mutations of Prothrombin (G20210A), Factor V (G1691A), and Methylenetetrahydrofolate Reductase (C677T) by Real-Time Fluorescence PCR with the LightCycler
Clin Chem 1999 45: 694-696. [Full Text] [PDF]  

Thomas G. Cole and Nilima Parikh

High-Throughput Measurement of Oxidizability of Low-Density Lipoproteins Suitable for Use in Clinical Trials,¹
Clin Chem 1999 45: 696-699. [Full Text] [PDF]  

Richard Brandl, Reiner Probst, Burkhard Müller, Sibylle Powarzynski, Peter Carl Maurer, and Dieter Neumeier

Evaluation of the Measurement of Lysate Homocysteine in Patients with Symptomatic Arterial Disease and in Healthy Volunteers
Clin Chem 1999 45: 699-702. [Full Text] [PDF]  

History:

Louis Rosenfeld

Donald Dexter Van Slyke (1883–1971): An Oral Biography
Clin Chem 1999 45: 703-713. [Full Text] [PDF]  

Letters to the Editor:

Jerome S. Nosanchuk, Brad Combs, and Glenda Abbott

False Increases of Troponin I Attributable to Incomplete Separation of Serum • Representatives of Abbott Laboratories respond:
Clin Chem 1999 45: 714. [Full Text] [PDF]  

Daylily S. Ooi, James G. Donnelly, Stephen J. Winters, David E. Kelley, and Bret Goodpaster

More on the Analog Free-Testosterone Assay • The authors of the article cited above respond:
Clin Chem 1999 45: 714-716. [Full Text] [PDF]  

Barbara M. Roach, Joyce S. Meinke, Nagaraja Sridhar, and Adrian O. Vladutiu

Multiple Narrow Bands in Urine Protein Electrophoresis
Clin Chem 1999 45: 716-718. [Full Text] [PDF]  

David Newman and Janko Kos

More on Cystatin C • One of the authors of the article cited above responds:
Clin Chem 1999 45: 718-719. [Full Text] [PDF]  

Petrie Rainey, Idris T. Ocal, and Terrence R. Green

Digibind and Free Digoxin • The authors of the article cited above respond:
Clin Chem 1999 45: 719-721. [Full Text] [PDF]  

Book Reviews:

David D. Koch

Handbook of Interpretation of Diagnostic Tests. Jacques Wallach. Philadelphia, PA: Lippincott-Raven Publishers, 1998, 564 pp., $28.95. ISBN 0-7817-1221-1.
Clin Chem 1999 45: 722. [Full Text] [PDF]  

Geza S. Bodor

Cardiac Markers. Alan H.B. Wu, ed. Totowa, NJ: Humana Press, 1998, 300 pp., $99.50. ISBN 0-89603-434-8.
Clin Chem 1999 45: 722-723. [Full Text] [PDF]  

John Wilson

GC/MS: A Practical User's Guide. Marvin McMaster and Christopher McMaster. New York: Wiley-VCH, 1998, 167 pp., $59.95, ISBN 0-471-24826-6.
Clin Chem 1999 45: 723-724. [Full Text] [PDF]  

Clinical Chemistry Forum:

Donald S. Young

Issues in Genetic Testing
Clin Chem 1999 45: 725. [Full Text] [PDF]  

Debra G.B. Leonard

The Future of Molecular Genetic Testing
Clin Chem 1999 45: 726-731. [Abstract] [Full Text] [PDF]  

Neil A. Holtzman

Promoting Safe and Effective Genetic Tests in the United States: Work of the Task Force on Genetic Testing
Clin Chem 1999 45: 732-738. [Abstract] [Full Text] [PDF]  

Morton K. Schwartz

Genetic Testing and the Clinical Laboratory Improvement Amendments of 1988: Present and Future
Clin Chem 1999 45: 739-745. [Abstract] [Full Text] [PDF]  

Steven Gutman

The Role of Food and Drug Administration Regulation of In Vitro Diagnostic Devices—Applications to Genetics Testing
Clin Chem 1999 45: 746-749. [Abstract] [Full Text] [PDF]  

Correction:

Correction
Clin Chem 1999 45: 721. [Full Text] [PDF]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor (dbruns@aacc.org)
Clin Chem 1999 45: 750-752. [Full Text] [PDF]  

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