Editorials:

George S. Cembrowski and R. Neill Carey

Adding Value to Proficiency Testing Programs
Clin Chem 2000 46: 7-8. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

André B.P. Van Kuilenburg, Henk Van Lenthe, Annelies Tromp, Patricia C.J. Veltman, and Albert H. Van Gennip

Pitfalls in the Diagnosis of Patients with a Partial Dihydropyrimidine Dehydrogenase Deficiency
Clin Chem 2000 46: 9-17. [Abstract] [Full Text] [PDF]  

Mercè Garcia-Barceló, Lok Yee Chow, Helen Fung Kum Chiu, Yun Kowk Wing, Dominic Tak Shing Lee, Kwok Lim Lam, and Mary Miu Yee Waye

Genetic Analysis of the CYP2D6 Locus in a Hong Kong Chinese Population
Clin Chem 2000 46: 18-23. [Abstract] [Full Text] [PDF]  

Chiu-Chin Yuan, Raymond J. Peterson, Cheng-Dian Wang, Frederico Goodsaid, and David J. Waters

5' Nuclease Assays for the Loci CCR5-+/32, CCR2-V64I, and SDF1-G801A Related to Pathogenesis of AIDS
Clin Chem 2000 46: 24-30. [Abstract] [Full Text] [PDF]  

Giovanna Marrazza, Giacomo Chiti, Marco Mascini, and Mario Anichini

Detection of Human Apolipoprotein E Genotypes by DNA Electrochemical Biosensor Coupled with PCR
Clin Chem 2000 46: 31-37. [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Wayne L. Chandler, Marcy L. Jascur, and Paul J. Henderson

Measurement of Different Forms of Tissue Plasminogen Activator in Plasma
Clin Chem 2000 46: 38-46. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Klaus Jung, Brigitte Brux, Michael Lein, Birgit Rudolph, Glen Kristiansen, Steffen Hauptmann, Dietmar Schnorr, Stefan A. Loening, and Pranav Sinha

Molecular Forms of Prostate-specific Antigen in Malignant and Benign Prostatic Tissue: Biochemical and Diagnostic Implications
Clin Chem 2000 46: 47-54. [Abstract] [Full Text] [PDF]  

Klaus Jung, Ulrike Elgeti, Michael Lein, Brigitte Brux, Pranav Sinha, Birgit Rudolph, Steffen Hauptmann, Dietmar Schnorr, and Stefan A. Loening

Ratio of Free or Complexed Prostate-specific Antigen (PSA) to Total PSA: Which Ratio Improves Differentiation between Benign Prostatic Hyperplasia and Prostate Cancer?
Clin Chem 2000 46: 55-62. [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Shinichi Usui, Masakazu Nakamura, Kazuhiro Jitsukata, Masayuki Nara, Seijin Hosaki, and Mitsuyo Okazaki

Assessment of Between-Instrument Variations in a HPLC Method for Serum Lipoproteins and Its Traceability to Reference Methods for Total Cholesterol and HDL-Cholesterol
Clin Chem 2000 46: 63-72. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Rory P. Remmel, Sagar P. Kawle, Dennis Weller, and Courtney V. Fletcher

Simultaneous HPLC Assay for Quantification of Indinavir, Nelfinavir, Ritonavir, and Saquinavir in Human Plasma
Clin Chem 2000 46: 73-81. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Toshimitsu Niwa, Chika Naito, Abdul Hassan Mohammed Mawjood, and Kiyohiro Imai

Increased Glutathionyl Hemoglobin in Diabetes Mellitus and Hyperlipidemia Demonstrated by Liquid Chromatography/Electrospray Ionization-Mass Spectrometry
Clin Chem 2000 46: 82-88. [Abstract] [Full Text] [PDF]  

Laboratory Management:

Richard W. Jenny and Kathryn Y. Jackson-Tarentino

Causes of Unsatisfactory Performance in Proficiency Testing
Clin Chem 2000 46: 89-99. [Abstract] [Full Text] [PDF]  

Robert F. Martin

General Deming Regression for Estimating Systematic Bias and Its Confidence Interval in Method-Comparison Studies
Clin Chem 2000 46: 100-104. [Abstract] [Full Text] [PDF] Data Supplement  

Henriëtte Alice Hendriks, Wouter Kortlandt, and Willem Marius Verweij

Standardized Comparison of Processing Capacity and Efficiency of Five New-Generation Immunoassay Analyzers
Clin Chem 2000 46: 105-111. [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Masahiro Kimura, Ke-Ita Tatsumi, Hisato Tada, Masaki Ikemoto, Yoshihiro Fukuda, Akira Kaneko, Michio Kato, Yoh Hidaka, and Nobuyuki Amino

Enzyme Immunoassay for Autoantibodies to Human Liver-Type Arginase and Its Clinical Application
Clin Chem 2000 46: 112-117. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Doreen Osgood-McWeeney, Jennifer R. Galluzzi, and Jose M. Ordovas

Allelic Discrimination for Single Nucleotide Polymorphisms in the Human Scavenger Receptor Class B Type 1 Gene Locus Using Fluorescent Probes
Clin Chem 2000 46: 118-119. [Extract] [Full Text] [PDF]  

Tsutomu Aoshima, Yoshitaka Sekido, Takashi Miyazaki, Mitsuharu Kajita, Shunji Mimura, Kazuyoshi Watanabe, Kaoru Shimokata, and Toshimitsu Niwa

Rapid Detection of Deletion Mutations in Inherited Metabolic Diseases by Melting Curve Analysis with LightCycler
Clin Chem 2000 46: 119-122. [Extract] [Full Text] [PDF]  

Klaus Gempel, Klaus-Dieter Gerbitz, Bruno Casetta, and Matthias F. Bauer

Rapid Determination of Total Homocysteine in Blood Spots by Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry,
Clin Chem 2000 46: 122-123. [Extract] [Full Text] [PDF]  

Dan Tong, Elisabeth Kucera, Margit Stimpfl, Heinz Kölbl, Sepp Leodolter, and Robert Zeillinger

Detection of p53 Polymorphism at Codon 72 by PCR and Allele-specific Oligonucleotide Hybridization on Microtiter Plates
Clin Chem 2000 46: 124-126. [Extract] [Full Text] [PDF]  

Barbara W. Adam, J. Richard Alexander, S. Jay Smith, Donald H. Chace, J. Gerard Loeber, L. H. Elvers, and W. Harry Hannon

Recoveries of Phenylalanine from Two Sets of Dried-Blood-Spot Reference Materials: Prediction from Hematocrit, Spot Volume, and Paper Matrix
Clin Chem 2000 46: 126-128. [Extract] [Full Text] [PDF]  

Doroti Pirulli, Mara Giordano, Daniela Puzzer, Sergio Crovella, Igino Rigato, Claudio Tiribelli, Patricia Momigliano-Richiardi, and Antonio Amoroso

Rapid Method for Detection of Extra (TA) in the Promoter of the Bilirubin-UDP-Glucuronosyl Transferase 1 Gene Associated with Gilbert Syndrome
Clin Chem 2000 46: 129-131. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Nathan Gochman

Proficiency Testing of Therapeutic Drug Monitoring Techniques
Clin Chem 2000 46: 132. [Extract] [Full Text] [PDF]  

Dorine W. Swinkels, Jacques B. de Kok, Anton Hanselaar, Karel Lamers, and Rudolf H. Boerman

Early Detection of Leptomeningeal Metastasis by PCR Examination of Tumor-derived K-ras DNA in Cerebrospinal Fluid
Clin Chem 2000 46: 132-133. [Extract] [Full Text] [PDF]  

Christa M. Cobbaert and Thomas K. J. Luderer

Total Error Evaluation of Roche Direct HDL-Cholesterol Reagent and Calibrator across 31 Lot Combinations: A 2-Year Experience
Clin Chem 2000 46: 133-134. [Extract] [Full Text] [PDF]  

Noha Irani-Hakime, Hala Tamim, Ghanem Elias, Ramzi R. Finan, Jocelyn L. Daccache, and Wassim Y. Almawi

High Prevalence of Factor V Mutation (Leiden) in the Eastern Mediterranean
Clin Chem 2000 46: 134-136. [Extract] [Full Text] [PDF]  

John G. Toffaletti and Robert F. Wildermann

Use of Turbidity-Correction Algorithm Eliminates the Effect of Perflubron Emulsion on CO-Oximeter Results
Clin Chem 2000 46: 136-137. [Extract] [Full Text] [PDF]  

John G. Lewis and Peter A. Elder

Abbreviated Direct and Indirect ELISAs: A New and Simple Format
Clin Chem 2000 46: 137-139. [Extract] [Full Text] [PDF]  

Alan Mather

Excessive Phlebotomies
Clin Chem 2000 46: 139. [Extract] [Full Text] [PDF]  

Jonathan S. Krauss, Keith Bures, and Elizabeth Kenimer

Elution of Hemoglobin Montgomery₂ßS₂ Hybrid Tetramers by the Variant Apparatus
Clin Chem 2000 46: 139-140. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Garth Austin

Viral Hepatitis: Diagnosis, Therapy, and Prevention. Steven Specter, editor. Totawa, NJ: Humana Press, 1999, 402 pp., $99.50. ISBN 0-89603-424-0.
Clin Chem 2000 46: 141. [Extract] [Full Text] [PDF]  

John T. Hindmarsh

Most Commons in Pathology and Laboratory Medicine. Edward F. Goljan. Philadelphia, PA: WB Saunders Company, 1999, 516 pp., $19.95. ISBN 0-7216-7992-7.
Clin Chem 2000 46: 141. [Extract] [Full Text] [PDF]  

Gerald J. Kost

National Guideline Clearinghouse. URL: www.guideline.gov/index.asp.
Clin Chem 2000 46: 141-142. [Extract] [Full Text] [PDF]  

Garth Austin, John T. Hindmarsh, and Gerald J. Kost

National Guideline Clearinghouse. URL: www.guideline.gov/index.asp.
Clin Chem 2000 46: 141-142. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor (dbruns@aacc.org)
Clin Chem 2000 46: 143-144. [Extract] [Full Text] [PDF]  

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