Editorials:

Eleftherios P. Diamandis

Sequencing with Microarray Technology—A Powerful New Tool For Molecular Diagnostics
Clin Chem 2000 46: 1523-1525. [Extract] [Full Text] [PDF]  

Richard D. Press

Detection of Prevalent Genetic Alterations Predisposing to Hemochromatosis and Other Common Human Diseases
Clin Chem 2000 46: 1526-1528. [Extract] [Full Text] [PDF]  

Minireview:

Aldo Clerico, Silvia Del Ry, and Daniela Giannessi

Measurement of Cardiac Natriuretic Hormones (Atrial Natriuretic Peptide, Brain Natriuretic Peptide, and Related Peptides) in Clinical Practice: The Need for a New Generation of Immunoassay Methods
Clin Chem 2000 46: 1529-1534. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Ishmael Kasvosve, Joris R. Delanghe, Zvenyika A.R. Gomo, Innocent T. Gangaidzo, Hlosukwazi Khumalo, Birgitte Wuyts, Elisha Mvundura, Thokozile Saungweme, Victor M. Moyo, Johan R. Boelaert, and Victor R. Gordeuk

Transferrin Polymorphism Influences Iron Status in Blacks
Clin Chem 2000 46: 1535-1539. [Abstract] [Full Text] [PDF]  

Gerard G. Donohoe, Maija Laaksonen, Kari Pulkki, Tapani Rönnemaa, and Veli Kairisto

Rapid Single-Tube Screening of the C282Y Hemochromatosis Mutation by Real-Time Multiplex Allele-specific PCR without Fluorescent Probes
Clin Chem 2000 46: 1540-1547. [Abstract] [Full Text] [PDF]  

Jan W.P.F. Kardaun, Lon White, Helaine E. Resnick, Helen Petrovitch, Santica M. Marcovina, Ann M. Saunders, Dan J. Foley, and Richard J. Havlik

Genotypes and Phenotypes for Apolipoprotein E and Alzheimer Disease in the Honolulu-Asia Aging Study
Clin Chem 2000 46: 1548-1554. [Abstract] [Full Text] [PDF]  

Friedrik P. Wikman, Ming-Lan Lu, Thomas Thykjaer, Sanne H. Olesen, Lars D. Andersen, Carlos Cordon-Cardo, and Torben F. Ørntoft

Evaluation of the Performance of a p53 Sequencing Microarray Chip Using 140 Previously Sequenced Bladder Tumor Samples
Clin Chem 2000 46: 1555-1561. [Abstract] [Full Text] [PDF] Data Supplement  

Mats Inganäs, Sara Byding, Ann Eckersten, Solveig Eriksson, Tomas Hultman, Anneli Jorsback, Esfir Löfman, Fariba Sabounchi, Ulf Kressner, Gudrun Lindmark, and Nigel Tooke

Enzymatic Mutation Detection in the P53 Gene
Clin Chem 2000 46: 1562-1573. [Abstract] [Full Text] [PDF]  

Clara Ruiz-Ponte, Lourdes Loidi, Ana Vega, Angel Carracedo, and Francisco Barros

Rapid Real-Time Fluorescent PCR Gene Dosage Test for the Diagnosis of DNA Duplications and Deletions
Clin Chem 2000 46: 1574-1582. [Abstract] [Full Text] [PDF]  

Evidence Based Laboratory Medicine and Test Utilization:

Marcello Assumma, Fabrizio Signore, Lucia Pacifico, Naila Rossi, John F. Osborn, and Claudio Chiesa

Serum Procalcitonin Concentrations in Term Delivering Mothers and Their Healthy Offspring: A Longitudinal Study
Clin Chem 2000 46: 1583-1587. [Abstract] [Full Text] [PDF]  

Wim G. Meijer, Ido P. Kema, Marcel Volmer, Pax H.B. Willemse, and Elisabeth G.E. de Vries

Discriminating Capacity of Indole Markers in the Diagnosis of Carcinoid Tumors
Clin Chem 2000 46: 1588-1596. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Robbert J. de Winter, Johan Fischer, Radha Bholasingh, Jan P. van Straalen, Thyra de Jong, Jan G.P. Tijssen, and Gerard T. Sanders

C-Reactive Protein and Cardiac Troponin T in Risk Stratification: Differences in Optimal Timing of Tests Early after the Onset of Chest Pain
Clin Chem 2000 46: 1597-1603. [Abstract] [Full Text] [PDF]  

Fred S. Apple, F. Philip Anderson, Paul Collinson, Robert L. Jesse, Michael C. Kontos, M. Andrew Levitt, Elizabeth A. Miller, and MaryAnn M. Murakami

Clinical Evaluation of the First Medical Whole Blood, Point-of-Care Testing Device for Detection of Myocardial Infarction
Clin Chem 2000 46: 1604-1609. [Abstract] [Full Text] [PDF]  

Pauliina Nurmikko, Ville Väisänen, Timo Piironen, Sari Lindgren, Hans Lilja, and Kim Pettersson

Production and Characterization of Novel Anti-Prostate-specific Antigen (PSA) Monoclonal Antibodies That Do Not Detect Internally Cleaved Lys145-Lys146 Inactive PSA
Clin Chem 2000 46: 1610-1618. [Abstract] [Full Text] [PDF]  

Michel R. Langlois, Marie-Elise Martin, Johan R. Boelaert, Carole Beaumont, Youri E. Taes, Marc L. De Buyzere, Dirk R. Bernard, Hugo M. Neels, and Joris R. Delanghe

The Haptoglobin 2-2 Phenotype Affects Serum Markers of Iron Status in Healthy Males
Clin Chem 2000 46: 1619-1625. [Abstract] [Full Text] [PDF]  

Yeomin Yoon, Junghan Song, Seung Ho Hong, and Jin Q Kim

Plasma Nitric Oxide Concentrations and Nitric Oxide Synthase Gene Polymorphisms in Coronary Artery Disease
Clin Chem 2000 46: 1626-1630. [Abstract] [Full Text] [PDF]  

Martina Zaninotto, Franca Pagani, Sara Altinier, Paolo Amboni, Roberto Bonora, Alberto Dolci, Patrizia Pergolini, Arialdo Vernocchi, Mario Plebani, Mauro Panteghini, and for the Italian Society of Clinical Biochemistry and Clinical Molecular Biology-Italian Society of Laboratory Medicine Working Group on Markers of Myocardial Damage

Multicenter Evaluation of Five Assays for Myoglobin Determination
Clin Chem 2000 46: 1631-1637. [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Anne-Marie Lorec, Christine Juhel, Yan Pafumi, Henri Portugal, Anne-Marie Pauli, Denis Lairon, and Catherine Defoort

Determination of Apolipoprotein B-48 in Plasma by a Competitive ELISA
Clin Chem 2000 46: 1638-1642. [Abstract] [Full Text] [PDF]  

Hematology:

Ebba Nexo, Anna-Lisa Christensen, Torben E. Petersen, and Sergey N. Fedosov

Measurement of Transcobalamin by ELISA
Clin Chem 2000 46: 1643-1649. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Eduard A. Struys, Erwin E.W. Jansen, Kees de Meer, and Cornelis Jakobs

Determination of S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma and Cerebrospinal Fluid by Stable-Isotope Dilution Tandem Mass Spectrometry
Clin Chem 2000 46: 1650-1656. [Abstract] [Full Text] [PDF]  

Bruce W. Hollis

Comparison of Commercially Available ¹²⁵I-based RIA Methods for the Determination of Circulating 25-Hydroxyvitamin D
Clin Chem 2000 46: 1657-1661. [Abstract] [Full Text] [PDF]  

Lori J. Sokoll, Helen Drew, and Robert Udelsman

Intraoperative Parathyroid Hormone Analysis: A Study of 200 Consecutive Cases
Clin Chem 2000 46: 1662-1668. [Abstract] [Full Text] [PDF]  

Laboratory Management:

James M. Davenport and Brian Schlain

Testing Claimed Minimal Detectable Concentrations of in Vitro Medical Diagnostic Devices
Clin Chem 2000 46: 1669-1680. [Abstract] [Full Text] [PDF] Appendix 3  

Clinical Immunology:

Nicola Bizzaro, Elio Tonutti, Danilo Villalta, Danila Bassetti, Renato Tozzoli, Fabio Manoni, Stefano Pirrone, Anna Piazza, Paolo Rizzotti, Marco Pradella, and for The Italian Society of Laboratory Medicine Study Group on the Diagnosis of Autoimmune Diseases

Sensitivity and Specificity of Immunological Methods for the Detection of Anti-Topoisomerase I (Scl70) Autoantibodies: Results of a Multicenter Study
Clin Chem 2000 46: 1681-1685. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Yuying Tan, Li Tang, Xinghua Sun, Nan Zhang, Qinghong Han, Mingxu Xu, Eugene Baranov, Xuezhong Tan, Xiuying Tan, Babak Rashidi, Zili An, Andrew W. Perry, and Robert M. Hoffman

Total-Homocysteine Enzymatic Assay,
Clin Chem 2000 46: 1686-1688. [Extract] [Full Text] [PDF]  

Toyofumi Nakanishi, Ayako Miyazaki, Ken Iguchi, and Akira Shimizu

Effect of Hemoglobin Variants on Routine Glycohemoglobin Measurements Assessed by a Mass Spectrometric Method
Clin Chem 2000 46: 1689-1692. [Extract] [Full Text] [PDF]  

Samuel S. Chong, Corinne D. Boehm, Garry R. Cutting, and Douglas R. Higgs

Simplified Multiplex-PCR Diagnosis of Common Southeast Asian Deletional Determinants of -Thalassemia
Clin Chem 2000 46: 1692-1695. [Extract] [Full Text] [PDF]  

R. Swaminathan, Phillipa Major, Harold Snieder, and Timothy Spector

Serum Creatinine and Fat-free Mass (Lean Body Mass)
Clin Chem 2000 46: 1695-1696. [Extract] [Full Text] [PDF]  

Marek Bodzioch, Charalampos Aslanidis, Marek Kacinski, Nanbert Zhong, Krystyna E. Wisniewski, and Gerd Schmitz

Rapid Detection of the Two Most Common CLN2 Mutations Causing Classical Late Infantile Neuronal Ceroid Lipofuscinosis
Clin Chem 2000 46: 1696-1699. [Extract] [Full Text] [PDF]  

André P. Abbes, Bennie Bruggeman, Erica L.T. van den Akker, Marco R. de Groot, Anton A.M. Franken, Valentijn R. Drexhage, and Henk Engel

Identification of Two Distinct Mutations at the Same Nucleotide Position, Concomitantly with a Novel Polymorphism in the Vasopressin-Neurophysin II Gene (AVP-NP II) in Two Dutch Families with Familial Neurohypophyseal Diabetes Insipidus
Clin Chem 2000 46: 1699-1702. [Extract] [Full Text] [PDF]  

Kaori Saito, Daisuke Kobayashi, Momoko Komatsu, Tomomi Yajima, Atsuhito Yagihashi, Yukitoshi Ishikawa, Ryoji Minami, and Naoki Watanabe

A Sensitive Assay of Tumor Necrosis Factor in Sera from Duchenne Muscular Dystrophy Patients
Clin Chem 2000 46: 1703-1704. [Extract] [Full Text] [PDF]  

History:

Louis Rosenfeld

A Golden Age of Clinical Chemistry: 1948–1960
Clin Chem 2000 46: 1705-1714. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Xavier Fuentes-Arderiu, Jaume Miró-Balagué, Per Hyltoft Petersen, and Callum G. Fraser

State of the Art Instead of Biological Variation to Set Requirements for Imprecision • Following is a reply to the above letter by X. Fuentes-Arderiu and J. Miró-Balagué
Clin Chem 2000 46: 1715-1717. [Extract] [Full Text] [PDF]  

Anthony A.M. Ermens, Angelique J.M. Bayens, Adriënne Crooymans, Anita A.M. Broekman-van Hout, and Hans L.P. van Duijnhoven

Evaluation of a Simple Dot-Blot Method for the Detection of Anti-Neutrophil Cytoplasmic Antibodies Directed against Proteinase 3 and Myeloperoxidase
Clin Chem 2000 46: 1717-1719. [Extract] [Full Text] [PDF]  

Anthony W. Butch

Dilution Protocols for Detection of Hook Effects/Prozone Phenomenon
Clin Chem 2000 46: 1719-1720. [Extract] [Full Text] [PDF]  

Mary E. Tang and Jeanette C. Standage

Clin Chem 2000 46: 1720-1721. [Extract] [Full Text] [PDF]  

Correction:

Correction for vol. 45, p. 2266
Clin Chem 2000 46: 1722. [Extract] [Full Text] [PDF]  

Corrections:

Clin Chem 2000 46: 1722. [Extract] [Full Text] [PDF]  

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