Current Issues in Laboratory Medicine:

Marva M. Moxey-Mims, Marian J. Serge, Marsha N. Melvin, Robert T. McCormack, and Paula C. Southwick

Informed Consent in Clinical Trials of in Vitro Diagnostic Devices: Perspectives from the FDA and Manufacturers
Clin Chem 2001 47: 1753-1757. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Jill Rubin, Thomas A. Pearson, Roberta G. Reed, and Lars Berglund

Fluorescence-based, Nonradioactive Method for Efficient Detection of the Pentanucleotide Repeat (TTTTA)_n Polymorphism in the Apolipoprotein(a) Gene
Clin Chem 2001 47: 1758-1762. [Abstract] [Full Text] [PDF]  

Ralph Fingerhut, Wulf Röschinger, Ania C. Muntau, Torsten Dame, Jens Kreischer, Ralf Arnecke, Andrea Superti-Furga, Heinz Troxler, Bernhard Liebl, Bernhard Olgemöller, and Adelbert A. Roscher

Hepatic Carnitine Palmitoyltransferase I Deficiency: Acylcarnitine Profiles in Blood Spots Are Highly Specific
Clin Chem 2001 47: 1763-1768. [Abstract] [Full Text] [PDF]  

Evidence-based Laboratory Medicine and Test Utilization:

Raymond F. Anton, Cynthia Dominick, Michael Bigelow, and Christina Westby

Comparison of Bio-Rad %CDT TIA and CDTect as Laboratory Markers of Heavy Alcohol Use and Their Relationships with -Glutamyltransferase
Clin Chem 2001 47: 1769-1775. [Abstract] [Full Text] [PDF] Supplemental Table  

Enzymes and Protein Markers:

Magnus Sjögren, Hugo Vanderstichele, Hans Ågren, Olof Zachrisson, Mikael Edsbagge, Carsten Wikkelsø, Ingmar Skoog, Anders Wallin, Lars-Olof Wahlund, Jan Marcusson, Katarina Nägga, Niels Andreasen, Pia Davidsson, Eugeen Vanmechelen, and Kaj Blennow

Tau and Aß42 in Cerebrospinal Fluid from Healthy Adults 21–93 Years of Age: Establishment of Reference Values
Clin Chem 2001 47: 1776-1781. [Abstract] [Full Text] [PDF]  

Ursula Turpeinen, Taina Methuen, Henrik Alfthan, Kalevi Laitinen, Mikko Salaspuro, and Ulf-Håkan Stenman

Comparison of HPLC and Small Column (CDTect) Methods for Disialotransferrin
Clin Chem 2001 47: 1782-1787. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Mèonica Navarro, Simona Pichini, Magí Farré, Jordi Ortuño, Pere N. Roset, Jordi Segura, and Rafael de la Torre

Usefulness of Saliva for Measurement of 3,4-Methylenedioxymethamphetamine and Its Metabolites: Correlation with Plasma Drug Concentrations and Effect of Salivary pH
Clin Chem 2001 47: 1788-1795. [Abstract] [Full Text] [PDF]  

Juha Laakso, Martti Kulvik, Inkeri Ruokonen, Jyrki Vähätalo, Riitta Zilliacus, Markus Färkkilä, and Merja Kallio

Atomic Emission Method for Total Boron in Blood during Neutron-Capture Therapy
Clin Chem 2001 47: 1796-1803. [Abstract] [Full Text] [PDF]  

Hematology:

James A. Koziol, Ngoc J. Ho, Vincent J. Felitti, and Ernest Beutler

Reference Centiles for Serum Ferritin and Percentage of Transferrin Saturation, with Application to Mutations of the HFE Gene
Clin Chem 2001 47: 1804-1810. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Ido P. Kema, Wim G. Meijer, Gert Meiborg, Bert Ooms, Pax H.B. Willemse, and Elisabeth G.E. de Vries

Profiling of Tryptophan-related Plasma Indoles in Patients with Carcinoid Tumors by Automated, On-Line, Solid-Phase Extraction and HPLC with Fluorescence Detection
Clin Chem 2001 47: 1811-1820. [Abstract] [Full Text] [PDF]  

Jakub Krijt, Martina Vacková, and Viktor Kozich

Measurement of Homocysteine and Other Aminothiols in Plasma: Advantages of Using Tris(2-carboxyethyl)phosphine as Reductant Compared with Tri-n-butylphosphine
Clin Chem 2001 47: 1821-1828. [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Yoshiyuki Tanaka, Yuichiro Noda, Mayumi Kobayashi, Yasuko Yamada, and Konomu Hirao

Microvolume Blood-Sampling Device with Low Hemolysis and High Consistent Yield of Serum Components
Clin Chem 2001 47: 1829-1835. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Diego Gazzolo, Matteo Bruschettini, Mario Lituania, Giovanni Serra, Wanda Bonacci, and Fabrizio Michetti

Increased Urinary S100B Protein as an Early Indicator of Intraventricular Hemorrhage in Preterm Infants: Correlation with the Grade of Hemorrhage
Clin Chem 2001 47: 1836-1838. [Extract] [Full Text] [PDF]  

Annemarie Voortman, Alida Melse-Boonstra, Johanna M. Schulz, Jan Burema, Martijn B. Katan, and Petra Verhoef

Optimal Time Interval between Repeated Blood Sampling for Measurements of Total Homocysteine in Healthy Individuals
Clin Chem 2001 47: 1839-1841. [Extract] [Full Text] [PDF]  

Antonio Picarelli, Luigi Sabbatella, Marco Di Tola, Stefania Vetrano, Cristina Maffia, Cristina Picchi, Antonio Mastracchio, Paolo Paoluzi, and Maria Cristina Anania

Forty-Eight Hours of Biopsy Culture Improve the Sensitivity of the in Vitro Gliadin Challenge in the Diagnosis of Celiac Disease
Clin Chem 2001 47: 1841-1843. [Extract] [Full Text] [PDF]  

Maurie J. Luetkemeier and Jill A. Fattor

Measurement of Indocyanine Green Dye Is Improved by Use of Polyethylene Glycol to Reduce Plasma Turbidity
Clin Chem 2001 47: 1843-1845. [Extract] [Full Text] [PDF]  

Boris Rolinski, Helmut Küster, Bernhard Ugele, Rudolf Gruber, and Klaus Horn

Total Bilirubin Measurement by Photometry on a Blood Gas Analyzer: Potential for Use in Neonatal Testing at the Point of Care,
Clin Chem 2001 47: 1845-1847. [Extract] [Full Text] [PDF]  

Ryon M. Bateman, Christopher G. Ellis, Michael D. Sharpe, Sanjay Mehta, and David J. Freeman

Effect of Hemolyzed Plasma on the Batch Measurement of Nitrate by Nitric Oxide Chemiluminescence
Clin Chem 2001 47: 1847-1851. [Extract] [Full Text] [PDF]  

George Phillipov and Patrick J. Phillips

Components of Total Measurement Error for Hemoglobin A_1c Determination
Clin Chem 2001 47: 1851-1853. [Extract] [Full Text] [PDF]  

Frank Streit, Paul-Dieter Niedmann, Maria Shipkova, Victor William Armstrong, and Michael Oellerich

Rapid and Sensitive Liquid Chromatography–Tandem Mass Spectrometry Method for Determination of Monoethylglycinexylidide
Clin Chem 2001 47: 1853-1856. [Extract] [Full Text] [PDF]  

Akihiko Sekizawa, Tetsuro Kondo, Mariko Iwasaki, Akira Watanabe, Masatoshi Jimbo, Hiroshi Saito, and Takashi Okai

Accuracy of Fetal Gender Determination by Analysis of DNA in Maternal Plasma
Clin Chem 2001 47: 1856-1858. [Extract] [Full Text] [PDF]  

Nicolas von Ahsen, Bettina Ehrlich, Colin Stephen Scott, Joachim Riggert, and Michael Oellerich

Cryoglobulins Interfere with Platelet Counts by Optical and Impedance Methods but not with the CD61 Immunoplatelet Count
Clin Chem 2001 47: 1858-1860. [Extract] [Full Text] [PDF]  

András Ladányi, Richie Soong, Karim Tabiti, Béla Molnár, and Zsolt Tulassay

Quantitative Reverse Transcription-PCR Comparison of Tumor Cell Enrichment Methods
Clin Chem 2001 47: 1860-1863. [Extract] [Full Text] [PDF]  

Kayoko Minakata, Osamu Suzuki, and Fumihiko Horio

Quantification of Copper in Biological Materials by Use of Electron Spin Resonance,
Clin Chem 2001 47: 1863-1865. [Extract] [Full Text] [PDF]  

Sandy H.-J. Hsu, Wern-Cherng Cheng, Men-Wang Jang, and Keh-Sung Tsai

Effects of Long-Term Use of Raloxifene, a Selective Estrogen Receptor Modulator, on Thyroid Function Test Profiles
Clin Chem 2001 47: 1865-1867. [Extract] [Full Text] [PDF]  

Diana W. Bianchi, Erik S. LeShane, and Janet M. Cowan

Large Amounts of Cell-free Fetal DNA Are Present in Amniotic Fluid
Clin Chem 2001 47: 1867-1869. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Sashka Hristoskova, Wolfgang Holzgreve, Sinuhe Hahn, Inge J. van Wijk, and Cees B.M. Oudejans

More Than One-Half of the Erythroblasts in the Fetal Circulation and Cord Blood Are TUNEL Positive • Drs. van Wijk and Oudejans respond:
Clin Chem 2001 47: 1870-1871. [Extract] [Full Text] [PDF]  

Daniel H. Farkas

Bioelectronic DNA Chips for the Clinical Laboratory
Clin Chem 2001 47: 1871-1872. [Extract] [Full Text] [PDF]  

Hideki Mitsuhashi, Hidekazu Ikeuchi, and Yoshihisa Nojima

Is Sulfite an Antiatherogenic Compound in Wine?
Clin Chem 2001 47: 1872-1873. [Extract] [Full Text] [PDF]  

Thomas Bertsch, Wilma Zimmer, Wendy Casarin, Christof Denz, Michael Quintel, and Klaus Fassbender

Real-Time PCR Assay with Fluorescent Hybridization Probes for Rapid Interleukin-6 Promoter (-174GC) Genotyping
Clin Chem 2001 47: 1873-1874. [Extract] [Full Text] [PDF]  

Ana Vega, Clara Ruiz-Ponte, Ángel Carracedo, and Francisco Barros

Rapid Genotyping of the M129V Polymorphism of Prion Protein Using Real-Time Fluorescent PCR
Clin Chem 2001 47: 1874-1875. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Robert F. Ritchie and Thomas B. Ledue

The Immunoassay Handbook, 2nd Ed. David Wild, ed. New York, NY: Nature Publishing Group, 2001, 906 pp., hardcover, $185.00. ISBN 0-333-72306-6.
Clin Chem 2001 47: 1876. [Extract] [Full Text] [PDF]  

Correction:

Correction for vol. 46, p. 551
Clin Chem 2001 47: 1877. [Extract] [Full Text] [PDF]  

Oak Ridge Conference:

Martin J. Hessner, David M. Dinauer, Robert Kwiatkowski, Bruce Neri, and Thomas J. Raife

Age-dependent Prevalence of Vascular Disease-associated Polymorphisms among 2689 Volunteer Blood Donors
Clin Chem 2001 47: 1879-1884. [Abstract] [Full Text] [PDF]  

Paul Corstjens, Michel Zuiderwijk, Antoinette Brink, Shang Li, Hans Feindt, R. Sam Niedbala, and Hans Tanke

Use of Up-Converting Phosphor Reporters in Lateral-Flow Assays to Detect Specific Nucleic Acid Sequences: A Rapid, Sensitive DNA Test to Identify Human Papillomavirus Type 16 Infection
Clin Chem 2001 47: 1885-1893. [Abstract] [Full Text] [PDF]  

Robert Jenison, Helen La, Ayla Haeberli, Rachel Ostroff, and Barry Polisky

Silicon-based Biosensors for Rapid Detection of Protein or Nucleic Acid Targets
Clin Chem 2001 47: 1894-1900. [Abstract] [Full Text] [PDF]  

Pothur R. Srinivas, Sudhir Srivastava, Sam Hanash, and George L. Wright, Jr

Proteomics in Early Detection of Cancer
Clin Chem 2001 47: 1901-1911. [Abstract] [Full Text] [PDF]  

Joe Xi Huang, Dorothy Mehrens, Rick Wiese, Sandy Lee, Sun W. Tam, Steve Daniel, James Gilmore, Michael Shi, and Deval Lashkari

High-Throughput Genomic and Proteomic Analysis Using Microarray Technology
Clin Chem 2001 47: 1912-1916. [Abstract] [Full Text] [PDF]  

Abstracts of Oak Ridge Posters:

Martin Jones, David Alland, Salvatore Marras, Hiyam El-Hajj, Michael T. Taylor, and William McMillan

Rapid and Sensitive Detection of Mycobacterium DNA Using Cepheid SmartCycler^® and Tube Lysis System
Clin Chem 2001 47: 1917-1918. [Extract] [Full Text] [PDF]  

David S. Wishart, Lori M.M. Querengesser, Brent A. Lefebvre, Noah A. Epstein, Russ Greiner, and Jack B. Newton

Magnetic Resonance Diagnostics: A New Technology for High-Throughput Clinical Diagnostics
Clin Chem 2001 47: 1918-1921. [Extract] [Full Text] [PDF]  

Allan R. Dorn, Larry D. Mountain, Mitali Ghoshal, Raymond A. Hui, Lisa K. Klinedinst, Janice E. Rugaber, Andrew F. Schamerloh, and Salvatore J. Salamone

The Use of Inosine 5'-Monophosphate Dehydrogenase (IMPDH) in the Development of a New Liquid Homogeneous Enzyme Immunoassay Technology
Clin Chem 2001 47: 1921-1922. [Extract] [Full Text] [PDF]  

Youvraj R. Sohni, Brian Dukek, William Taylor, Elena Ricart, William J. Sandborn, and Dennis J. O’Kane

Active Electronic Arrays for Genotyping of NAT2 Polymorphisms
Clin Chem 2001 47: 1922-1924. [Extract] [Full Text] [PDF]  

John J. Hlavaty, Alan W. Partin, Felicity Kusinitz, Matthew J. Shue, Adam Stieg, Kate Bennett, and Joseph V. Briggman

Mass Spectroscopy as a Discovery Tool for Identifying Serum Markers for Prostate Cancer
Clin Chem 2001 47: 1924-1926. [Extract] [Full Text] [PDF]  

Michael C. Mullenix, Steve Wiltshire, Weiping Shao, Gary Kitos, and Barry Schweitzer

Allergen-specific IgE Detection on Microarrays Using Rolling Circle Amplification: Correlation with in Vitro Assays for Serum IgE
Clin Chem 2001 47: 1926-1929. [Extract] [Full Text] [PDF]  

Phillip Belgrader, Fariba Raisi, Rekha Joshi, Peter Nguyen, William McMillan, Jesus Ching, Ron Chang, and M. Allen Northrup

Rapid and Automated Cartridge-based Extraction of Leukocytes from Whole Blood for Microsatellite DNA Analysis by Capillary Electrophoresis
Clin Chem 2001 47: 1929-1931. [Extract] [Full Text] [PDF]  

Rinie van Beuningen, Henk van Damme, Piet Boender, Niek Bastiaensen, Alan Chan, and Tim Kievits

Fast and Specific Hybridization Using Flow-Through Microarrays on Porous Metal Oxide
Clin Chem 2001 47: 1931-1933. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2001 47: 1934. [Extract] [Full Text] [PDF]  

Accent:

ACCENT® Continuing Education Credit for Readers of Clinical Chemistry
Clin Chem 2001 47: 1935. [Extract] [Full Text] [PDF]  

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