Editorials:

Fred S. Apple and Alan H.B. Wu

Myocardial Infarction Redefined: Role of Cardiac Troponin Testing
Clin Chem 2001 47: 377-379. [Extract] [Full Text] [PDF] Erratum  

Eleftherios P. Diamandis

Signal Amplification in Time-resolved Fluorometry
Clin Chem 2001 47: 380-381. [Extract] [Full Text] [PDF]  

Special Reports:

Myocardial Infarction Redefined—A Consensus Document of The Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction
Clin Chem 2001 47: 382-392. [PDF]  

Reviews:

Ronald C. McGlennen

Miniaturization Technologies for Molecular Diagnostics
Clin Chem 2001 47: 393-402. [Abstract] [Full Text] [PDF]  

Nader Rifai and Paul M. Ridker

High-Sensitivity C-Reactive Protein: A Novel and Promising Marker of Coronary Heart Disease
Clin Chem 2001 47: 403-411. [Abstract] [Full Text] [PDF]  

Heart Health and the Clinical Laboratory:

Daylily S. Ooi, Deborah Zimmerman, Janet Graham, and George A. Wells

Cardiac Troponin T Predicts Long-Term Outcomes in Hemodialysis Patients
Clin Chem 2001 47: 412-417. [Abstract] [Full Text] [PDF]  

William L. Roberts, Linda Moulton, Terence C. Law, Genesis Farrow, Margaret Cooper-Anderson, John Savory, and Nader Rifai

Evaluation of Nine Automated High-Sensitivity C-Reactive Protein Methods: Implications for Clinical and Epidemiological Applications. Part 2
Clin Chem 2001 47: 418-425. [Abstract] [Full Text] [PDF] Erratum  

Hans K. Meier-Ewert, Paul M. Ridker, Nader Rifai, Nick Price, David F. Dinges, and Janet M. Mullington

Absence of Diurnal Variation of C-Reactive Protein Concentrations in Healthy Human Subjects
Clin Chem 2001 47: 426-430. [Abstract] [Full Text] [PDF]  

Robert H. Christenson, Show Hong Duh, Fred S. Apple, Geza S. Bodor, David M. Bunk, Joseph Dalluge, Mauro Panteghini, James D. Potter, Michael J. Welch, Alan H.B. Wu, and Stephen E. Kahn

Standardization of Cardiac Troponin I Assays: Round Robin of Ten Candidate Reference Materials
Clin Chem 2001 47: 431-437. [Abstract] [Full Text] [PDF] Data Supplements  

E. Shyong Tai, Evelyn S.C. Koay, Edmund Chan, Tzer Jing Seng, Lih Ming Loh, Sunil K. Sethi, and Chee Eng Tan

Compound Heterozygous Familial Hypercholesterolemia and Familial Defective Apolipoprotein B-100 Produce Exaggerated Hypercholesterolemia
Clin Chem 2001 47: 438-443. [Abstract] [Full Text] [PDF]  

Ira S. Ockene, Charles E. Matthews, Nader Rifai, Paul M. Ridker, George Reed, and Edward Stanek

Variability and Classification Accuracy of Serial High-Sensitivity C-Reactive Protein Measurements in Healthy Adults
Clin Chem 2001 47: 444-450. [Abstract] [Full Text] [PDF]  

Angelika Hammerer-Lercher, Petra Erlacher, Reginald Bittner, Rudolf Korinthenberg, Daniela Skladal, Stephan Sorichter, Wolfgang Sperl, Bernd Puschendorf, and Johannes Mair

Clinical and Experimental Results on Cardiac Troponin Expression in Duchenne Muscular Dystrophy
Clin Chem 2001 47: 451-458. [Abstract] [Full Text] [PDF]  

Thomas Schlüter, Hannsjörg Baum, Andreas Plewan, and Dieter Neumeier

Effects of Implantable Cardioverter Defibrillator Implantation and Shock Application on Biochemical Markers of Myocardial Damage
Clin Chem 2001 47: 459-463. [Abstract] [Full Text] [PDF]  

Robert H. Christenson, Show Hong Duh, Wendy R. Sanhai, Alan H.B. Wu, Verena Holtman, Pennell Painter, Elizabeth Branham, Fred S. Apple, MaryAnn Murakami, and Deborah L. Morris

Characteristics of an Albumin Cobalt Binding Test for Assessment of Acute Coronary Syndrome Patients: A Multicenter Study
Clin Chem 2001 47: 464-470. [Abstract] [Full Text] [PDF]  

Yoshiko Sunahara, Kohji Uchida, Toshio Tanaka, Hirokazu Matsukawa, Manabu Inagaki, and Yuhsi Matuo

Production of Recombinant Human Creatine Kinase (r-hCK) Isozymes by Tandem Repeat Expression of M and B Genes and Characterization of r-hCK-MB
Clin Chem 2001 47: 471-476. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Luisa Bonafé, Beat Thöny, Walter Leimbacher, Lucja Kierat, and Nenad Blau

Diagnosis of Dopa-responsive Dystonia and Other Tetrahydrobiopterin Disorders by the Study of Biopterin Metabolism in Fibroblasts
Clin Chem 2001 47: 477-485. [Abstract] [Full Text] [PDF]  

Karl-Anton Kreuzer, Alexander Bohn, Joachim Lupberger, Jerome Solassol, Philipp le Coutre, and Christian Andreas Schmidt

Simultaneous Absolute Quantification of Target and Control Templates by Real-Time Fluorescence Reverse Transcription-PCR Using 4-(4'-Dimethylaminophenylazo)benzoic Acid as a Dark Quencher Dye
Clin Chem 2001 47: 486-490. [Abstract] [Full Text] [PDF]  

Laura Cremonesi, Antonella Fumagalli, Nadia Soriani, Maurizio Ferrari, Sonia Levi, Silvana Belloli, Giuseppina Ruggeri, and Paolo Arosio

Double-Gradient Denaturing Gradient Gel Electrophoresis Assay for Identification of L-Ferritin Iron-responsive Element Mutations Responsible for Hereditary Hyperferritinemia-Cataract Syndrome: Identification of the New Mutation C14G
Clin Chem 2001 47: 491-497. [Abstract] [Full Text] [PDF]  

Minna Sjöroos, Jorma Ilonen, and Timo Lövgren

Solid-Phase PCR with Hybridization and Time-resolved Fluorometry for Detection of HLA-B27
Clin Chem 2001 47: 498-504. [Abstract] [Full Text] [PDF]  

Isao Miyashiro, Christine Kuo, Kelly Huynh, Aritoshi Iida, Donald Morton, Anton Bilchik, Armando Giuliano, and Dave S.B. Hoon

Molecular Strategy for Detecting Metastatic Cancers with Use of Multiple Tumor-specific MAGE-A Genes
Clin Chem 2001 47: 505-512. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Jean M. Lacey, H. Robert Bergen, Mark J. Magera, Stephen Naylor, and John F. O’Brien

Rapid Determination of Transferrin Isoforms by Immunoaffinity Liquid Chromatography and Electrospray Mass Spectrometry
Clin Chem 2001 47: 513-518. [Abstract] [Full Text] [PDF]  

Mi Hou, Dawei Xu, Magnus Björkholm, and Astrid Gruber

Real-Time Quantitative Telomeric Repeat Amplification Protocol Assay for the Detection of Telomerase Activity
Clin Chem 2001 47: 519-524. [Abstract] [Full Text] [PDF]  

Danielle S.M. Schor, Eduard A. Struys, Boris M. Hogema, K. Michael Gibson, and Cornelis Jakobs

Development of a Stable-Isotope Dilution Assay for -Aminobutyric Acid (GABA) Transaminase in Isolated Leukocytes and Evidence That GABA and ß-Alanine Transaminases Are Identical
Clin Chem 2001 47: 525-531. [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Maureen L. Sampson, Andrea Aubry, Gyorgy Csako, and Alan T. Remaley

Triple Lipid Screening Test: A Homogeneous Sequential Assay for HDL-Cholesterol, Total Cholesterol, and Triglycerides
Clin Chem 2001 47: 532-539. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Sarah Kerrigan and William H. Phillips, Jr

Comparison of ELISAs for Opiates, Methamphetamine, Cocaine Metabolite, Benzodiazepines, Phencyclidine, and Cannabinoids in Whole Blood and Urine
Clin Chem 2001 47: 540-547. [Abstract] [Full Text] [PDF]  

Elke Schaeffeler, Thomas Lang, Ulrich M. Zanger, Michel Eichelbaum, and Matthias Schwab

High-Throughput Genotyping of Thiopurine S-Methyltransferase by Denaturing HPLC
Clin Chem 2001 47: 548-555. [Abstract] [Full Text] [PDF]  

Hematology:

Jos T. Van Acker, Joris R. Delanghe, Michel R. Langlois, Youri E. Taes, Marc L. De Buyzere, and Alain G. Verstraete

Automated Flow Cytometric Analysis of Cerebrospinal Fluid
Clin Chem 2001 47: 556-560. [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Harri Härmä, Tero Soukka, and Timo Lövgren

Europium Nanoparticles and Time-resolved Fluorescence for Ultrasensitive Detection of Prostate-specific Antigen
Clin Chem 2001 47: 561-568. [Abstract] [Full Text] [PDF]  

Christina D. Karapitta, Theodore G. Sotiroudis, Athanassios Papadimitriou, and Aristotelis Xenakis

Homogeneous Enzyme Immunoassay for Triiodothyronine in Serum
Clin Chem 2001 47: 569-574. [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Rafael Venta

Year-Long Validation Study and Reference Values for Urinary Amino Acids Using a Reversed-Phase HPLC Method
Clin Chem 2001 47: 575-583. [Abstract] [Full Text] [PDF] Supplemental Tables  

Technical Briefs:

Joost C.J.M. Swaanenburg, Bert G. Loef, Marcel Volmer, Piet W. Boonstra, Jan G. Grandjean, Massimo A. Mariani, and Anne H. Epema

Creatine Kinase MB, Troponin I, and Troponin T Release Patterns after Coronary Artery Bypass Grafting with or without Cardiopulmonary Bypass and after Aortic and Mitral Valve Surgery
Clin Chem 2001 47: 584-587. [Extract] [Full Text] [PDF]  

Fred S. Apple, Maryann Murakami, Mauro Panteghini, Robert H. Christenson, Francesco Dati, Johannes Mair, and Alan H.B. Wu

International Survey on the Use of Cardiac Markers
Clin Chem 2001 47: 587-588. [Extract] [Full Text] [PDF]  

Tarekegn Geberhiwot, Alan F. Jones, William A. Bartlett, David Husband, and Steven C. Martin

Laboratory-based Calculation of Coronary Heart Disease Risk
Clin Chem 2001 47: 589-591. [Extract] [Full Text] [PDF]  

Yuriko Fischer, Karsten Filzmaier, Hugo Stiegler, Jürgen Graf, Simone Fuhs, Andreas Franke, Uwe Janssens, and Axel M. Gressner

Evaluation of a New, Rapid Bedside Test for Quantitative Determination of B-Type Natriuretic Peptide
Clin Chem 2001 47: 591-594. [Extract] [Full Text] [PDF]  

Mustafa Porsch-Özçürümez, Sabine Westphal, and Claus Luley

Measurement of Low Apolipoprotein Concentrations by Optimized Immunoturbidimetric Applications
Clin Chem 2001 47: 594-597. [Extract] [Full Text] [PDF]  

Jussi M. Halleen, Sari L. Alatalo, Anthony J. Janckila, Henning W. Woitge, Markus J. Seibel, and H. Kalervo Väänänen

Serum Tartrate-resistant Acid Phosphatase 5b Is a Specific and Sensitive Marker of Bone Resorption
Clin Chem 2001 47: 597-600. [Extract] [Full Text] [PDF]  

Christelle Dufresne, Patrick Favetta, Chantal Paradis, and Roselyne Boulieu

Comparative Study of Liquid-Liquid Extraction and Solid-Phase Extraction Methods for the Separation of Sufentanil from Plasma before Gas Chromatographic–Mass Spectrometric Analysis
Clin Chem 2001 47: 600-602. [Extract] [Full Text] [PDF]  

Rémy Sapin, Valérie Le Galudec, Françoise Gasser, Michel Pinget, and Daniel Grucker

Elecsys Insulin Assay: Free Insulin Determination and the Absence of Cross-Reactivity with Insulin Lispro,
Clin Chem 2001 47: 602-605. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Robert Siebers

How Accurate Are References in Clinical Chemistry?
Clin Chem 2001 47: 606-607. [Extract] [Full Text] [PDF]  

Bronwyn Bulmer, Greg Ward, Eleftherios Diamandis, David Nicol, and Judith Clements

Prostaglandin D Synthase Does Not Produce Prostate-specific Antigen Cross-Reactivity in Renal Cell Carcinoma
Clin Chem 2001 47: 607-608. [Extract] [Full Text] [PDF]  

Peter Cleave, Thomas D. Boswell, Dale B. Speedy, and D. Ross Boswell

Plasma Cardiac Troponin Concentrations after Extreme Exercise
Clin Chem 2001 47: 608-610. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Larry J. Kricka

Immunoassays: A Practical Approach. James P. Gosling, editor. Oxford: Oxford University Press, 2000, 304 pp., $55.00. ISBN 0-19-963710-5.
Clin Chem 2001 47: 611. [Extract] [Full Text] [PDF]  

Dates in Medicine: A Chronological Record of Medical Progress over Three Millennia. Anton Sebastian. Pearl River, NY: Parthenon Publishing Group Inc., 1999, 444 pp., $58.00. ISBN 1-85070-095-8.
Clin Chem 2001 47: 611. [Extract] [Full Text] [PDF]  

George N. Bowers, Jr

A Dictionary of the History of Medicine. Anton Sebastian. Pearl River, NY: Parthenon Publishing Group Inc., 1999, 784 pp., $98.00. ISBN 1-85070-021-4.
Clin Chem 2001 47: 611-612. [Extract] [Full Text] [PDF]  

Corrections:

Information for Authors for 2001
Clin Chem 2001 47: 612. [Extract] [Full Text] [PDF]  

Erratum:

Stepan Melnyk, Marta Pogribna, Igor P. Pogribny, Ping Yi, and S. Jill James

Measurement of Plasma and Intracellular S–Adenosylmethionine and S–Adenosylhomocysteine Utilizing Coulometric Electrochemical Detection: Alterations with Plasma Homocysteine and Pyridoxal 5'–Phosphate. Concentrations
Clin Chem 2001 47: 612. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor (dbruns@aacc.org)
Clin Chem 2001 47: 613-614. [Extract] [Full Text] [PDF]  

Accent:

ACCENT® Continuing Education Credit for Readers of Clinical Chemistry
Clin Chem 2001 47: 615-616. [Extract] [Full Text] [PDF]  

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