Introduction:

Eleftherios P. Diamandis and David E. Bruns

Cancer Diagnostics: Discovery and Clinical Applications—Introduction
Clin Chem 2002 48: 1145-1146. [Extract] [Full Text] [PDF]  

Overview:

Kenneth P.H. Pritzker

Cancer Biomarkers: Easier Said Than Done
Clin Chem 2002 48: 1147-1150. [Abstract] [Full Text] [PDF]  

Reviews:

Catharine Sturgeon

Practice Guidelines for Tumor Marker Use in the Clinic
Clin Chem 2002 48: 1151-1159. [Abstract] [Full Text] [PDF]  

Pothur R. Srinivas, Mukesh Verma, Yinming Zhao, and Sudhir Srivastava

Proteomics for Cancer Biomarker Discovery
Clin Chem 2002 48: 1160-1169. [Abstract] [Full Text] [PDF]  

Pascale F. Macgregor and Jeremy A. Squire

Application of Microarrays to the Analysis of Gene Expression in Cancer
Clin Chem 2002 48: 1170-1177. [Abstract] [Full Text] [PDF]  

Philip S. Bernard and Carl T. Wittwer

Real-Time PCR Technology for Cancer Diagnostics
Clin Chem 2002 48: 1178-1185. [Abstract] [Full Text] [PDF]  

Philip J. Johnson and Y.M. Dennis Lo

Plasma Nucleic Acids in the Diagnosis and Management of Malignant Disease
Clin Chem 2002 48: 1186-1193. [Abstract] [Full Text] [PDF]  

Michael J. Duffy

Urokinase Plasminogen Activator and Its Inhibitor, PAI-1, as Prognostic Markers in Breast Cancer: From Pilot to Level 1 Evidence Studies
Clin Chem 2002 48: 1194-1197. [Abstract] [Full Text] [PDF]  

Eleftherios P. Diamandis and George M. Yousef

Human Tissue Kallikreins: A Family of New Cancer Biomarkers
Clin Chem 2002 48: 1198-1205. [Abstract] [Full Text] [PDF]  

Ulf-Håkan Stenman

Tumor-associated Trypsin Inhibitor
Clin Chem 2002 48: 1206-1209. [Abstract] [Full Text] [PDF]  

Editorials:

Philippe Anker and Maurice Stroun

Progress in the Knowledge of Circulating Nucleic Acids: Plasma RNA Is Particle-Associated. Can It Become a General Detection Marker for a Cancer Blood Test?
Clin Chem 2002 48: 1210-1211. [Extract] [Full Text] [PDF]  

Articles:

Enders K.O. Ng, Nancy B.Y. Tsui, Nicole Y.L. Lam, Rossa W.K. Chiu, Simon C.H. Yu, S.C. Cesar Wong, Elena S.F. Lo, Timothy H. Rainer, Philip J. Johnson, and Y.M. Dennis Lo

Presence of Filterable and Nonfilterable mRNA in the Plasma of Cancer Patients and Healthy Individuals
Clin Chem 2002 48: 1212-1217. [Abstract] [Full Text] [PDF]  

Eric S. Calhoun, Renee M. McGovern, Carol A. Janney, James R. Cerhan, Stephen J. Iturria, David I. Smith, Bobbie S. Gostout, and David H. Persing

Host Genetic Polymorphism Analysis in Cervical Cancer
Clin Chem 2002 48: 1218-1224. [Abstract] [Full Text] [PDF]  

Barbara K. Zehentner, Davin C. Dillon, Yuqiu Jiang, Jiangchun Xu, Angela Bennington, David A. Molesh, XinQun Zhang, Steven G. Reed, David Persing, and Raymond L. Houghton

Application of a Multigene Reverse Transcription-PCR Assay for Detection of Mammaglobin and Complementary Transcribed Genes in Breast Cancer Lymph Nodes
Clin Chem 2002 48: 1225-1231. [Abstract] [Full Text] [PDF]  

Christina V. Obiezu, Antoninus Soosaipillai, Klaus Jung, Carsten Stephan, Andreas Scorilas, David H. C. Howarth, and Eleftherios P. Diamandis

Detection of Human Kallikrein 4 in Healthy and Cancerous Prostatic Tissues by Immunofluorometry and Immunohistochemistry
Clin Chem 2002 48: 1232-1240. [Abstract] [Full Text] [PDF]  

George M. Yousef, Andreas Scorilas, Lianna G. Kyriakopoulou, Laura Rendl, Maria Diamandis, Riccardo Ponzone, Nicoletta Biglia, Maurizia Giai, Riccardo Roagna, Piero Sismondi, and Eleftherios P. Diamandis

Human Kallikrein Gene 5 (KLK5) Expression by Quantitative PCR: An Independent Indicator of Poor Prognosis in Breast Cancer
Clin Chem 2002 48: 1241-1250. [Abstract] [Full Text] [PDF]  

Manuel Martínez, Francisco España, Montserrat Royo, José M. Alapont, Silvia Navarro, Amparo Estellés, Justo Aznar, César D. Vera, and Juan F. Jiménez-Cruz

The Proportion of Prostate-specific Antigen (PSA) Complexed to ₁-Antichymotrypsin Improves the Discrimination between Prostate Cancer and Benign Prostatic Hyperplasia in Men with a Total PSA of 10 to 30 µg/L
Clin Chem 2002 48: 1251-1256. [Abstract] [Full Text] [PDF]  

Pauliina Niemelä, Janita Lövgren, Matti Karp, Hans Lilja, and Kim Pettersson

Sensitive and Specific Enzymatic Assay for the Determination of Precursor Forms of Prostate-specific Antigen after an Activation Step
Clin Chem 2002 48: 1257-1264. [Abstract] [Full Text] [PDF]  

Alice Ylikoski, Kim Pettersson, Jussi Nurmi, Kerttu Irjala, Matti Karp, Hans Lilja, Timo Lövgren, and Martti Nurmi

Simultaneous Quantification of Prostate-specific Antigen and Human Glandular Kallikrein 2 mRNA in Blood Samples from Patients with Prostate Cancer and Benign Disease
Clin Chem 2002 48: 1265-1271. [Abstract] [Full Text] [PDF]  

Barbara R. Grzeda, Tuan Le Bui, Cheryl N. Warner, Tracy L. Pirucki, Lisa M. Dewey, Milan Babich, and Jack A. Maggiore

Measurement of Prostate-specific Antigen by Use of a Novel Blood Collection and Analytical System
Clin Chem 2002 48: 1272-1278. [Abstract] [Full Text] [PDF]  

Carsten Stephan, Henning Cammann, Axel Semjonow, Eleftherios P. Diamandis, Leon F.A. Wymenga, Michael Lein, Pranav Sinha, Stefan A. Loening, and Klaus Jung

Multicenter Evaluation of an Artificial Neural Network to Increase the Prostate Cancer Detection Rate and Reduce Unnecessary Biopsies
Clin Chem 2002 48: 1279-1287. [Abstract] [Full Text] [PDF]  

Remedios Castelló, Amparo Estellés, Carlos Vázquez, Cristina Falcó, Francisco España, Sergio M. Almenar, Carlos Fuster, and Justo Aznar

Quantitative Real-Time Reverse Transcription-PCR Assay for Urokinase Plasminogen Activator, Plasminogen Activator Inhibitor Type 1, and Tissue Metalloproteinase Inhibitor Type 1 Gene Expressions in Primary Breast Cancer
Clin Chem 2002 48: 1288-1295. [Abstract] [Full Text] [PDF]  

Jinong Li, Zhen Zhang, Jason Rosenzweig, Young Y. Wang, and Daniel W. Chan

Proteomics and Bioinformatics Approaches for Identification of Serum Biomarkers to Detect Breast Cancer
Clin Chem 2002 48: 1296-1304. [Abstract] [Full Text] [PDF]  

Mads N. Holten-Andersen, Ib Jarle Christensen, Hans Jørgen Nielsen, Hans Lilja, Gillian Murphy, Vibeke Jensen, Nils Brünner, and Timo Piironen

Measurement of the Noncomplexed Free Fraction of Tissue Inhibitor of Metalloproteinases 1 in Plasma by Immunoassay
Clin Chem 2002 48: 1305-1313. [Abstract] [Full Text] [PDF]  

Suhail M. Ali, Kim Leitzel, Vernon M. Chinchilli, Linda Engle, Laurence Demers, Harold A. Harvey, Walter Carney, Jeffrey W. Allard, and Allan Lipton

Relationship of Serum HER-2/neu and Serum CA 15-3 in Patients with Metastatic Breast Cancer
Clin Chem 2002 48: 1314-1320. [Abstract] [Full Text] [PDF]  

Haleigh Millward, Wade Samowitz, Carl T. Wittwer, and Philip S. Bernard

Homogeneous Amplification and Mutation Scanning of the p53 Gene Using Fluorescent Melting Curves
Clin Chem 2002 48: 1321-1328. [Abstract] [Full Text] [PDF]  

Siva Raja, Talal El-Hefnawy, Lori A. Kelly, Melissa L. Chestney, James D. Luketich, and Tony E. Godfrey

Temperature-controlled Primer Limit for Multiplexing of Rapid, Quantitative Reverse Transcription-PCR Assays: Application to Intraoperative Cancer Diagnostics
Clin Chem 2002 48: 1329-1337. [Abstract] [Full Text] [PDF]  

Tanya L. Applegate, Harry J. Iland, Elisa Mokany, and Alison V. Todd

Diagnosis and Molecular Monitoring of Acute Promyelocytic Leukemia Using DzyNA Reverse Transcription-PCR to Quantify PML/RAR Fusion Transcripts
Clin Chem 2002 48: 1338-1343. [Abstract] [Full Text] [PDF]  

Rong Yao, Steven A. Rich, and Erasmus Schneider

Validation of Sixteen Leukemia and Lymphoma Cell Lines as Controls for Molecular Gene Rearrangement Assays
Clin Chem 2002 48: 1344-1351. [Abstract] [Full Text] [PDF]  

Rob P.M. van Gijlswijk, Eduard G. Talman, Inge Peekel, Judith Bloem, Marcel A. van Velzen, Rob J. Heetebrij, and Hans J. Tanke

Use of Horseradish Peroxidase- and Fluorescein-modified Cisplatin Derivatives for Simultaneous Labeling of Nucleic Acids and Proteins
Clin Chem 2002 48: 1352-1359. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Thomas Schöndorf, Markus Hoopmann, Mathias Warm, Rainer Neumann, Anke Thomas, Uwe-Jochen Göhring, Carsten Eisberg, and Peter Mallmann

Serologic Concentrations of HER-2/neu in Breast Cancer Patients with Visceral Metastases Receiving Trastuzumab Therapy Predict the Clinical Course
Clin Chem 2002 48: 1360-1362. [Extract] [Full Text] [PDF]  

Neil O’Brien, Teresa M. Maguire, Norma O’Donovan, Niamh Lynch, Arnold D.K. Hill, Enda McDermott, Niall O’Higgins, and Michael J. Duffy

Mammaglobin A: A Promising Marker for Breast Cancer
Clin Chem 2002 48: 1362-1364. [Extract] [Full Text] [PDF]  

Mirka Nekulova, Ladislav Pecen, Renata Kalabova, Marta Simickova, Ondrej Topolcan, Richard Pikner, Vladimir Vondracek, and Dalibor Valik

Predicting Response of Ovarian Cancer to Paclitaxel Treatment Based on Trend Analysis of Serum CA125
Clin Chem 2002 48: 1364-1367. [Extract] [Full Text] [PDF]  

Tito Bacarese-Hamilton, Letizia Mezzasoma, Colin Ingham, Andrea Ardizzoni, Ruggero Rossi, Francesco Bistoni, and Andrea Crisanti

Detection of Allergen-specific IgE on Microarrays by Use of Signal Amplification Techniques
Clin Chem 2002 48: 1367-1370. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Lilah F. Morris, Alan D. Waxman, and Glenn D. Braunstein

Interlaboratory Comparison of Thyroglobulin Measurements for Patients with Recurrent or Metastatic Differentiated Thyroid Cancer
Clin Chem 2002 48: 1371-1372. [Extract] [Full Text] [PDF]  

Corrections:

Correction for Volume 48, Issue , p. 84
Clin Chem 2002 48: 1372. [Extract] [Full Text] [PDF]  

Accent:

ACCENT® Continuing Education Credit for Readers of Clinical Chemistry
Clin Chem 2002 48: 1373-1375. [Extract] [Full Text] [PDF]  

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