Editorials:

Mahmoud A. ElSohly

Practical Challenges to Positive Drug Tests for Marijuana
Clin Chem 2003 49: 1037-1038. [Extract] [Full Text] [PDF]  

Harvey A. Schwertner

Bilirubin Concentration, UGT1A1*28 Polymorphism, and Coronary Artery Disease
Clin Chem 2003 49: 1039-1040. [Extract] [Full Text] [PDF]  

Minireview:

Thomas M. Annesley

Ion Suppression in Mass Spectrometry
Clin Chem 2003 49: 1041-1044. [Abstract] [Full Text] [PDF]  

Baochuan Lin, Maryanne T. Vahey, Dzung Thach, David A. Stenger, and Joseph J. Pancrazio

Biological Threat Detection via Host Gene Expression Profiling
Clin Chem 2003 49: 1045-1049. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Anthony A. Killeen, John W. Breneman, III, Arlene R. Carillo, Jason Liu, and Craig S. Hixson

Linked Linear Amplification for Simultaneous Analysis of the Two Most Common Hemochromatosis Mutations
Clin Chem 2003 49: 1050-1057. [Abstract] [Full Text] [PDF]  

Kevin A. Boynton, Ian C. Summerhayes, David A. Ahlquist, and Anthony P. Shuber

DNA Integrity as a Potential Marker for Stool-based Detection of Colorectal Cancer
Clin Chem 2003 49: 1058-1065. [Abstract] [Full Text] [PDF] Supplemental Data  

Run Zhang Shi, Joseph M. Morrissey, and Janet D. Rowley

Screening and Quantification of Multiple Chromosome Translocations in Human Leukemia
Clin Chem 2003 49: 1066-1073. [Abstract] [Full Text] [PDF] Supplemental Data  

Paul N. Span, Peggy Manders, Joop J.T.M. Heuvel, Chris M.G. Thomas, Remko R. Bosch, Louk V.A.M. Beex, and C.G.J. Sweep

Molecular Beacon Reverse Transcription-PCR of Human Chorionic Gonadotropin-ß-3, -5, and -8 mRNAs Has Prognostic Value in Breast Cancer
Clin Chem 2003 49: 1074-1080. [Abstract] [Full Text] [PDF]  

Astrid Dossenbach-Glaninger, Michael van Trotsenburg, Martin Dossenbach, Christian Oberkanins, Anne Moritz, Walter Krugluger, Johannes Huber, and Pierre Hopmeier

Plasminogen Activator Inhibitor 1 4G/5G Polymorphism and Coagulation Factor XIII Val34Leu Polymorphism: Impaired Fibrinolysis and Early Pregnancy Loss
Clin Chem 2003 49: 1081-1086. [Abstract] [Full Text] [PDF]  

Genevieve Pont-Kingdon and Elaine Lyon

Rapid Detection of Aneuploidy (Trisomy 21) by Allele Quantification Combined with Melting Curves Analysis of Single-Nucleotide Polymorphism Loci
Clin Chem 2003 49: 1087-1094. [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Susann Eriksson, Miia Junikka, Päivi Laitinen, Kirsi Majamaa-Voltti, Henrik Alfthan, and Kim Pettersson

Negative Interference in Cardiac Troponin I Immunoassays from a Frequently Occurring Serum and Plasma Component
Clin Chem 2003 49: 1095-1104. [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Qiu-Ping Qin, Olli Peltola, and Kim Pettersson

Time-resolved Fluorescence Resonance Energy Transfer Assay for Point-of-Care Testing of Urinary Albumin
Clin Chem 2003 49: 1105-1113. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Richard A. Gustafson, Barry Levine, Peter R. Stout, Kevin L. Klette, M.P. George, Eric T. Moolchan, and Marilyn A. Huestis

Urinary Cannabinoid Detection Times after Controlled Oral Administration of ⁹-Tetrahydrocannabinol to Humans
Clin Chem 2003 49: 1114-1124. [Abstract] [Full Text] [PDF]  

Hematology:

Kan-Zhi Liu, Kam Sze Tsang, Chi Kong Li, R. Anthony Shaw, and Henry H. Mantsch

Infrared Spectroscopic Identification of ß-Thalassemia
Clin Chem 2003 49: 1125-1132. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Eduard A. Struys, Nanda M. Verhoeven, Birthe Roos, and Cornelis Jakobs

Disease-related Metabolites in Culture Medium of Fibroblasts from Patients with D-2-Hydroxyglutaric Aciduria, L-2-Hydroxyglutaric Aciduria, and Combined D/L-2-Hydroxyglutaric Aciduria
Clin Chem 2003 49: 1133-1138. [Abstract] [Full Text] [PDF]  

Kathleen A. O’Connor, Eleanor Brindle, Darryl J. Holman, Nancy A. Klein, Michael R. Soules, Kenneth L. Campbell, Fortüne Kohen, Coralie J. Munro, Jane B. Shofer, Bill L. Lasley, and James W. Wood

Urinary Estrone Conjugate and Pregnanediol 3-Glucuronide Enzyme Immunoassays for Population Research
Clin Chem 2003 49: 1139-1148. [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Bogumila Szponar, Leonard Krasnik, Tomasz Hryniewiecki, Andrzej Gamian, and Lennart Larsson

Distribution of 3-Hydroxy Fatty Acids in Tissues after Intraperitoneal Injection of Endotoxin
Clin Chem 2003 49: 1149-1153. [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Geoffroy Marceau, Vincent Sapin, Christine Jacomet, Sylvie Ughetto, Louis Cormerais, Christel Regagnon, Bernard Dastugue, Hélène Peigue-Lafeuille, Jean Beytout, and Henri Laurichesse

Frequency, Risk Factors, and Outcome of Hyperlactatemia in HIV-positive Persons: Implications for the Management of Treated Patients
Clin Chem 2003 49: 1154-1162. [Abstract] [Full Text] [PDF]  

Jane F. Emerson, Gilda Ngo, and Scott S. Emerson

Screening for Interference in Immunoassays
Clin Chem 2003 49: 1163-1169. [Abstract] [Full Text] [PDF]  

Pediatric Clinical Chemistry:

Lyonne K. van Rossum, Ron A.A. Mathot, Karlien Cransberg, and Arnold G. Vulto

Optimal Sampling Strategies to Assess Inulin Clearance in Children by the Inulin Single-Injection Method
Clin Chem 2003 49: 1170-1179. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Piter J. Bosma, Irene M. van der Meer, Conny T. Bakker, Albert Hofman, Marianne Paul-Abrahamse, and Jacqueline C. Witteman

UGT1A1*28 Allele and Coronary Heart Disease: The Rotterdam Study
Clin Chem 2003 49: 1180-1181. [Extract] [Full Text] [PDF]  

Mayumi Saeki, Yoshiro Saito, Hideto Jinno, Masahiro Tohkin, Kouichi Kurose, Nahoko Kaniwa, Kazuo Komamura, Kazuyuki Ueno, Shiro Kamakura, Masafumi Kitakaze, Shogo Ozawa, and Jun-ichi Sawada

Comprehensive UGT1A1 Genotyping in a Japanese Population by Pyrosequencing
Clin Chem 2003 49: 1182-1185. [Extract] [Full Text] [PDF]  

Corné H.W. Klaassen, Marcel A.F. Jeunink, Clemens F.M. Prinsen, Theo J.M. Ruers, Adriaan C.I.T.L. Tan, Luc J.A. Strobbe, and Frederik B.J.M. Thunnissen

Quantification of Human DNA in Feces as a Diagnostic Test for the Presence of Colorectal Cancer
Clin Chem 2003 49: 1185-1187. [Extract] [Full Text] [PDF]  

Tom Spiritus, Zahur Zaman, and Walter Desmet

Iodinated Contrast Media Interfere with Gel Barrier Formation in Plasma and Serum Separator Tubes
Clin Chem 2003 49: 1187-1189. [Extract] [Full Text] [PDF]  

Chung S. Ho, Brian S.S. Cheng, and Christopher W.K. Lam

Rapid Liquid Chromatography–Electrospray Tandem Mass Spectrometry Method for Serum Free and Total Carnitine
Clin Chem 2003 49: 1189-1191. [Extract] [Full Text] [PDF]  

Reinhard Ziebig, Andreas Lun, Berthold Hocher, Friedrich Priem, Claudia Altermann, Gernot Asmus, Hartmut Kern, Rolfdieter Krause, Babette Lorenz, Rainer Möbes, and Pranav Sinha

Renal Elimination of Troponin T and Troponin I
Clin Chem 2003 49: 1191-1193. [Extract] [Full Text] [PDF]  

Osamu Samura, Norio Miharu, Maki Hyodo, Hiroshi Honda, Yoko Ohashi, Nao Honda, Tetsuaki Hara, and Koso Ohama

Cell-free Fetal DNA in Maternal Circulation after Amniocentesis
Clin Chem 2003 49: 1193-1195. [Extract] [Full Text] [PDF]  

Henrik Zetterberg, Ebba Nexö, Björn Regland, Lennart Minthon, Roberta Boson, Mona Palmér, Lars Rymo, and Kaj Blennow

The Transcobalamin (TC) Codon 259 Genetic Polymorphism Influences Holo-TC Concentration in Cerebrospinal Fluid from Patients with Alzheimer Disease
Clin Chem 2003 49: 1195-1198. [Extract] [Full Text] [PDF]  

JoEtta M. Juenke, Paul I. Brown, Gwendolyn A. McMillin, and Francis M. Urry

Procedure for the Monitoring of Gabapentin with 2,4,6-Trinitrobenzene Sulfonic Acid Derivatization Followed by HPLC with Ultraviolet Detection
Clin Chem 2003 49: 1198-1201. [Extract] [Full Text] [PDF]  

Georg Endler, Ahmad Hamwi, Raute Sunder-Plassmann, Markus Exner, Thomas Vukovich, Christine Mannhalter, Johann Wojta, Kurt Huber, and Oswald Wagner

Is Low Serum Bilirubin an Independent Risk Factor for Coronary Artery Disease in Men but Not in Women?
Clin Chem 2003 49: 1201-1204. [Extract] [Full Text] [PDF]  

Svetlana Krylova, Teresa Labedz, Richard Z. Lewanczuk, and Christina G. Benishin

Generation, Characterization, and Use of Monoclonal Antibodies against Parathyroid Hypertensive Factor
Clin Chem 2003 49: 1204-1206. [Extract] [Full Text] [PDF]  

Atsuhito Yagihashi, Koichi Asanuma, Naoki Tsuji, Toshihiko Torigoe, Noriyuki Sato, Koichi Hirata, and Naoki Watanabe

Detection of Anti-Livin Antibody in Gastrointestinal Cancer Patients
Clin Chem 2003 49: 1206-1208. [Extract] [Full Text] [PDF]  

Jaume Trapé, Josep M. Botargues, Francesc Porta, Carmen Ricós, Josep M. Badal, Ramon Salinas, Maria Sala, and Angels Roca

Reference Change Value for -Fetoprotein and Its Application in Early Detection of Hepatocellular Carcinoma in Patients with Hepatic Disease
Clin Chem 2003 49: 1209-1211. [Extract] [Full Text] [PDF]  

Richard W. Troughton, Christopher M. Frampton, Timothy G. Yandle, Eric A. Espiner, Gary Nicholls, and Mark Richards

Plasma Amino-Terminal B-Type Natriuretic Peptide Measured by Elecsys 2010 Assay in a Trial of Hormone-guided Treatment for Heart Failure
Clin Chem 2003 49: 1212-1215. [Extract] [Full Text] [PDF]  

Diego Gazzolo, Maria Kornacka, Matteo Bruschettini, Mario Lituania, Lia Giovannini, Giovanni Serra, Urszula Majewska, and Fabrizio Michetti

Maternal Glucocorticoid Supplementation and S100B Protein Concentrations in Cord Blood and Urine of Preterm Infants
Clin Chem 2003 49: 1215-1218. [Extract] [Full Text] [PDF]  

Rafal Rozalski, Piotr Winkler, Daniel Gackowski, Tomasz Paciorek, Heliodor Kasprzak, and Ryszard Olinski

High Concentrations of Excised Oxidative DNA Lesions in Human Cerebrospinal Fluid
Clin Chem 2003 49: 1218-1221. [Extract] [Full Text] [PDF]  

Francesco Botrè, Claudio Botrè, Elisabetta Podestà, Mauro Podda, and Pietro Invernizzi

Effect of Anti-Carbonic Anhydrase Antibodies on Carbonic Anhydrases I and II
Clin Chem 2003 49: 1221-1223. [Extract] [Full Text] [PDF]  

Aimo Harmoinen, Terho Lehtimäki, Markku Korpela, Väinö Turjanmaa, and Heikki Saha

Diagnostic Accuracies of Plasma Creatinine, Cystatin C, and Glomerular Filtration Rate Calculated by the Cockcroft–Gault and Levey (MDRD) Formulas
Clin Chem 2003 49: 1223-1225. [Extract] [Full Text] [PDF] Supplemental Data  

Letters to the Editor:

Robert C. Hawkins and Rebecca Reeves

Hemolysis Interference in the Ortho-Clinical Diagnostics Vitros ECi cTnI Assay • Ortho-Clinical Diagnostics offers the following reply:
Clin Chem 2003 49: 1226-1227. [Extract] [Full Text] [PDF]  

Donald H. Chace, Emanuel F. Petricoin, and Lance A. Liotta

Mass Spectrometry-based Diagnostics: The Upcoming Revolution in Disease Detection Has Already Arrived • Drs. Petricoin and Liotta respond:
Clin Chem 2003 49: 1227-1229. [Extract] [Full Text] [PDF]  

Andries J. Bakker

Reliability of IFCC Method for Lactate Dehydrogenase in Heparin Plasma
Clin Chem 2003 49: 1227. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Patrick Van Roey

Introduction to Macromolecular Crystallography. Alexander McPherson. New York: Wiley-Liss, Inc., 2003, 248 pp., $69.95, softcover. ISBN 0-471-25122-4.
Clin Chem 2003 49: 1230-1231. [Extract] [Full Text] [PDF]  

Thomas P. Moyer

Leikin and Paloucek’s Poisoning and Toxicology Handbook, 3rd Edition. Jerrold Leikin and Frank Paloucek. Hudson, OH: Lexi-Comp, Inc., 2002, 1553 pp., $39.95, softcover. ISBN 1-930598-77-7.
Clin Chem 2003 49: 1230. [Extract] [Full Text] [PDF]  

Thomas G. Cole

A Manager’s Guide to the Design and Conduct of Clinical Trials. Phillip I. Good. New York: John Wiley & Sons, Inc., 2002, 242 pp., $64.95. ISBN 0-471-22615-7.
Clin Chem 2003 49: 1231-1232. [Extract] [Full Text] [PDF]  

Dan Paschal

ICP Emission Spectrometry: A Practical Guide. Joachim Nölte. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2003, 282 pp., $49.95, softcover. ISBN 3-3-527-30672-2.
Clin Chem 2003 49: 1231. [Extract] [Full Text] [PDF]  

Nelson L.S. Tang

A Clinical Guide to Inherited Metabolic Diseases, 2nd edition. Joe T.R. Clarke. Cambridge: Cambridge University Press, 2002, 306 pp., $40.00, softcover. ISBN 0-521-89076-4.
Clin Chem 2003 49: 1232-1233. [Extract] [Full Text] [PDF]  

David W. Ball

Basic Atomic and Molecular Spectroscopy. J. Michael Hollas. New York: Wiley Interscience, 2002, 192 pp., $34.95, softcover. ISBN 0-471-28162-X.
Clin Chem 2003 49: 1232. [Extract] [Full Text] [PDF]  

Terence H. Risby

Biomarkers of Disease: An Evidence-based Approach. Andrew K. Trull, Laurence M. Demers, David W. Holt, Atholl Johnston, J. Michael Tredger, and Christopher P. Price, eds. Cambridge: Cambridge University Press, 2002, 516 pp., $110.00, hardcover. ISBN 0-521-81102-3.
Clin Chem 2003 49: 1233-1234. [Extract] [Full Text] [PDF]  

Robert Rej

WebCitings
Clin Chem 2003 49: 1234. [Extract] [Full Text] [PDF]  

Corrections:

Correction
Clin Chem 2003 49: 1230. [Extract] [Full Text] [PDF]  

Obituary:

John Savory

F. William Sunderman MD, PhD (1898–2003)
Clin Chem 2003 49: 1235-1237. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2003 49: 1238-1241. [Extract] [Full Text] [PDF]  

Accent:

ACCENT® Continuing Education Credit for Readers of Clinical Chemistry
Clin Chem 2003 49: 1242-1243. [Extract] [Full Text] [PDF]  

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