Editorials:

Edward J. Thompson

Quality versus Quantity: Which Is Better for Cerebrospinal Fluid IgG?
Clin Chem 2004 50: 1721-1722. [Extract] [Full Text] [PDF]  

Peter Clements

Mass Spectrometry as a Platform for the Diagnosis of Lysosomal Disorders
Clin Chem 2004 50: 1723-1724. [Extract] [Full Text] [PDF]  

Minireview:

Amanda J. Whitfield, P. Hugh R. Barrett, Frank M. van Bockxmeer, and John R. Burnett

Lipid Disorders and Mutations in the APOB Gene
Clin Chem 2004 50: 1725-1732. Published online August 12, 2004; 10.1373/clinchem.2004.038026 [Abstract] [Full Text] [PDF]  

Opinion:

Stanley S. Levinson, James J. Miller, and Ronald J. Elin

Poor Predictive Value of High-Sensitivity C-Reactive Protein Indicates Need for Reassessment
Clin Chem 2004 50: 1733-1735. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Alla Joutovsky, Joan Hadzi-Nesic, and Michael A. Nardi

HPLC Retention Time as a Diagnostic Tool for Hemoglobin Variants and Hemoglobinopathies: A Study of 60000 Samples in a Clinical Diagnostic Laboratory
Clin Chem 2004 50: 1736-1747. [Abstract] [Full Text] [PDF] Data Supplement  

Gudrun H. Reed and Carl T. Wittwer

Sensitivity and Specificity of Single-Nucleotide Polymorphism Scanning by High-Resolution Melting Analysis
Clin Chem 2004 50: 1748-1754. Published online August 12, 2004; 10.1373/clinchem.2003.029751 [Abstract] [Full Text] [PDF] Data Supplement  

Rebecca L. Margraf, Sam Page, Maria Erali, and Carl T. Wittwer

Single-Tube Method for Nucleic Acid Extraction, Amplification, Purification, and Sequencing
Clin Chem 2004 50: 1755-1761. Published online August 12, 2004; 10.1373/clinchem.2004.035808 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Marie Lambert, Edgard E. Delvin, Gilles Paradis, Jennifer O’Loughlin, James A. Hanley, and Emile Levy

C-Reactive Protein and Features of the Metabolic Syndrome in a Population-Based Sample of Children and Adolescents
Clin Chem 2004 50: 1762-1768. Published online August 12, 2004; 10.1373/clinchem.2004.036418 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Helga Refsum, Anne W. Grindflek, Per M. Ueland, Åse Fredriksen, Klaus Meyer, Arve Ulvik, Anne B. Guttormsen, Ole E. Iversen, Jørn Schneede, and Bengt F. Kase

Screening for Serum Total Homocysteine in Newborn Children
Clin Chem 2004 50: 1769-1784. Published online August 19, 2004; 10.1373/clinchem.2004.036194 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Yijun Li, C. Ronald Scott, Nestor A. Chamoles, Ahmad Ghavami, B. Mario Pinto, Frantisek Turecek, and Michael H. Gelb

Direct Multiplex Assay of Lysosomal Enzymes in Dried Blood Spots for Newborn Screening
Clin Chem 2004 50: 1785-1796. Published online August 3, 2004; 10.1373/clinchem.2004.035907 [Abstract] [Full Text] [PDF] Data Supplement  

Dan-Li Lin, Li-Fang He, and Yao-Qun Li

Rapid and Simultaneous Determination of Coproporphyrin and Protoporphyrin in Feces by Derivative Matrix Isopotential Synchronous Fluorescence Spectrometry
Clin Chem 2004 50: 1797-1803. Published online August 12, 2004; 10.1373/clinchem.2004.034223 [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Glenn E. Palomaki, Louis M. Neveux, George J. Knight, James E. Haddow, and Raj Pandian

Maternal Serum Invasive Trophoblast Antigen (Hyperglycosylated hCG) as a Screening Marker for Down Syndrome during the Second Trimester
Clin Chem 2004 50: 1804-1808. Published online August 19, 2004; 10.1373/clinchem.2004.038059 [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Christian Fischer, Borros Arneth, Jürgen Koehler, Johannes Lotz, and Karl J. Lackner

Kappa Free Light Chains in Cerebrospinal Fluid as Markers of Intrathecal Immunoglobulin Synthesis
Clin Chem 2004 50: 1809-1813. Published online July 22, 2004; 10.1373/clinchem.2004.033977 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Raphaële Germi, Patrice Morand, Karen Brengel-Pesce, Samira Fafi-Kremer, Odile Genoulaz, Christophe Ginevra, Mirvat Ballout, Gérard Barguès, and Jean-Marie Seigneurin

Quantification of gp350/220 Epstein–Barr Virus (EBV) mRNA by Real-Time Reverse Transcription-PCR in EBV-Associated Diseases
Clin Chem 2004 50: 1814-1817. [Extract] [Full Text] [PDF] Data Supplement  

Marc G. Elgort, Mark G. Herrmann, Maria Erali, Jacob D. Durtschi, Karl V. Voelkerding, and Roger E. Smith

Extraction and Amplification of Genomic DNA from Human Blood on Nanoporous Aluminum Oxide Membranes
Clin Chem 2004 50: 1817-1819. Published online June 10, 2004; 10.1373/clinchem.2004.035162 [Extract] [Full Text] [PDF]  

Maria Erali, Jacob D. Durtschi, Karl V. Voelkerding, and Roger E. Smith

Localization and Imaging of Nucleic Acids on Nanoporous Aluminum Oxide Membranes
Clin Chem 2004 50: 1819-1821. Published online August 12, 2004; 10.1373/clinchem.2004.035170 [Extract] [Full Text] [PDF]  

Massimo Gai, Vincenzo Cantaluppi, Chiara Fenocchio, Daria Motta, Sergio Masini, Alfonso Pacitti, and Giacomo Lanfranco

Presence of Protein Fragments in Urine of Critically Ill Patients with Acute Renal Failure: A Nephrologic Enigma
Clin Chem 2004 50: 1822-1824. [Extract] [Full Text] [PDF]  

Stephan Kemp, Fredoen Valianpour, Petra A.W. Mooyer, Willem Kulik, and Ronald J.A. Wanders

Method for Measurement of Peroxisomal Very-Long-Chain Fatty Acid ß-Oxidation in Human Skin Fibroblasts Using Stable-Isotope-Labeled Tetracosanoic Acid
Clin Chem 2004 50: 1824-1826. [Extract] [Full Text] [PDF]  

Jinko Ishikawa, Terumi Taniguchi, Hitomi Higashi, Katsutoshi Miura, Kazuya Suzuki, Akihiro Takeshita, and Masato Maekawa

High Lactate Dehydrogenase Isoenzyme 1 in a Patient with Malignant Germ Cell Tumor Is Attributable to Aberrant Methylation of the LDHA Gene
Clin Chem 2004 50: 1826-1828. Published online August 5, 2004; 10.1373/clinchem.2004.037739 [Extract] [Full Text] [PDF] Data Supplement  

Jean-Pierre Basuyau, Eric Mallet, Marcelle Leroy, and Philippe Brunelle

Reference Intervals for Serum Calcitonin in Men, Women, and Children
Clin Chem 2004 50: 1828-1830. [Extract] [Full Text] [PDF]  

Riikka Vikstedt, Piia von Lode, Timo Takala, Kerttu Irjala, Olli Peltola, Kim Pettersson, and Pauli Suominen

Rapid One-Step Immunofluorometric Assay for Measuring Soluble Transferrin Receptor in Whole Blood
Clin Chem 2004 50: 1831-1833. [Extract] [Full Text] [PDF] Data Supplement  

Mustapha Maachi, Soraya Fellahi, Axel Regeniter, Marie-Emilienne Diop, Jacqueline Capeau, Jérôme Rossert, and Jean-Philippe Bastard

Patterns of Proteinuria: Urinary Sodium Dodecyl Sulfate Electrophoresis Versus Immunonephelometric Protein Marker Measurement Followed by Interpretation with the Knowledge-Based System MDI-LabLink
Clin Chem 2004 50: 1834-1837. [Extract] [Full Text] [PDF]  

Eniko Kámory, Béla Csókay, and Zsolt Holló

Rapid Detection of Cystic Fibrosis Transmembrane Conductance Regulator Gene IVS8 5T Variant by Real-Time PCR
Clin Chem 2004 50: 1837-1839. [Extract] [Full Text] [PDF]  

David G. Grenache, Kelly Hankins, Curtis A. Parvin, and Ann M. Gronowski

Cervicovaginal Interleukin-6, Tumor Necrosis Factor-, and Interleukin-2 Receptor as Markers of Preterm Delivery
Clin Chem 2004 50: 1839-1842. Published online August 12, 2004; 10.1373/clinchem.2004.034280 [Extract] [Full Text] [PDF] Data Supplement  

Lydia C.W. Lit, K.C. Allen Chan, Sing-Fai Leung, Kenny I.K. Lei, Lisa Y.S. Chan, Katherine C.K. Chow, Anthony T.C. Chan, and Y.M. Dennis Lo

Distribution of Cell-Free and Cell-Associated Epstein–Barr Virus (EBV) DNA in the Blood of Patients with Nasopharyngeal Carcinoma and EBV-Associated Lymphoma
Clin Chem 2004 50: 1842-1845. Published online August 19, 2004; 10.1373/clinchem.2004.036640 [Extract] [Full Text] [PDF] Data Supplement  

Thomas M. Annesley and Larry Clayton

Simple Extraction Protocol for Analysis of Immunosuppressant Drugs in Whole Blood
Clin Chem 2004 50: 1845-1848. Published online August 12, 2004; 10.1373/clinchem.2004.037416 [Extract] [Full Text] [PDF]  

Edmund J. Lamb, Helen J. Stowe, David E. Simpson, Anthony J. Coakley, David J. Newman, and Maeve Leahy

Diagnostic Accuracy of Cystatin C as a Marker of Kidney Disease in Patients with Multiple Myeloma: Calculated Glomerular Filtration Rate Formulas Are Equally Useful
Clin Chem 2004 50: 1848-1851. Published online August 19, 2004; 10.1373/clinchem.2004.036947 [Extract] [Full Text] [PDF] Data Supplement  

Antonio Farina, Carol W.M. Chan, Rossa W.K. Chiu, Nancy B.Y. Tsui, Paolo Carinci, Manuela Concu, Irina Banzola, Nicola Rizzo, and Y.M. Dennis Lo

Circulating Corticotropin-Releasing Hormone mRNA in Maternal Plasma: Relationship with Gestational Age and Severity of Preeclampsia
Clin Chem 2004 50: 1851-1854. [Extract] [Full Text] [PDF]  

Jacobus Petrus Johannes Ungerer, Sandra Jayne Southby, Christopher Michael Florkowski, and Peter Myles George

Automated Measurement of Cerebrospinal Fluid Bilirubin in Suspected Subarachnoid Hemorrhage
Clin Chem 2004 50: 1854-1856. Published online August 12, 2004; 10.1373/clinchem.2004.033282 [Extract] [Full Text] [PDF]  

Valentina Baldas, Tarcisio Not, Alberto Tommasini, Filippo Ansaldi, Sergio Demarini, Daniele Sblattero, Roberto Marzari, Lucio Torelli, Alberto Burlina, Claudio Tiribelli, and Alessandro Ventura

Anti-Transglutaminase Antibodies and Age
Clin Chem 2004 50: 1856-1860. [Extract] [Full Text] [PDF]  

Histories:

Nader Rifai, Gerald R. Cooper, W. Virgil Brown, William Friedewald, Richard J. Havel, Gary L. Myers, and G. Russell Warnick

Clinical Chemistry Journal Has Contributed to Progress in Lipid and Lipoprotein Testing for Fifty Years
Clin Chem 2004 50: 1861-1870. Published online August 12, 2004; 10.1373/clinchem.2004.038976 [Extract] [Full Text] [PDF]  

Carl A. Burtis, Bernard Klein, Jack Ladenson, Louis Rosenfeld, John Savory, Irving Sunshine, and Mitchell G. Scott

Fifty Years of Clinical Chemistry, Three Pioneering Editors
Clin Chem 2004 50: 1871-1877. Published online August 19, 2004; 10.1373/clinchem.2004.030411 [Extract] [Full Text] [PDF]  

Letters to the Editor:

Henrik Zetterberg and Herman Nilsson-Ehle

False-Negative Result in the Detection of an IgM Monoclonal Protein by Capillary Zone Electrophoresis
Clin Chem 2004 50: 1878-1880. Published online August 3, 2004; 10.1373/clinchem.2004.038372 [Extract] [Full Text] [PDF]  

Alessandra Barassi, Francesco Pallotti, and GianVico Melzi d’Eril

Biological Variation of Procalcitonin in Healthy Individuals
Clin Chem 2004 50: 1878. [Extract] [Full Text] [PDF]  

Koenraad Gijbels, Godelieve Mariën, and Xavier Bossuyt

Ethanol Precipitation Is Not Reliable for Selectively Removing Nonmonoclonal Peaks Seen in the Fibrinogen Region on Capillary Zone Electrophoresis of Serum Proteins
Clin Chem 2004 50: 1880-1881. [Extract] [Full Text] [PDF]  

Huub P.J. Willems, Martin den Heijer, Jan Lindemans, Henriette W.A. Berenschot, Wim B.J. Gerrits, Gerard M.J. Bos, and Henk J. Blom

Measurement of Total Homocysteine Concentrations in Acidic Citrate- and EDTA-Containing Tubes by Different Methods
Clin Chem 2004 50: 1881-1883. [Extract] [Full Text] [PDF]  

Corrections:

Correction for Volume 50, Issue , p. 1720
Clin Chem 2004 50: 1883. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Anders Kallner

Organic Chemistry Principles and Industrial Practice. Mark M. Green and Harold A. Wittcoff. Weinheim: Wiley-VCH GmbH & Co. KGaA, 2003, 342 pp., $39.00, softcover. ISBN 3-527-30289-1.
Clin Chem 2004 50: 1884. [Extract] [Full Text] [PDF]  

David Chou

Harrison’s Manual of Medicine, 15th edition. Eugene Braunwald, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, Dan L. Longo, and J. Larry Jameson. New York: McGraw-Hill, 2003, 1038 pp., $85.00, paperback with PDA software. ISBN 007-143124-1.
Clin Chem 2004 50: 1884-1885. [Extract] [Full Text] [PDF]  

Peter Wilding

Chase, Chance, and Creativity: The Lucky Art of Novelty. James H. Austin. Cambridge, MA: The MIT Press, 2003, 245 pp., $18.95, paperback. ISBN 0-262-51135-5.
Clin Chem 2004 50: 1885. [Extract] [Full Text] [PDF]  

Oak Ridge Conference:

Jessica E. Koehne, Hua Chen, Alan M. Cassell, Qi Ye, Jie Han, Meyya Meyyappan, and Jun Li

Miniaturized Multiplex Label-Free Electronic Chip for Rapid Nucleic Acid Analysis Based on Carbon Nanotube Nanoelectrode Arrays
Clin Chem 2004 50: 1886-1893. Published online August 19, 2004; 10.1373/clinchem.2004.036285 [Abstract] [Full Text] [PDF]  

Ok Kyung Cho, Yoon Ok Kim, Hiroshi Mitsumaki, and Katsuhiko Kuwa

Noninvasive Measurement of Glucose by Metabolic Heat Conformation Method
Clin Chem 2004 50: 1894-1898. Published online August 12, 2004; 10.1373/clinchem.2004.036954 [Abstract] [Full Text] [PDF]  

Jennifer Brigati, David D. Williams, Iryna B. Sorokulova, Viswaprakash Nanduri, I-Hsuan Chen, Charles L. Turnbough, Jr, and Valery A. Petrenko

Diagnostic Probes for Bacillus anthracis Spores Selected from a Landscape Phage Library
Clin Chem 2004 50: 1899-1906. Published online August 12, 2004; 10.1373/clinchem.2004.038018 [Abstract] [Full Text] [PDF]  

Petri Saviranta, Ryan Okon, Achim Brinker, Masaki Warashina, Joerg Eppinger, and Bernhard H. Geierstanger

Evaluating Sandwich Immunoassays in Microarray Format in Terms of the Ambient Analyte Regime
Clin Chem 2004 50: 1907-1920. Published online August 12, 2004; 10.1373/clinchem.2004.037929 [Abstract] [Full Text] [PDF]  

John Russell, Tracey Colpitts, Shelley Holets-McCormack, Thomas Spring, and Stephen Stroupe

Defined Protein Conjugates as Signaling Agents in Immunoassays
Clin Chem 2004 50: 1921-1929. Published online July 1, 2004; 10.1373/clinchem.2004.036681 [Abstract] [Full Text] [PDF]  

Abstracts of Oak Ridge Posters:

Peter H. Tang and Ton deGrauw

Redox Cycling of Coenzyme Q9 as a New Measure of Plasma Reducing Power
Clin Chem 2004 50: 1930-1932. [Extract] [Full Text] [PDF]  

Sharon Banin, Stuart M. Wilson, and Christopher J. Stanley

Demonstration of an Alternative Approach to Immuno-PCR
Clin Chem 2004 50: 1932-1934. [Extract] [Full Text] [PDF]  

Petri Huhtinen, Anne-Maria Pelkkikangas, Sinikka Jaakohuhta, Timo Lövgren, and Harri Härmä

Quantitative, Rapid Europium(III) Nanoparticle-Label-Based All-in-One Dry-Reagent Immunoassay for Thyroid-Stimulating Hormone
Clin Chem 2004 50: 1935-1936. [Extract] [Full Text] [PDF]  

Farhana Afroz, Anthony D. Barone, Paul A. Bury, Chuan Chen, Andrea Cuppoletti, Robert G. Kuimelis, Handong Li, and Glenn H. McGall

Photo-Removable Protecting Groups for in Situ DNA Microarray Synthesis
Clin Chem 2004 50: 1936-1939. [Extract] [Full Text] [PDF]  

Zheng Wang, Christine Yip, Yong Ying, Jing Wang, Xiao-Ying Meng, Lee Lomas, Tai-Tung Yip, and Eric T. Fung

Mass Spectrometric Analysis of Protein Markers for Ovarian Cancer
Clin Chem 2004 50: 1939-1942. [Extract] [Full Text] [PDF]  

Bruce Campbell, Jason Lei, David Kiaei, Dennis Sustarsic, and Saïd El Shami

Nucleic Acid Testing Using Surface Plasmon Resonance Fluorescence Detection
Clin Chem 2004 50: 1942-1943. [Extract] [Full Text] [PDF]  

Alice Ylikoski, Annika Elomaa, Pia Ollikka, Harri Hakala, Veli-Matti Mukkala, Jari Hovinen, and Ilkka Hemmilä

Homogeneous Time-Resolved Fluorescence Quenching Assay (TruPoint) for Nucleic Acid Detection
Clin Chem 2004 50: 1943-1947. [Extract] [Full Text] [PDF] Data Supplement  

Steven C. Kazmierczak, Vladimir Ostoich, Ken Aron, Audie Hickey, Diana E. Kazmierczak, and Dennis M. Bleile

Clinical Evaluation of an Algorithm for Short Sample Detection on a Multi-analyte Panel Using a Point-of-Care Analyzer
Clin Chem 2004 50: 1947-1949. [Extract] [Full Text] [PDF]  

Ramesh Ramakrishnan, Wesley Buckingham, Marc Domanus, Linn Gieser, Karin Klein, Gregory Kunkel, Anna Prokhorova, and Peter V. Riccelli

Sensitive Assay for Identification of Methicillin-Resistant Staphylococcus aureus, Based on Direct Detection of Genomic DNA by Use of Gold Nanoparticle Probes
Clin Chem 2004 50: 1949-1952. Published online August 19, 2004; 10.1373/clinchem.2004.036723 [Extract] [Full Text] [PDF]  

Amin A. Mohammad, Elizabeth C. Elefano, Darin Leigh, Daniel Stredler, Anthony O. Okorodudu, and John R. Petersen

Use of Computer Simulation to Study Impact of Increasing Routine Test Volume on Turnaround Times of STAT Samples on ci8200 Integrated Chemistry and Immunoassay Analyzer
Clin Chem 2004 50: 1952-1955. [Extract] [Full Text] [PDF]  

Peng Hou, Meiju Ji, Song Li, and Zuhong Lu

Microarray-Based Approach for High-Throughput Genotyping of Single-Nucleotide Polymorphisms with Layer-by-Layer Dual-Color Fluorescence Hybridization
Clin Chem 2004 50: 1955-1957. [Extract] [Full Text] [PDF]  

Thomas M. Houts

Useful Estimates of Assay Performance from Small Data Sets
Clin Chem 2004 50: 1958-1959. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2004 50: 1960. [Extract] [Full Text] [PDF]  

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