Clinical Chemistry -- Table of Contents (November 1 2004, 50 [11])

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Editorials:

Rafael de la Torre and Simona Pichini: Usefulness of Sweat Testing for the Detection of Cannabis Smoke
Clin Chem 2004 50: 1961-1962. [Extract] [Full Text] [PDF]

Luis A. Ugozzoli: Multiplex Assays with Fluorescent Microbead Readout: A Powerful Tool for Mutation Detection
Clin Chem 2004 50: 1963-1965. [Extract] [Full Text] [PDF]

Véronique Préat: Noninvasive Lithium Monitoring
Clin Chem 2004 50: 1966-1967. [Extract] [Full Text] [PDF]

Martin H. Kroll: Evaluating Interference Caused by Lipemia
Clin Chem 2004 50: 1968-1969. [Extract] [Full Text] [PDF]

Cindy R. WalkerPeach and Brittan L. Pasloske: DNA Bacteriophage as Controls for Clinical Viral Testing
Clin Chem 2004 50: 1970-1971. [Extract] [Full Text] [PDF]

Joris R. Delanghe and Marc L. De Buyzere: Development of an ELISA for the Determination of the Major Haptoglobin Phenotype: An Interesting Technical Development and Its Potential Consequences
Clin Chem 2004 50: 1972-1973. [Extract] [Full Text] [PDF]

Opinion:

Dimitri Tchernitchko, Michel Goossens, and Henri Wajcman: In Silico Prediction of the Deleterious Effect of a Mutation: Proceed with Caution in Clinical Genetics
Clin Chem 2004 50: 1974-1978. [Abstract] [Full Text] [PDF]

Molecular Diagnostics and Genetics:

Maria Fuller, Melanie Lovejoy, Doug A. Brooks, Miriam L. Harkin, John J. Hopwood, and Peter J. Meikle: Immunoquantification of ${alpha}$ -Galactosidase: Evaluation for the Diagnosis of Fabry Disease
Clin Chem 2004 50: 1979-1985. Published online September 13, 2004; 10.1373/clinchem.2004.037937 [Abstract] [Full Text] [PDF]

Paul N. Span, Fred C.G.J. Sweep, Erwin T.G. Wiegerinck, Vivianne C.G. Tjan-Heijnen, Peggy Manders, Louk V.A.M. Beex, and Jaques B. de Kok: Survivin Is an Independent Prognostic Marker for Risk Stratification of Breast Cancer Patients
Clin Chem 2004 50: 1986-1993. Published online September 13, 2004; 10.1373/clinchem.2004.039149 [Abstract] [Full Text] [PDF]

Catherine I. Dumur, Suhail Nasim, Al M. Best, Kellie J. Archer, Amy C. Ladd, Valeria R. Mas, David S. Wilkinson, Carleton T. Garrett, and Andrea Ferreira-Gonzalez: Evaluation of Quality-Control Criteria for Microarray Gene Expression Analysis
Clin Chem 2004 50: 1994-2002. Published online September 13, 2004; 10.1373/clinchem.2004.033225 [Abstract] [Full Text] [PDF] Supplemental Data

Francisco Sanz-Rodriguez, Africa Fernandez-L., Roberto Zarrabeitia, Alfonso Perez-Molino, Jose R. Ramírez, Eliecer Coto, Carmelo Bernabeu, and Luisa M. Botella: Mutation Analysis in Spanish Patients with Hereditary Hemorrhagic Telangiectasia: Deficient Endoglin Up-regulation in Activated Monocytes
Clin Chem 2004 50: 2003-2011. Published online September 16, 2004; 10.1373/clinchem.2004.035287 [Abstract] [Full Text] [PDF] Supplemental Data

Giuliana Fortunato, Elio Marciano, Federica Zarrilli, Cristina Mazzaccara, Mariano Intrieri, Giuseppe Calcagno, Dino F. Vitale, Paolo La Manna, Claudio Saulino, Vincenzo Marcelli, and Lucia Sacchetti: Paraoxonase and Superoxide Dismutase Gene Polymorphisms and Noise-Induced Hearing Loss
Clin Chem 2004 50: 2012-2018. Published online September 2, 2004; 10.1373/clinchem.2004.037788 [Abstract] [Full Text] [PDF]

Scott C. Johnson, David J. Marshall, Gerda Harms, Christie M. Miller, Christopher B. Sherrill, Edward L. Beaty, Scott A. Lederer, Eric B. Roesch, Gary Madsen, Gary L. Hoffman, Ronald H. Laessig, Greg J. Kopish, Mei Wang Baker, Steven A. Benner, Philip M. Farrell, and James R. Prudent: Multiplexed Genetic Analysis Using an Expanded Genetic Alphabet
Clin Chem 2004 50: 2019-2027. Published online August 19, 2004; 10.1373/clinchem.2004.034330 [Abstract] [Full Text] [PDF] Data Supplement

Susan Bortolin, Margot Black, Hemanshu Modi, Ihor Boszko, Daniel Kobler, Dan Fieldhouse, Eve Lopes, Jean-Michel Lacroix, Rebecca Grimwood, Philip Wells, Richard Janeczko, and Roman Zastawny: Analytical Validation of the Tag-It High-Throughput Microsphere-Based Universal Array Genotyping Platform: Application to the Multiplex Detection of a Panel of Thrombophilia-Associated Single-Nucleotide Polymorphisms
Clin Chem 2004 50: 2028-2036. Published online September 13, 2004; 10.1373/clinchem.2004.035071 [Abstract] [Full Text] [PDF]

Nicole J. Morin, Zhilong Gong, and Xing-Fang Li: Reverse Transcription-Multiplex PCR Assay for Simultaneous Detection of Escherichia coli O157:H7, Vibrio cholerae O1, and Salmonella Typhi
Clin Chem 2004 50: 2037-2044. Published online September 13, 2004; 10.1373/clinchem.2004.036814 [Abstract] [Full Text] [PDF]

Michiyo Urata, Yui Wada, Sang Ho Kim, Worawan Chumpia, Yuzo Kayamori, Naotaka Hamasaki, and Dongchon Kang: High-Sensitivity Detection of the A3243G Mutation of Mitochondrial DNA by a Combination of Allele-Specific PCR and Peptide Nucleic Acid-Directed PCR Clamping
Clin Chem 2004 50: 2045-2051. Published online September 13, 2004; 10.1373/clinchem.2004.033761 [Abstract] [Full Text] [PDF] Supplemental Data

Evidence-based Laboratory Medicine and Test Utilization:

Sanne Bruins, M. Rebecca Fokkema, Jeroen W.P. Römer, Mike J.L. DeJongste, Fey P.L. van der Dijs, Jody M.W. van den Ouweland, and Frits A.J. Muskiet: High Intraindividual Variation of B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP in Patients with Stable Chronic Heart Failure
Clin Chem 2004 50: 2052-2058. Published online September 2, 2004; 10.1373/clinchem.2004.038752 [Abstract] [Full Text] [PDF]

Proteomics and Protein Markers:

Timo Piironen, Birgitte Laursen, Jesper Pass, Karin List, Henrik Gårdsvoll, Michael Ploug, Keld Danø, and Gunilla Høyer-Hansen: Specific Immunoassays for Detection of Intact and Cleaved Forms of the Urokinase Receptor
Clin Chem 2004 50: 2059-2068. Published online September 2, 2004; 10.1373/clinchem.2004.038232 [Abstract] [Full Text] [PDF]

Cancer Diagnostics:

Barbara K. Zehentner, David H. Persing, Amadou Deme, Papa Toure, Stephen E. Hawes, Lisa Brooks, Qinghua Feng, Dawn C. Hayes, Cathy W. Critichlow, Raymond L. Houghton, and Nancy B. Kiviat: Mammaglobin as a Novel Breast Cancer Biomarker: Multigene Reverse Transcription-PCR Assay and Sandwich ELISA
Clin Chem 2004 50: 2069-2076. Published online September 16, 2004; 10.1373/clinchem.2004.038687 [Abstract] [Full Text] [PDF]

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Salvatore Campo, Maria A. Sardo, Alessandra Bitto, Antonio Bonaiuto, Giuseppe Trimarchi, Michele Bonaiuto, Maria Castaldo, Carlo Saitta, Simona Cristadoro, and Antonino Saitta: Platelet-Activating Factor Acetylhydrolase Is Not Associated with Carotid Intima-Media Thickness in Hypercholesterolemic Sicilian Individuals
Clin Chem 2004 50: 2077-2082. Published online September 13, 2004; 10.1373/clinchem.2004.036863 [Abstract] [Full Text] [PDF]

Drug Monitoring and Toxicology:

Takeshi Saito, Abraham Wtsadik, Karl B. Scheidweiler, Neil Fortner, Sanae Takeichi, and Marilyn A. Huestis: Validated Gas Chromatographic–Negative Ion Chemical Ionization Mass Spectrometric Method for ${Delta}$ ⁹-Tetrahydrocannabinol in Sweat Patches
Clin Chem 2004 50: 2083-2090. Published online July 22, 2004; 10.1373/clinchem.2004.034868 [Abstract] [Full Text] [PDF]

Benoît Leboulanger, Jean-Michel Aubry, Guido Bondolfi, Richard H. Guy, and M. Begoña Delgado-Charro: Lithium Monitoring by Reverse Iontophoresis in Vivo
Clin Chem 2004 50: 2091-2100. Published online June 10, 2004; 10.1373/clinchem.2004.034249 [Abstract] [Full Text] [PDF]

Endocrinology and Metabolism:

Katleen Van Uytfanghe, Dietmar Stöckl, Jean M. Kaufman, Tom Fiers, H. Alec Ross, André P. De Leenheer, and Linda M. Thienpont: Evaluation of a Candidate Reference Measurement Procedure for Serum Free Testosterone Based on Ultrafiltration and Isotope Dilution–Gas Chromatography–Mass Spectrometry
Clin Chem 2004 50: 2101-2110. Published online September 16, 2004; 10.1373/clinchem.2004.037358 [Abstract] [Full Text] [PDF]

René A. de Bruin, Angelique Bouhuizen, Sven Diederich, Frank H. Perschel, Frans Boomsma, and Jaap Deinum: Validation of a New Automated Renin Assay
Clin Chem 2004 50: 2111-2116. [Abstract] [Full Text] [PDF]

General Clinical Chemistry:

André B.P. van Kuilenburg, Henk van Lenthe, Monika Löffler, and Albert H. van Gennip: Analysis of Pyrimidine Synthesis "de Novo" Intermediates in Urine and Dried Urine Filter- Paper Strips with HPLC–Electrospray Tandem Mass Spectrometry
Clin Chem 2004 50: 2117-2124. Published online September 16, 2004; 10.1373/clinchem.2004.038869 [Abstract] [Full Text] [PDF]

Clinical Immunology:

Britta Van Meensel, Martin Hiele, Ilse Hoffman, Severine Vermeire, Paul Rutgeerts, Karel Geboes, and Xavier Bossuyt: Diagnostic Accuracy of Ten Second-Generation (Human) Tissue Transglutaminase Antibody Assays in Celiac Disease
Clin Chem 2004 50: 2125-2135. Published online September 23, 2004; 10.1373/clinchem.2004.035832 [Abstract] [Full Text] [PDF]

Marie Bennermo, Claes Held, Sten Stemme, Carl-Göran Ericsson, Angela Silveira, Fiona Green, and Per Tornvall: Genetic Predisposition of the Interleukin-6 Response to Inflammation: Implications for a Variety of Major Diseases?
Clin Chem 2004 50: 2136-2140. Published online September 13, 2004; 10.1373/clinchem.2004.037531 [Abstract] [Full Text] [PDF]

Mogens Fenger, Allan Wiik, Mimi Høier-Madsen, Jens J. Lykkegaard, Teresa Rozenfeld, Michael S. Hansen, Bente Danneskjold Samsoe, and Søren Jacobsen: Detection of Antinuclear Antibodies by Solid-Phase Immunoassays and Immunofluorescence Analysis
Clin Chem 2004 50: 2141-2147. Published online September 2, 2004; 10.1373/clinchem.2004.038422 [Abstract] [Full Text] [PDF] Supplemental Data

Technical Briefs:

Nina S. Levy and Andrew P. Levy: ELISA for Determination of the Haptoglobin Phenotype
Clin Chem 2004 50: 2148-2150. [Extract] [Full Text] [PDF]

Giuseppe Lippi and Gian Cesare Guidi: Effect of Specimen Collection on Routine Coagulation Assays and D-Dimer Measurement
Clin Chem 2004 50: 2150-2152. [Extract] [Full Text] [PDF]

Karim Hamaoui, Asif Butt, Jake Powrie, and R. Swaminathan: Concentration of Circulating Rhodopsin mRNA in Diabetic Retinopathy
Clin Chem 2004 50: 2152-2155. [Extract] [Full Text] [PDF]

M. Esther Farez-Vidal, Carolina Gómez-Llorente, Sonia Blanco, Pablo Morales, Teresa Casals, and Jose Antonio Gómez-Capilla: Multimutational Analysis of Eleven Cystic Fibrosis Mutations Common in the Mediterranean Areas
Clin Chem 2004 50: 2155-2157. [Extract] [Full Text] [PDF] Supplemental Data

Mark D. Kellogg, Jasna Behaderovic, Oneil Bhalala, and Nader Rifai: Rapid and Simple Tandem Mass Spectrometry Method for Determination of Serum Cotinine Concentration
Clin Chem 2004 50: 2157-2159. [Extract] [Full Text] [PDF] Supplemental Data

Deirdré Hartman, Giuseppe A. Sagnella, Christine A. Chesters, and Graham A. MacGregor: Direct Renin Assay and Plasma Renin Activity Assay Compared
Clin Chem 2004 50: 2159-2161. Published online August 31, 2004; 10.1373/clinchem.2004.033654 [Extract] [Full Text] [PDF]

Pierre N.M. Demacker, Emine Bolat, Helga I. Toenhake-Dijkstra, and Lambertus J.H. van Tits: Factors Influencing Isoprotein Dependency of Polyclonal Apolipoprotein(a) Assays
Clin Chem 2004 50: 2161-2163. [Extract] [Full Text] [PDF] Supplemental Data

Markus Stöcher and Jörg Berg: Internal Control DNA for PCR Assays Introduced into Lambda Phage Particles Exhibits Nuclease Resistance
Clin Chem 2004 50: 2163-2166. Published online August 19, 2004; 10.1373/clinchem.2004.035519 [Extract] [Full Text] [PDF] Data Supplement

Benjamin Maneglier, Christine Rogez-Kreuz, Paulette Cordonnier, Patrice Therond, Charles Advenier, Dominique Dormont, Pascal Clayette, and Odile Spreux-Varoquaux: Simultaneous Measurement of Kynurenine and Tryptophan in Human Plasma and Supernatants of Cultured Human Cells by HPLC with Coulometric Detection
Clin Chem 2004 50: 2166-2168. [Extract] [Full Text] [PDF]

Jan-Christian Wasmuth, Barbara Grün, Birgit Terjung, Angela Homrighausen, and Ulrich Spengler: ROC Analysis Comparison of Three Assays for the Detection of Antibodies against Double-Stranded DNA in Serum for the Diagnosis of Systemic Lupus Erythematosus
Clin Chem 2004 50: 2169-2171. [Extract] [Full Text] [PDF] Supplemental Data

Hannes M. Müller, Simone Millinger, Heidi Fiegl, Georg Goebel, Lennart Ivarsson, Andreas Widschwendter, Elisabeth Müller-Holzner, Christian Marth, and Martin Widschwendter: Analysis of Methylated Genes in Peritoneal Fluids of Ovarian Cancer Patients: A New Prognostic Tool
Clin Chem 2004 50: 2171-2173. [Extract] [Full Text] [PDF] Supplemental Data

Patricia M. Crofton, Nancy Evans, Mervyn R.H. Taylor, and Celia V. Holland: Procollagen Type I Amino-Terminal Propeptide: Pediatric Reference Data and Relationship with Procollagen Type I Carboxyl-Terminal Propeptide
Clin Chem 2004 50: 2173-2176. [Extract] [Full Text] [PDF]

Junghan Song, Kyoung Un Park, Hyung Doo Park, Yeomin Yoon, and Jin Q. Kim: High-Throughput Liquid Chromatography–Tandem Mass Spectrometry Assay for Plasma Theophylline and Its Metabolites
Clin Chem 2004 50: 2176-2179. [Extract] [Full Text] [PDF] Supplemental Data

Wai K. Leung, Ka-Fai To, Ellen P.S. Man, Michael W.Y. Chan, Alfa H.C. Bai, Aric J. Hui, Francis K.L. Chan, Janet F.Y. Lee, and Joseph J. Y. Sung: Detection of Epigenetic Changes in Fecal DNA as a Molecular Screening Test for Colorectal Cancer: A Feasibility Study
Clin Chem 2004 50: 2179-2182. [Extract] [Full Text] [PDF]

Tanja Heller, Michael Oellerich, Victor William Armstrong, and Nicolas von Ahsen: Rapid Detection of ITPA 94C>A and IVS2 + 21A>C Gene Mutations by Real-Time Fluorescence PCR and in Vitro Demonstration of Effect of ITPA IVS2 + 21A>C Polymorphism on Splicing Efficiency
Clin Chem 2004 50: 2182-2184. [Extract] [Full Text] [PDF]

Thomas C. Register, Kathryn P. Burdon, Leon Lenchik, Donald W. Bowden, Gregory A. Hawkins, Barbara J. Nicklas, Kurt Lohman, Fang-Chi Hsu, Carl D. Langefeld, and John J. Carr: Variability of Serum Soluble Intercellular Adhesion Molecule-1 Measurements Attributable to a Common Polymorphism
Clin Chem 2004 50: 2185-2187. [Extract] [Full Text] [PDF]

Anurag Kumar Gupta, Wolfgang Holzgreve, Berthold Huppertz, Antoine Malek, Henning Schneider, and Sinuhe Hahn: Detection of Fetal DNA and RNA in Placenta-Derived Syncytiotrophoblast Microparticles Generated in Vitro
Clin Chem 2004 50: 2187-2190. [Extract] [Full Text] [PDF]

Didier Borderie, Yannick Allanore, Christophe Meune, Jean Y. Devaux, Ohvanesse G. Ekindjian, and André Kahan: High Ischemia-Modified Albumin Concentration Reflects Oxidative Stress But Not Myocardial Involvement in Systemic Sclerosis
Clin Chem 2004 50: 2190-2193. [Extract] [Full Text] [PDF]

Sun-Young Kong, Chang-Seok Ki, Hee-Jin Kim, Ki-o Lee, Jae-chun Bae, Sun-Hee Kim, and Jong-Won Kim: Evaluation of Imprecision for Analysis of Short Tandem Repeats by Use of Mixed Blood Cells in Variable Concentrations
Clin Chem 2004 50: 2193-2195. [Extract] [Full Text] [PDF]

Graham D. Carter, Richard Carter, Julia Jones, and Jacqueline Berry: How Accurate Are Assays for 25-Hydroxyvitamin D? Data from the International Vitamin D External Quality Assessment Scheme
Clin Chem 2004 50: 2195-2197. Published online September 16, 2004; 10.1373/clinchem.2004.040683 [Extract] [Full Text] [PDF]

Joshua A. Bornhorst, Richard F. Roberts, and William L. Roberts: Assay-Specific Differences in Lipemic Interference in Native and Intralipid-Supplemented Samples
Clin Chem 2004 50: 2197-2201. Published online September 16, 2004; 10.1373/clinchem.2004.040154 [Extract] [Full Text] [PDF]

María Collado, Olfert Landt, Eva Barragán, Ulrich Lass, José Cervera, Miguel A. Sanz, and Pascual Bolufer: Locked Nucleic Acid-Enhanced Detection of 1100delC*CHEK2 Germ-Line Mutation in Spanish Patients with Hematologic Malignancies
Clin Chem 2004 50: 2201-2204. [Extract] [Full Text] [PDF]

History:

Sidney B. Rosalki, Robert Roberts, Hugo A. Katus, Evangelos Giannitsis, Jack H. Ladenson, and Fred S. Apple: Cardiac Biomarkers for Detection of Myocardial Infarction: Perspectives from Past to Present
Clin Chem 2004 50: 2205-2213. [Abstract] [Full Text] [PDF]

Letters to the Editor:

Juergen R. Schaefer, Alexander M. Sattler, Bastian Hackler, Bilgen Kurt, Rolf Hackler, Bernhard Maisch, and Muhidien Soufi: Hyperlipidemia in Patients with Apolipoprotein E 2/2 Phenotype: Apolipoprotein A5 S19W Mutation as a Cofactor
Clin Chem 2004 50: 2214. [Extract] [Full Text] [PDF]

Najib Aziz, Michael R. Irwin, Sally S. Dickerson, and Anthony W. Butch: Spurious Tumor Necrosis Factor- ${alpha}$ and Interleukin-6 Production by Human Monocytes from Blood Collected in Endotoxin-Contaminated Vacutainer Blood Collection Tubes
Clin Chem 2004 50: 2215-2216. [Extract] [Full Text] [PDF]

Dietmar Stöckl, Diego Rodríguez Cabaleiro, Katleen Van Uytfanghe, and Linda M. Thienpont: Interpreting Method Comparison Studies by Use of the Bland–Altman Plot: Reflecting the Importance of Sample Size by Incorporating Confidence Limits and Predefined Error Limits in the Graphic
Clin Chem 2004 50: 2216-2218. [Extract] [Full Text] [PDF]

Kunihiro Iwahara, Chizuko Tanabe, and Masato Maekawa: No Interference by Diclofenac with the New Vitros FT3II Assay Reagent
Clin Chem 2004 50: 2218-2219. [Extract] [Full Text] [PDF]

Frank Z. Stanczyk: Extraction/Chromatographic Testosterone RIA Can Be Used as the "Gold Standard" for Determining the Reliability of Direct Testosterone Immunoassay Measurements
Clin Chem 2004 50: 2219-2220. [Extract] [Full Text] [PDF]

David A. Herold and Robert L. Fitzgerald: Drs. Herold and Fitzgerald respond:
Clin Chem 2004 50: 2220-2221. [Extract] [Full Text] [PDF]

Book, Software, and Web Site Reviews:

Theodore Peters, Jr: Life Sciences for the 21st Century. Ehud Keinan, Israel Schechter, and Michael Sela, eds. Weinheim, Germany: Wiley-VCH, 2003, 355 pp., $45.00, hardcover. ISBN 3-527-30588-2.
Clin Chem 2004 50: 2222-2223. [Extract] [Full Text] [PDF]

Pascale F. Macgregor: Exploration and Analysis of DNA Microarray and Protein Array Data. Dhammika Amaratunga and Javier Cabrera. Hoboken, NJ: Wiley-Interscience-John Wiley and Sons, Inc., 2004, 260 pp., $84.95, hardcover. ISBN 0-471-27398-8.
Clin Chem 2004 50: 2222. [Extract] [Full Text] [PDF]

David R. Jacobs and DeAnn Lazovich: Epidemiology Kept Simple: An Introduction to Traditional and Modern Epidemiology, Second Edition. B. Burt Gerstman. Hoboken, NJ: John Wiley & Sons, Inc., 2003, 436 pp., $59.95, paperback. ISBN 0-471-40028-9.
Clin Chem 2004 50: 2223-2224. [Extract] [Full Text] [PDF]

San Diego Conference:

: The San Diego Conference Cool Tools and Hot Applications November 18–20, 2004 San Francisco, CA: Poster Session Abstracts
Clin Chem 2004 50: 2225-2229. [Extract] [Full Text] [PDF]

The Clinical Chemist:

Compiled by David E. Bruns, Editor: Clin Chem 2004 50: 2230-2232. [Extract] [Full Text] [PDF]