Reviews:

Saeed A. Jortani, Sumanth D. Prabhu, and Roland Valdes, Jr

Strategies for Developing Biomarkers of Heart Failure
Clin Chem 2004 50: 265-278. Published online December 4, 2003; 10.1373/clinchem.2003.027557 [Abstract] [Full Text] [PDF]  

Opinion:

Claudio Chiesa, Alessandra Panero, John F. Osborn, Antonella F. Simonetti, and Lucia Pacifico

Diagnosis of Neonatal Sepsis: A Clinical and Laboratory Challenge
Clin Chem 2004 50: 279-287. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Sofie Haglund, Malin Lindqvist, Sven Almer, Curt Peterson, and Jan Taipalensuu

Pyrosequencing of TPMT Alleles in a General Swedish Population and in Patients with Inflammatory Bowel Disease
Clin Chem 2004 50: 288-295. Published online December 4, 2003; 10.1373/clinchem.2003.023846 [Abstract] [Full Text] [PDF] Data Supplement  

Cynthia French, Conan Li, Charles Strom, Weimin Sun, Reuel Van Atta, Belen Gonzalez, and Michael Wood

Detection of the Factor V Leiden Mutation by a Modified Photo-Cross-Linking Oligonucleotide Hybridization Assay
Clin Chem 2004 50: 296-305. Published online December 4, 2003; 10.1373/clinchem.2003.023556 [Abstract] [Full Text] [PDF]  

Stefan S. Biel, Andreas Nitsche, Andreas Kurth, Wolfgang Siegert, Muhsin Özel, and Hans R. Gelderblom

Detection of Human Polyomaviruses in Urine from Bone Marrow Transplant Patients: Comparison of Electron Microscopy with PCR
Clin Chem 2004 50: 306-312. Published online December 18, 2003; 10.1373/clinchem.2003.024539 [Abstract] [Full Text] [PDF]  

Eva Esteban-Cardeñosa, Mercedes Duran, Mar Infante, Eladio Velasco, and Cristina Miner

High-Throughput Mutation Detection Method to Scan BRCA1 and BRCA2 Based on Heteroduplex Analysis by Capillary Array Electrophoresis
Clin Chem 2004 50: 313-320. Published online December 18, 2003; 10.1373/clinchem.2003.023614 [Abstract] [Full Text] [PDF] Data Supplements  

Evidence-based Medicine and Test Utilization:

Peter S. Bunting and Carl van Walraven

Effect of a Controlled Feedback Intervention on Laboratory Test Ordering by Community Physicians
Clin Chem 2004 50: 321-326. Published online December 18, 2003; 10.1373/clinchem.2003.025098 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Mauro Panteghini, Franca Pagani, Kiang-Teck J. Yeo, Fred S. Apple, Robert H. Christenson, Francesco Dati, Johannes Mair, Jan Ravkilde, and Alan H.B. Wu

Evaluation of Imprecision for Cardiac Troponin Assays at Low-Range Concentrations
Clin Chem 2004 50: 327-332. Published online December 4, 2003; 10.1373/clinchem.2003.026815 [Abstract] [Full Text] [PDF]  

Joseph C. Lin, Fred S. Apple, MaryAnn M. Murakami, and Russell V. Luepker

Rates of Positive Cardiac Troponin I and Creatine Kinase MB Mass among Patients Hospitalized for Suspected Acute Coronary Syndromes
Clin Chem 2004 50: 333-338. Published online December 11, 2003; 10.1373/clinchem.2003.026708 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Sing-fai Leung, John S. Tam, Anthony T.C. Chan, Benny Zee, Lisa Y.S. Chan, Dolly P. Huang, Andrew Van Hasselt, Philip J. Johnson, and Y.M. Dennis Lo

Improved Accuracy of Detection of Nasopharyngeal Carcinoma by Combined Application of Circulating Epstein–Barr Virus DNA and Anti-Epstein–Barr Viral Capsid Antigen IgA Antibody
Clin Chem 2004 50: 339-345. Published online December 18, 2003; 10.1373/clinchem.2003.022426 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Maria Averina, Odd Nilssen, Tormod Brenn, Jan Brox, Vadim L. Arkhipovsky, and Alexei G. Kalinin

Factors behind the Increase in Cardiovascular Mortality in Russia: Apolipoprotein AI and B Distribution in the Arkhangelsk Study 2000
Clin Chem 2004 50: 346-354. Published online December 18, 2003; 10.1373/clinchem.2003.023853 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Norbert Baume, Lidia Avois, Carine Schweizer, Christine Cardis, Jiri Dvorak, Michel Cauderay, Patrice Mangin, and Martial Saugy

[¹³C]Nandrolone Excretion in Trained Athletes: Interindividual Variability in Metabolism
Clin Chem 2004 50: 355-364. Published online November 21, 2003; 10.1373/clinchem.2003.022848 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Sally P. Stabler and Robert H. Allen

Quantification of Serum and Urinary S-Adenosylmethionine and S-Adenosylhomocysteine by Stable-Isotope-Dilution Liquid Chromatography-Mass Spectrometry
Clin Chem 2004 50: 365-372. Published online December 4, 2003; 10.1373/clinchem.2003.026252 [Abstract] [Full Text] [PDF]  

Robert E. Nelson, Stefan K. Grebe, Dennis J. O’Kane, and Ravinder J. Singh

Liquid Chromatography–Tandem Mass Spectrometry Assay for Simultaneous Measurement of Estradiol and Estrone in Human Plasma
Clin Chem 2004 50: 373-384. Published online December 4, 2003; 10.1373/clinchem.2003.025478 [Abstract] [Full Text] [PDF]  

Masaaki Inaba, Kiyoshi Nakatsuka, Yasuo Imanishi, Masakazu Watanabe, Yuji Mamiya, Eiji Ishimura, and Yoshiki Nishizawa

Technical and Clinical Characterization of the Bio-PTH (1–84) Immunochemiluminometric Assay and Comparison with a Second-Generation Assay for Parathyroid Hormone
Clin Chem 2004 50: 385-390. Published online December 18, 2003; 10.1373/clinchem.2003.026831 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Klaus Meyer, Åse Fredriksen, and Per Magne Ueland

High-Level Multiplex Genotyping of Polymorphisms Involved in Folate or Homocysteine Metabolism by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
Clin Chem 2004 50: 391-402. [Abstract] [Full Text] [PDF]  

Fredoen Valianpour, Nicolaas G.G.M. Abeling, Marinus Duran, Jan G.M. Huijmans, and Willem Kulik

Quantification of Free Sialic Acid in Urine by HPLC–Electrospray Tandem Mass Spectrometry: A Tool for the Diagnosis of Sialic Acid Storage Disease
Clin Chem 2004 50: 403-409. Published online December 18, 2003; 10.1373/clinchem.2003.027169 [Abstract] [Full Text] [PDF] Data Suppplement  

Françoise Lasne, Nathalie Crepin, Michael Ashenden, Michel Audran, and Jacques de Ceaurriz

Detection of Hemoglobin-Based Oxygen Carriers in Human Serum for Doping Analysis: Screening by Electrophoresis
Clin Chem 2004 50: 410-415. Published online November 21, 2003; 10.1373/clinchem.2003.026583 [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Yanfei Feng, Xue Ke, Rongshui Ma, Ying Chen, Gengxi Hu, and Feizhou Liu

Parallel Detection of Autoantibodies with Microarrays in Rheumatoid Diseases
Clin Chem 2004 50: 416-422. Published online December 11, 2003; 10.1373/clinchem.2003.023994 [Abstract] [Full Text] [PDF]  

Nutrition:

Christine M. Pfeiffer, Zia Fazili, Les McCoy, Ming Zhang, and Elaine W. Gunter

Determination of Folate Vitamers in Human Serum by Stable-Isotope-Dilution Tandem Mass Spectrometry and Comparison with Radioassay and Microbiologic Assay
Clin Chem 2004 50: 423-432. Published online December 11, 2003; 10.1373/clinchem.2003.026955 [Abstract] [Full Text] [PDF] Data Supplement  

Technical Briefs:

Steven C. Kazmierczak, Alex F. Robertson, Kimberly P. Briley, Bill Kreamer, and Glenn R. Gourley

Transcutaneous Measurement of Bilirubin in Newborns: Comparison with an Automated Jendrassik–Grof Procedure and HPLC
Clin Chem 2004 50: 433-435. [Extract] [Full Text] [PDF]  

Adriana P. Schmidt, Adriano B.L. Tort, Olavo B. Amaral, André P. Schmidt, Roger Walz, Janete Vettorazzi-Stuckzynski, Sérgio H. Martins-Costa, José Geraldo L. Ramos, Diogo O. Souza, and Luis V.C. Portela

Serum S100B in Pregnancy-Related Hypertensive Disorders: A Case–Control Study
Clin Chem 2004 50: 435-438. [Extract] [Full Text] [PDF]  

Maria Shipkova, Paul Dieter Niedmann, Victor W. Armstrong, Michael Oellerich, and Eberhard Wieland

Determination of Thiopurine Methyltransferase Activity in Isolated Human Erythrocytes Does Not Reflect Putative in Vivo Enzyme Inhibition by Sulfasalazine
Clin Chem 2004 50: 438-441. [Extract] [Full Text] [PDF]  

Nanda M. Verhoeven, Birthe Roos, Eduard A. Struys, Gajja S. Salomons, Marjo S. van der Knaap, and Cornelis Jakobs

Enzyme Assay for Diagnosis of Guanidinoacetate Methyltransferase Deficiency
Clin Chem 2004 50: 441-443. [Extract] [Full Text] [PDF]  

Amar Akhtar Sethi, Anne Tybjærg-Hansen, Rolf Værn Andersen, and Børge Grønne Nordestgaard

Nanogen Microelectronic Chip for Large-Scale Genotyping
Clin Chem 2004 50: 443-446. [Extract] [Full Text] [PDF] Data Supplement  

Haruo Takeshita, Tamiko Nakajima, Kouichi Mogi, Yasushi Kaneko, Toshihiro Yasuda, Reiko Iida, and Koichiro Kishi

Rapid Quantification of DNase I Activity in One-Microliter Serum Samples
Clin Chem 2004 50: 446-448. [Extract] [Full Text] [PDF]  

Konstanze Diefenbach, Farhad Arjomand Nahad, Christian Meisel, Ingo Fietze, Ingolf Cascorbi, Karl Stangl, Olfert Landt, Reinhold Kerb, Ulrich Brinkmann, and Ivar Roots

Identification of Twelve Polymorphisms in the Endothelin-1 Gene by Use of Fluorescently Labeled Oligonucleotides and PCR with Restriction Fragment Polymorphism Analysis
Clin Chem 2004 50: 448-451. [Extract] [Full Text] [PDF] Data Supplement  

M Jesus Llorente, Mercedes Sebastián, M Jesus Fernández-Aceñero, Gemma Prieto, and Santiago Villanueva

IgA Antibodies against Tissue Transglutaminase in the Diagnosis of Celiac Disease: Concordance with Intestinal Biopsy in Children and Adults
Clin Chem 2004 50: 451-453. [Extract] [Full Text] [PDF] Data Supplement  

Letters to the Editor:

Alfons Gegenhuber, Thomas Mueller, Fritz Firlinger, Kurt Lenz, Werner Poelz, and Meinhard Haltmayer

Time Course of B-Type Natriuretic Peptide (BNP) and N-Terminal ProBNP Changes in Patients with Decompensated Heart Failure
Clin Chem 2004 50: 454-456. [Extract] [Full Text] [PDF]  

Henrique M.G. Pereira, Marlice A.S. Marques, Isadora B. Talhas, and Francisco Radler Aquino Neto

Incidental Clostebol Contamination in Athletes after Sexual Intercourse
Clin Chem 2004 50: 456-457. [Extract] [Full Text] [PDF]  

Michael Gröschl, Manfred Uhr, and Thomas Kraus

Evaluation of the Comparability of Commercial Ghrelin Assays
Clin Chem 2004 50: 457-458. [Extract] [Full Text] [PDF]  

Lenette Walters

Beckman Coulter Access Creatine Kinase MB Assay
Clin Chem 2004 50: 458. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Jan K. Labanowski

Perl Programming for Biologists. D. Curtis Jamison. Hoboken, NJ: Wiley-Liss, A John Wiley Sons Publication, 2003, 202 pp., $42.95, softcover. ISBN 0471-43059-5.
Clin Chem 2004 50: 459-460. [Extract] [Full Text] [PDF]  

Sandra Clejan

Neonatology & Laboratory Medicine. Anne Green, Imogen Morgan, and Jim Gray. London, UK: ACB Venture Publications, 2003, 328 pp., £24. ISBN 0-902429-41-8.
Clin Chem 2004 50: 460. [Extract] [Full Text] [PDF]  

Corrections:

Correction for Volume 48, Issue , p. 939
Clin Chem 2004 50: 461. [Extract] [Full Text] [PDF]  

Correction for Volume 49, Issue , p. 719
Clin Chem 2004 50: 461. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2004 50: 462-463. [Extract] [Full Text] [PDF]  

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