Editorials:

William E. Winter

A Rosetta Stone for Insulin Treatment: Self-Monitoring of Blood Glucose
Clin Chem 2004 50: 985-987. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Zeliang Chen, Decui Pei, Lingxiao Jiang, Yajun Song, Jin Wang, Hongxia Wang, Dongsheng Zhou, Junhui Zhai, Zongmin Du, Bei Li, Maofeng Qiu, Yanping Han, Zhaobiao Guo, and Ruifu Yang

Antigenicity Analysis of Different Regions of the Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein
Clin Chem 2004 50: 988-995. Published online March 30, 2004; 10.1373/clinchem.2004.031096 [Abstract] [Full Text] [PDF] Data Supplement  

Ren-Kui Bai and Lee-Jun C. Wong

Detection and Quantification of Heteroplasmic Mutant Mitochondrial DNA by Real-Time Amplification Refractory Mutation System Quantitative PCR Analysis: A Single-Step Approach
Clin Chem 2004 50: 996-1001. Published online April 8, 2004; 10.1373/clinchem.2004.031153 [Abstract] [Full Text] [PDF]  

Ying Li, Bernhard Zimmermann, Corinne Rusterholz, Anjeung Kang, Wolfgang Holzgreve, and Sinuhe Hahn

Size Separation of Circulatory DNA in Maternal Plasma Permits Ready Detection of Fetal DNA Polymorphisms
Clin Chem 2004 50: 1002-1011. Published online April 8, 2004; 10.1373/clinchem.2003.029835 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Andrew W. Roddam, Christopher P. Price, Naomi E. Allen, and Anthony Milford Ward

Assessing the Clinical Impact of Prostate-Specific Antigen Assay Variability and Nonequimolarity: A Simulation Study Based on the Population of the United Kingdom
Clin Chem 2004 50: 1012-1016. Published online March 18, 2004; 10.1373/clinchem.2004.031138 [Abstract] [Full Text] [PDF]  

Stephen D. Mikolajczyk, William J. Catalona, Cindy L. Evans, Harry J. Linton, Lisa S. Millar, Kathy M. Marker, Diksha Katir, Anna Amirkhan, and Harry G. Rittenhouse

Proenzyme Forms of Prostate-Specific Antigen in Serum Improve the Detection of Prostate Cancer
Clin Chem 2004 50: 1017-1025. Published online March 30, 2004; 10.1373/clinchem.2003.026823 [Abstract] [Full Text] [PDF]  

Point-of-Care Testing:

Piia von Lode, Jarmo Rainaho, and Kim Pettersson

Quantitative, Wide-Range, 5-Minute Point-of-Care Immunoassay for Total Human Chorionic Gonadotropin in Whole Blood
Clin Chem 2004 50: 1026-1035. Published online April 8, 2004; 10.1373/clinchem.2004.031922 [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Wai-Yan Choy, Shu-Guang Lin, Paul Kay-Sheung Chan, John Siu-Lun Tam, Y.M. Dennis Lo, Ida Miu-Ting Chu, Sau-Na Tsai, Ming-Qi Zhong, Kwok-Pui Fung, Mary Miu-Yee Waye, Stephen Kwok-Wing Tsui, Kai-On Ng, Zhi-Xin Shan, Min Yang, Yi-Long Wu, Zhan-Yi Lin, and Sai-Ming Ngai

Synthetic Peptide Studies on the Severe Acute Respiratory Syndrome (SARS) Coronavirus Spike Glycoprotein: Perspective for SARS Vaccine Development
Clin Chem 2004 50: 1036-1042. Published online March 25, 2004; 10.1373/clinchem.2003.029801 [Abstract] [Full Text] [PDF]  

Nutrition:

Mustafa Vakur Bor, Ebba Nexø, and Anne-Mette Hvas

Holo-Transcobalamin Concentration and Transcobalamin Saturation Reflect Recent Vitamin B₁₂ Absorption Better than Does Serum Vitamin B₁₂
Clin Chem 2004 50: 1043-1049. Published online March 25, 2004; 10.1373/clinchem.2003.027458 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Leo L.M. Poon, Cynthia S.W. Leung, Masato Tashiro, Kwok Hung Chan, Bonnie W.Y. Wong, Kwok Yung Yuen, Yi Guan, and Joseph S.M. Peiris

Rapid Detection of the Severe Acute Respiratory Syndrome (SARS) Coronavirus by a Loop-Mediated Isothermal Amplification Assay
Clin Chem 2004 50: 1050-1052. Published online March 30, 2004; 10.1373/clinchem.2004.032011 [Extract] [Full Text] [PDF] Data Supplement  

Sunga Choi, Eui Yul Choi, Ha Suck Kim, and Sang Wook Oh

On-Site Quantification of Human Urinary Albumin by a Fluorescence Immunoassay
Clin Chem 2004 50: 1052-1055. [Extract] [Full Text] [PDF] Data Supplement  

Enders K.O. Ng, Ahmad El-Sheikhah, Rossa W.K. Chiu, K.C. Allen Chan, Matthew Hogg, Renu Bindra, Tse N. Leung, Tze K. Lau, Kypros H. Nicolaides, and Y.M. Dennis Lo

Evaluation of Human Chorionic Gonadotropin ß-Subunit mRNA Concentrations in Maternal Serum in Aneuploid Pregnancies: A Feasibility Study
Clin Chem 2004 50: 1055-1057. [Extract] [Full Text] [PDF]  

Bi-feng Yuan, Yu-hua Hao, and Zheng Tan

Universal Sensing Strategy for the Detection of Nucleic Acid Targets by Optical Biosensor Based on Surface Plasmon Resonance
Clin Chem 2004 50: 1057-1060. [Extract] [Full Text] [PDF] Data Supplement  

Mandira Varma-Basil, Hiyam El-Hajj, Salvatore A.E. Marras, Manzour Hernando Hazbón, Jessica M. Mann, Nancy D. Connell, Fred Russell Kramer, and David Alland

Molecular Beacons for Multiplex Detection of Four Bacterial Bioterrorism Agents
Clin Chem 2004 50: 1060-1062. [Extract] [Full Text] [PDF]  

Edgar Zapico-Muñiz, Miquel Santaló-Bel, Javier Mercé-Muntañola, José A. Montiel, Antonio Martínez-Rubio, and Jordi Ordóñez-Llanos

Ischemia-Modified Albumin during Skeletal Muscle Ischemia
Clin Chem 2004 50: 1063-1065. [Extract] [Full Text] [PDF]  

Hannes M. Müller, Lennart Ivarsson, Hans Schröcksnadel, Heidi Fiegl, Andreas Widschwendter, Georg Goebel, Susanne Kilga-Nogler, Horst Philadelphy, Wolfgang Gütter, Christian Marth, and Martin Widschwendter

DNA Methylation Changes in Sera of Women in Early Pregnancy Are Similar to Those in Advanced Breast Cancer Patients
Clin Chem 2004 50: 1065-1068. [Extract] [Full Text] [PDF]  

Gunn B.B. Kristensen, Kari Nerhus, Geir Thue, and Sverre Sandberg

Standardized Evaluation of Instruments for Self-Monitoring of Blood Glucose by Patients and a Technologist
Clin Chem 2004 50: 1068-1071. [Extract] [Full Text] [PDF] Data Supplement  

Hans Günther Wahl, Stephanie Graf, Harald Renz, and Winfried Fassbinder

Elimination of the Cardiac Natriuretic Peptides B-Type Natriuretic Peptide (BNP) and N-Terminal proBNP by Hemodialysis
Clin Chem 2004 50: 1071-1074. [Extract] [Full Text] [PDF]  

Hsien-Hsiung Lee, Yann-Jinn Lee, Peter Chan, and Ching-Yu Lin

Use of PCR-Based Amplification Analysis as a Substitute for the Southern Blot Method for CYP21 Deletion Detection in Congenital Adrenal Hyperplasia
Clin Chem 2004 50: 1074-1076. [Extract] [Full Text] [PDF]  

Hiroshi Hosoda, Kentaro Doi, Noritoshi Nagaya, Hiroyuki Okumura, Eiichiro Nakagawa, Mitsunobu Enomoto, Fumiaki Ono, and Kenji Kangawa

Optimum Collection and Storage Conditions for Ghrelin Measurements: Octanoyl Modification of Ghrelin Is Rapidly Hydrolyzed to Desacyl Ghrelin in Blood Samples
Clin Chem 2004 50: 1077-1080. [Extract] [Full Text] [PDF] Data Supplement  

Kendall W. Cradic, Jason E. Wells, Lindsay Allen, Kent E. Kruckeberg, Ravinder J. Singh, and Stefan K.G. Grebe

Substitution of 3'-Phosphate Cap with a Carbon-Based Blocker Reduces the Possibility of Fluorescence Resonance Energy Transfer Probe Failure in Real-Time PCR Assays
Clin Chem 2004 50: 1080-1082. [Extract] [Full Text] [PDF]  

Manuel Salto-Tellez, Soo Chin Lee, Lily L. Chiu, Chi Kuen Lee, May Chin Yong, and Evelyn S.C. Koay

Microsatellite Instability in Colorectal Cancer: Considerations for Molecular Diagnosis and High-Throughput Screening of Archival Tissues
Clin Chem 2004 50: 1082-1086. [Extract] [Full Text] [PDF] Data Supplement  

Emersom S. Lima and Raul C. Maranhão

Rapid, Simple Laser-Light-Scattering Method for HDL Particle Sizing in Whole Plasma
Clin Chem 2004 50: 1086-1088. [Extract] [Full Text] [PDF]  

Pascual Bolufer, Dolors Colomer, Maria T. Gomez, Joaquín Martínez, Silvia M. Gonzalez, Marcos Gonzalez, Josep Nomdedeu, Beatriz Bellosillo, Eva Barragán, Francesco Lo-Coco, Daniela Diverio, Lourdes Hermosin, José García-Marco, Maria D. de Juan, Francisco Barros, Rafael Romero, and Miguel A. Sanz

Quantitative Assessment of PML-RARa and BCR-ABL by Two Real-Time PCR Instruments: Multiinstitutional Laboratory Trial
Clin Chem 2004 50: 1088-1092. [Extract] [Full Text] [PDF] Data Supplement  

Glen L. Hortin, Bonnie Meilinger, and Steven K. Drake

Size-Selective Extraction of Peptides from Urine for Mass Spectrometric Analysis
Clin Chem 2004 50: 1092-1095. [Extract] [Full Text] [PDF]  

Sayed M.H. Sadrzadeh, Yasi Saffari, and Jafar Bozorgmehr

Haptoglobin Phenotypes in Epilepsy
Clin Chem 2004 50: 1095-1097. [Extract] [Full Text] [PDF] Data Supplement  

Hanneke W.M. van Laarhoven, Jacques J. Willemsen, H. Alec Ross, Louk V.A.M. Beex, Jacques W.M. Lenders, and Fred C.G.J. Sweep

Pitfall in HPLC Assay for Urinary Metanephrines: An Unusual Type of Interference Caused by Methenamine Intake
Clin Chem 2004 50: 1097-1099. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Youssef Ibrahim, Martin Volkmann, Racha Hassoun, Walter Fiehn, Heidi Rossmann, Stanley S. Levinson, and Ronald J. Elin

Serum Protein Electrophoresis: Reptilase Treatment Is Superior to Ethanol Precipitation for Specific Removal of Fibrinogen from Heparinized Plasma Samples • Drs. Levinson and Elin respond:
Clin Chem 2004 50: 1100-1101. [Extract] [Full Text] [PDF]  

Susann Eriksson and Kim Pettersson

The Interfering Component in Cardiac Troponin I Immunoassays
Clin Chem 2004 50: 1101-1102. [Extract] [Full Text] [PDF]  

Martin Fenske

How Much "Urinary Free Cortisol" Is Really Cortisol during Water Diuresis in Healthy Individuals?
Clin Chem 2004 50: 1102-1104. [Extract] [Full Text] [PDF]  

Thomas Mueller, Alfons Gegenhuber, Werner Poelz, and Meinhard Haltmayer

Preliminary Evaluation of the AxSYM B-Type Natriuretic Peptide (BNP) Assay and Comparison with the ADVIA Centaur BNP Assay
Clin Chem 2004 50: 1104-1106. [Extract] [Full Text] [PDF]  

Goce Dimeski and Alan E. Clague

Bicarbonate Interference with Chloride-Ion-Selective Electrodes
Clin Chem 2004 50: 1106-1107. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Alan L. Rockwood

The Expanding Role of Mass Spectrometry in Biotechnology. Gary Siuzdak. San Diego, CA: MCC Press, 2003, 286 pp., $49.00, softcover. ISBN 0-9742451-0-0.
Clin Chem 2004 50: 1108-1109. [Extract] [Full Text] [PDF]  

Reed E. Pyeritz

What Genes Can’t Do. Lenny Moss. Cambridge, MA: The MIT Press, 2003, 228 pp., $34.95, hardcover. ISBN 0-262-13411-X.
Clin Chem 2004 50: 1109-1110. [Extract] [Full Text] [PDF]  

W. Edward Highsmith

Essentials of Medical Genomics. Stuart M. Brown, with contributions by John G. Hay and Harry Ostrer. Hoboken, NJ: Wiley-Liss, Inc., 2003, 256 pp., $89.95, hardcover. ISBN 0-471-21003-X.
Clin Chem 2004 50: 1110-1111. [Extract] [Full Text] [PDF]  

Corrections:

Clin Chem 2004 50: 1111. [Extract] [Full Text] [PDF]  

Correction for Volume 50, Issue , p. 559
Clin Chem 2004 50: 1111. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Joris Delanghe and Jan Philippé

Clin Chem 2004 50: 1112. [Extract] [Full Text] [PDF]  

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