Editorials:

Milada Dobiásová

Atherogenic Index of Plasma [Log(Triglycerides/HDL-Cholesterol)]: Theoretical and Practical Implications
Clin Chem 2004 50: 1113-1115. [Extract] [Full Text] [PDF]  

John W. Baynes

The Clinical Chemome: A Tool for the Diagnosis and Management of Chronic Disease
Clin Chem 2004 50: 1116-1117. [Extract] [Full Text] [PDF]  

Reviews:

Nancy A. Obuchowski, Michael L. Lieber, and Frank H. Wians, Jr.

ROC Curves in Clinical Chemistry: Uses, Misuses, and Possible Solutions
Clin Chem 2004 50: 1118-1125. Published online May 13, 2004; 10.1373/clinchem.2004.031823 [Abstract] [Full Text] [PDF]  

Lori J. Sokoll, Frank H. Wians, Jr, and Alan T. Remaley

Rapid Intraoperative Immunoassay of Parathyroid Hormone and Other Hormones: A New Paradigm for Point-of-Care Testing
Clin Chem 2004 50: 1126-1135. Published online April 29, 2004; 10.1373/clinchem.2003.030817 [Abstract] [Full Text] [PDF]  

Steven W. Heim, Joel M. Schectman, Mir S. Siadaty, and John T. Philbrick

D-Dimer Testing for Deep Venous Thrombosis: A Metaanalysis
Clin Chem 2004 50: 1136-1147. Published online May 13, 2004; 10.1373/clinchem.2004.031765 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Alessia Bagattin, Caterina Veronese, Barbara Bauce, Wim Wuyts, Luca Settimo, Andrea Nava, Alessandra Rampazzo, and Gian Antonio Danieli

Denaturing HPLC-Based Approach for Detecting RYR2 Mutations Involved in Malignant Arrhythmias
Clin Chem 2004 50: 1148-1155. Published online May 6, 2004; 10.1373/clinchem.2003.030734 [Abstract] [Full Text] [PDF] Data Supplement  

Michael Liew, Robert Pryor, Robert Palais, Cindy Meadows, Maria Erali, Elaine Lyon, and Carl Wittwer

Genotyping of Single-Nucleotide Polymorphisms by High-Resolution Melting of Small Amplicons
Clin Chem 2004 50: 1156-1164. [Abstract] [Full Text] [PDF] Data Supplement  

Pascale Saussoy, Jean-Luc Vaerman, Nicole Straetmans, Véronique Deneys, Guy Cornu, Augustin Ferrant, and Dominique Latinne

Differentiation of Acute Myeloid Leukemia from B- and T-Lineage Acute Lymphoid Leukemias by Real-Time Quantitative Reverse Transcription-PCR of Lineage Marker mRNAs
Clin Chem 2004 50: 1165-1173. [Abstract] [Full Text] [PDF] Data Supplement  

Automation and Analytical Techniques:

Sichun Zhang, Chao Zhang, Zhi Xing, and Xinrong Zhang

Simultaneous Determination of -Fetoprotein and Free ß-Human Chorionic Gonadotropin by Element-Tagged Immunoassay with Detection by Inductively Coupled Plasma Mass Spectrometry
Clin Chem 2004 50: 1214-1221. Published online April 29, 2004; 10.1373/clinchem.2003.029850 [Abstract] [Full Text] [PDF]  

Tom Teerlink, Rob Barto, Herman J. ten Brink, and Casper G. Schalkwijk

Measurement of N-(Carboxymethyl)lysine and N-(Carboxyethyl)lysine in Human Plasma Protein by Stable-Isotope-Dilution Tandem Mass Spectrometry
Clin Chem 2004 50: 1222-1228. Published online May 6, 2004; 10.1373/clinchem.2004.031286 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Angelika Hammerer-Lercher, Wilma Ludwig, Gerda Falkensammer, Silvana Müller, Elke Neubauer, Bernd Puschendorf, Otmar Pachinger, and Johannes Mair

Natriuretic Peptides as Markers of Mild Forms of Left Ventricular Dysfunction: Effects of Assays on Diagnostic Performance of Markers
Clin Chem 2004 50: 1174-1183. Published online May 13, 2004; 10.1373/clinchem.2003.028316 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Meng H. Tan, Don Johns, and N. Bradly Glazer

Pioglitazone Reduces Atherogenic Index of Plasma in Patients with Type 2 Diabetes
Clin Chem 2004 50: 1184-1188. Published online April 29, 2004; 10.1373/clinchem.2004.031757 [Abstract] [Full Text] [PDF]  

David S. Freedman, James D. Otvos, Elias J. Jeyarajah, Irina Shalaurova, L. Adrienne Cupples, Helen Parise, Ralph B. D’Agostino, Peter W.F. Wilson, and Ernst J. Schaefer

Sex and Age Differences in Lipoprotein Subclasses Measured by Nuclear Magnetic Resonance Spectroscopy: The Framingham Study
Clin Chem 2004 50: 1189-1200. Published online April 23, 2004; 10.1373/clinchem.2004.032763 [Abstract] [Full Text] [PDF]  

Michael Y. Tsai, Angeliki Georgopoulos, James D. Otvos, Jose M. Ordovas, Naomi Q. Hanson, James M. Peacock, and Donna K. Arnett

Comparison of Ultracentrifugation and Nuclear Magnetic Resonance Spectroscopy in the Quantification of Triglyceride-Rich Lipoproteins after an Oral Fat Load
Clin Chem 2004 50: 1201-1204. Published online May 13, 2004; 10.1373/clinchem.2004.032938 [Abstract] [Full Text] [PDF]  

Hematology:

Simona Soverini, Giovanni Martinelli, Marilina Amabile, Angela Poerio, Michele Bianchini, Gianantonio Rosti, Fabrizio Pane, Giuseppe Saglio, and Michele Baccarani

Denaturing-HPLC-Based Assay for Detection of ABL Mutations in Chronic Myeloid Leukemia Patients Resistant to Imatinib
Clin Chem 2004 50: 1205-1213. Published online April 23, 2004; 10.1373/clinchem.2004.031112 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Qinghong Han, Mingxu Xu, Li Tang, Xinghua Sun, Nan Zhang, Xuezhong Tan, Xiuying Tan, Yuying Tan, and Robert M. Hoffman

Homogeneous Enzymatic Colorimetric Assay for Total Cysteine
Clin Chem 2004 50: 1229-1231. [Extract] [Full Text] [PDF]  

Hong Xie, Yuan Hong Yu, Fang Xie, Yuan Zhi Lao, and Zhiqiang Gao

Breast Cancer Susceptibility Gene mRNAs Quantified by Microarrays with Electrochemical Detection
Clin Chem 2004 50: 1231-1233. [Extract] [Full Text] [PDF] Data Supplement  

Julie A.E. Irving, Stephen O’Brien, Anne L. Lennard, Lynne Minto, Feng Lin, and Andrew G. Hall

Use of Denaturing HPLC for Detection of Mutations in the BCR-ABL Kinase Domain in Patients Resistant to Imatinib
Clin Chem 2004 50: 1233-1237. [Extract] [Full Text] [PDF]  

Haibin Wang, Yuanli Mao, Liancai Ju, Jing Zhang, Zhiguo Liu, Xianzhi Zhou, Qinghong Li, Yuedong Wang, Sunghee Kim, and Lurong Zhang

Detection and Monitoring of SARS Coronavirus in the Plasma and Peripheral Blood Lymphocytes of Patients with Severe Acute Respiratory Syndrome
Clin Chem 2004 50: 1237-1240. [Extract] [Full Text] [PDF] Data Supplement  

Susanne Franck, Jo Linssen, Maren Messinger, and Lothar Thomas

Potential Utility of Ret-Y in the Diagnosis of Iron-Restricted Erythropoiesis
Clin Chem 2004 50: 1240-1242. [Extract] [Full Text] [PDF]  

Valentina Guida, Alessia Colosimo, Mirella Fiorito, Enrica Foglietta, Ida Bianco, Giovanni Ivaldi, Marco Fichera, and Bruno Dallapiccola

Denaturing HPLC-Based Assay for Molecular Screening of Nondeletional Mutations Causing -Thalassemias
Clin Chem 2004 50: 1242-1245. [Extract] [Full Text] [PDF]  

Carol M. Preissner, William M. Reilly, Richard C. Cyr, Dennis J. O’Kane, Ravinder J. Singh, and Stefan K.G. Grebe

Plastic versus Glass Tubes: Effects on Analytical Performance of Selected Serum and Plasma Hormone Assays
Clin Chem 2004 50: 1245-1247. [Extract] [Full Text] [PDF] Data supplement  

Stefano A. Santini, Cinzia Carrozza, Carlo Vulpio, Ettore Capoluongo, Giovanna Luciani, Paola Lulli, Bruno Giardina, and Cecilia Zuppi

Assessment of Parathyroid Function in Clinical Practice: Which Parathyroid Hormone Assay Is Better?
Clin Chem 2004 50: 1247-1250. [Extract] [Full Text] [PDF] Data Supplement  

Sylvie Faucher, Alexandre Martel, Alice Sherring, Tao Ding, Laurie Malloch, John E. Kim, Michèle Bergeron, Paul Sandstrom, and Francis F. Mandy

Protein Bead Array for the Detection of HIV-1 Antibodies from Fresh Plasma and Dried-Blood-Spot Specimens
Clin Chem 2004 50: 1250-1253. [Extract] [Full Text] [PDF] Data Supplement  

Kleopatra H. Schulpis, Theodoros Karakonstantakis, Stavroula Gavrili, Christos Costalos, Eleftheria Roma, and Ioannis Papassotiriou

Serum Copper Is Decreased in Premature Newborns and Increased in Newborns with Hemolytic Jaundice
Clin Chem 2004 50: 1253-1256. [Extract] [Full Text] [PDF] Data Supplement  

Andrej-Nikolai Spiess, Nadine Mueller, and Richard Ivell

Trehalose Is a Potent PCR Enhancer: Lowering of DNA Melting Temperature and Thermal Stabilization of Taq Polymerase by the Disaccharide Trehalose,
Clin Chem 2004 50: 1256-1259. [Extract] [Full Text] [PDF]  

Dimitrios Tsikas

Mass Spectrometry-Validated HPLC Method for Urinary Nitrate
Clin Chem 2004 50: 1259-1261. [Extract] [Full Text] [PDF]  

Joseph T. Chang, Fen-Hwa Wong, Chun-Ta Liao, I-How Chen, Hung-Ming Wang, and Ann-Joy Cheng

Enzyme Immunoassay for Serum Autoantibody to Survivin and Its Findings in Head-and-Neck Cancer Patients
Clin Chem 2004 50: 1261-1264. [Extract] [Full Text] [PDF] Data Supplement  

Richard Brans, Danute Laizane, Annika Khan, and Brunhilde Blömeke

N-Acetyltransferase 2 Genotyping: An Accurate and Feasible Approach for Simultaneous Detection of the Most Common NAT2 Alleles
Clin Chem 2004 50: 1264-1266. [Extract] [Full Text] [PDF]  

Adie Viljoen, Simon W. Walker, Kay S. Walker, and Patrick J. Twomey

Imprecision of Cerebrospinal Fluid Net Bilirubin Absorbance
Clin Chem 2004 50: 1266-1268. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Catherine Costa, Jean-Marie Jouannic, Nathalie Stieltjes, Jean-Marc Costa, Emmanuelle Girodon, and Michel Goossens

Quantitative Real-Time PCR Assay for Rapid Identification of Deletion Carriers in Hemophilia
Clin Chem 2004 50: 1269-1270. [Extract] [Full Text] [PDF]  

Mostafa Rafat, Alexander M. Sattler, Rolf Hackler, Mouhidien Soufi, Armin Steinmetz, Bernhard Maisch, and Juergen R. Schaefer

Apolipoprotein A-IV in the Fed and Fasting States
Clin Chem 2004 50: 1270-1271. [Extract] [Full Text] [PDF]  

Franca Pagani, Francesca Stefini, and Mauro Panteghini

Innotrac Aio! Second-Generation Cardiac Troponin I Assay: Imprecision Profile and Other Key Characteristics for Clinical Use
Clin Chem 2004 50: 1271-1272. [Extract] [Full Text] [PDF]  

Siegmund L. Braun, Kathrin Ciolek, and Wolfgang Vogt

Early Detection of the Selectivity Loss of the Cobas Integra Analyzer Chloride Ion-Selective Electrode
Clin Chem 2004 50: 1272-1273. [Extract] [Full Text] [PDF]  

Linda Lambert, John Caban, Dennis W. Jay, Neil Greenberg, Thomas A. Smith, and Nicholas VanBrunt

Interference in the Vitros CREA Method When Measuring Urine Creatinine on Samples Acidified with Acetic Acid • Representatives of Ortho-Clinical Diagnostics respond:
Clin Chem 2004 50: 1273-1275. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Kristian A. Thygesen

Cardiac Markers, 2nd ed. Alan H.B. Wu, editor. Totowa, NJ: Humana Press, 2003, 484 pp., $145.00, hardcover. ISBN 1-58829-036-0.
Clin Chem 2004 50: 1276-1277. [Extract] [Full Text] [PDF]  

Alan T. Remaley

Proteomic and Genomic Analysis of Cardiovascular Disease. Jennifer E. Van Eyk and Michael J. Dunn, editors. Weinheim, Federal Republic of Germany: Wiley-VCH Verlag GmbH & Co., 2003, 424 pp., $95.00, hardcover. ISBN 3-527-30596-3.
Clin Chem 2004 50: 1276. [Extract] [Full Text] [PDF]  

Nancy A. Wiley

A Pair of Medical Terminology Primers: Quick & Easy Medical Terminology, 4th edition. Peggy C. Leonard. Philadelphia: Saunders, Elsevier Science, 2003, 400 pp. (with CD-ROM and audiotape), $36.95. ISBN 0-7216-9624-4. Medical Terminology: A Short Course, 3rd edition. Davi-Ellen Chabner. Philadelphia, PA: W.B. Saunders Co., 2003, 336 pp. (with CD-ROM), $19.95. ISBN 0-7216-9824-7.
Clin Chem 2004 50: 1277. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2004 50: 1279-1288. [Extract] [Full Text] [PDF]  

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