Editorials:

David A. Morrow

Preprocedural C-Reactive Protein for Risk Prediction Before Percutaneous Coronary Intervention (PCI): A US Perspective
Clin Chem 2004 50: 1489-1491. [Extract] [Full Text] [PDF]  

Luigi M. Biasucci and Giuseppe G.L. Biondi-Zoccai

Preprocedural C-Reactive Protein for Risk Prediction Before Percutaneous Coronary Intervention (PCI): A European Perspective
Clin Chem 2004 50: 1492-1494. [Extract] [Full Text] [PDF]  

Allan S. Jaffe, Fred S. Apple, and Luciano Babuin

Why We Don’t Know the Answer May Be More Important than the Specific Question
Clin Chem 2004 50: 1495-1497. [Extract] [Full Text] [PDF]  

Roland Valdes, Jr and Mark W. Linder

Fine-Tuning Pharmacogenetics: Paradigm for Linking Laboratory Results to Clinical Action
Clin Chem 2004 50: 1498-1499. [Extract] [Full Text] [PDF]  

Michael Kinter

Toward Broader Inclusion of Liquid Chromatography-Mass Spectrometry in the Clinical Laboratory
Clin Chem 2004 50: 1500-1502. [Extract] [Full Text] [PDF]  

Minireview:

Jens Peter Goetze

Biochemistry of Pro-B-Type Natriuretic Peptide-Derived Peptides: The Endocrine Heart Revisited
Clin Chem 2004 50: 1503-1510. Published online July 20, 2004; 10.1373/clinchem.2004.034272 [Abstract] [Full Text] [PDF]  

Reviews:

Ursula Meier and Axel M. Gressner

Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin
Clin Chem 2004 50: 1511-1525. Published online July 20, 2004; 10.1373/clinchem.2004.032482 [Abstract] [Full Text] [PDF]  

Opinion:

Ralph K. Ito and Laurence M. Demers

Pharmacogenomics and Pharmacogenetics: Future Role of Molecular Diagnostics in the Clinical Diagnostic Laboratory
Clin Chem 2004 50: 1526-1527. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Nicolas von Ahsen, Victor W. Armstrong, and Michael Oellerich

Rapid, Long-Range Molecular Haplotyping of Thiopurine S-Methyltransferase (TPMT*) *3A, *3B, and *3C
Clin Chem 2004 50: 1528-1534. Published online July 9, 2004; 10.1373/clinchem.2004.034751 [Abstract] [Full Text] [PDF] Data Supplement  

Angelito I. Nepomuceno, Christopher J. Mason, David C. Muddiman, H. Robert Bergen, III, and Steven R. Zeldenrust

Detection of Genetic Variants of Transthyretin by Liquid Chromatography–Dual Electrospray Ionization Fourier-Transform Ion-Cyclotron-Resonance Mass Spectrometry
Clin Chem 2004 50: 1535-1543. Published online June 17, 2004; 10.1373/clinchem.2004.033274 [Abstract] [Full Text] [PDF]  

H. Robert Bergen, III, Steven R. Zeldenrust, Malinda L. Butz, Denise S. Snow, Peter J. Dyck, P. James B. Dyck, Christopher J. Klein, John F. O’Brien, Stephen N. Thibodeau, and David C. Muddiman

Identification of Transthyretin Variants by Sequential Proteomic and Genomic Analysis
Clin Chem 2004 50: 1544-1552. Published online June 24, 2004; 10.1373/clinchem.2004.033266 [Abstract] [Full Text] [PDF]  

Lyndsey Birch, Claire A. English, Malcolm Burns, and Jacquie T. Keer

Generic Scheme for Independent Performance Assessment in the Molecular Biology Laboratory
Clin Chem 2004 50: 1553-1559. Published online July 1, 2004; 10.1373/clinchem.2003.029454 [Abstract] [Full Text] [PDF] Data Supplement  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Umed A. Ajani, Earl S. Ford, and Ali H. Mokdad

Prevalence of High C-Reactive Protein in Persons with Serum Lipid Concentrations within Recommended Values
Clin Chem 2004 50: 1618-1622. Published online June 17, 2004; 10.1373/clinchem.2004.036004 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Werner Steimer, Konstanze Zöpf, Silvia von Amelunxen, Herbert Pfeiffer, Julia Bachofer, Johannes Popp, Barbara Messner, Werner Kissling, and Stefan Leucht

Allele-Specific Change of Concentration and Functional Gene Dose for the Prediction of Steady-State Serum Concentrations of Amitriptyline and Nortriptyline in CYP2C19 and CYP2D6 Extensive and Intermediate Metabolizers
Clin Chem 2004 50: 1623-1633. Published online June 17, 2004; 10.1373/clinchem.2003.030825 [Abstract] [Full Text] [PDF]  

Evidence-based Laboratory Medicine and Test Utilization:

Stephanie Lehrke, Henning Steen, Hans H. Sievers, Hanno Peters, Armin Opitz, Margit Müller-Bardorff, Uwe K.H. Wiegand, Hugo A. Katus, and Evangelos Giannitsis

Cardiac Troponin T for Prediction of Short- and Long-Term Morbidity and Mortality after Elective Open Heart Surgery
Clin Chem 2004 50: 1560-1567. Published online June 24, 2004; 10.1373/clinchem.2004.031468 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Maurice M.A.L. Pelsers, Thorsten Hanhoff, Daniëlle Van der Voort, Baer Arts, Maarten Peters, Rudolf Ponds, Adriaan Honig, Wojtek Rudzinski, Friedrich Spener, Jelle R. de Kruijk, Albert Twijnstra, Wim T. Hermens, Paul P.C.A. Menheere, and Jan F.C. Glatz

Brain- and Heart-Type Fatty Acid-Binding Proteins in the Brain: Tissue Distribution and Clinical Utility
Clin Chem 2004 50: 1568-1575. Published online June 24, 2004; 10.1373/clinchem.2003.030361 [Abstract] [Full Text] [PDF]  

Minna Ala-Kopsala, Jarkko Magga, Keijo Peuhkurinen, Jaana Leipälä, Heikki Ruskoaho, Juhani Leppäluoto, and Olli Vuolteenaho

Molecular Heterogeneity Has a Major Impact on the Measurement of Circulating N-Terminal Fragments of A- and B-Type Natriuretic Peptides
Clin Chem 2004 50: 1576-1588. Published online July 20, 2004; 10.1373/clinchem.2004.032490 [Abstract] [Full Text] [PDF]  

Saskia Z.H. Rittersma, Robbert J. de Winter, Karel T. Koch, Carl E. Schotborgh, Matthijs Bax, Gerlind S. Heyde, Jan P. van Straalen, Karla J. Mulder, Jan G.P. Tijssen, Gerard T. Sanders, and Jan J. Piek

Preprocedural C-Reactive Protein Is Not Associated with Angiographic Restenosis or Target Lesion Revascularization after Coronary Artery Stent Placement
Clin Chem 2004 50: 1589-1596. Published online June 17, 2004; 10.1373/clinchem.2004.032656 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Anders Öhrvik, Maria Lindh, Roland Einarsson, Jacques Grassi, and Staffan Eriksson

Sensitive Nonradiometric Method for Determining Thymidine Kinase 1 Activity
Clin Chem 2004 50: 1597-1606. Published online July 9, 2004; 10.1373/clinchem.2003.030379 [Abstract] [Full Text] [PDF]  

Ville Väisänen, Susann Eriksson, Kaisa K. Ivaska, Hans Lilja, Martti Nurmi, and Kim Pettersson

Development of Sensitive Immunoassays for Free and Total Human Glandular Kallikrein 2
Clin Chem 2004 50: 1607-1617. Published online July 9, 2004; 10.1373/clinchem.2004.035253 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Johanna M. Zuetenhorst, Catharina M. Korse, Johannes M.G. Bonfrer, Ellen Peter, Cornelis B.H.W. Lamers, and Babs G. Taal

Daily Cyclic Changes in the Urinary Excretion of 5-Hydroxyindoleacetic Acid in Patients with Carcinoid Tumors
Clin Chem 2004 50: 1634-1639. Published online July 9, 2004; 10.1373/clinchem.2004.032151 [Abstract] [Full Text] [PDF]  

Ann Van Campenhout, Christel Van Campenhout, Albert René Lagrou, and Begoña Manuel-y-Keenoy

Effects of in Vitro Glycation on Fe³⁺ Binding and Fe³⁺ Isoforms of Transferrin
Clin Chem 2004 50: 1640-1649. Published online July 1, 2004; 10.1373/clinchem.2004.033811 [Abstract] [Full Text] [PDF]  

Frank Holger Perschel, Rudolf Schemer, Lysann Seiler, Martin Reincke, Jaap Deinum, Christiane Maser-Gluth, David Mechelhoff, Rudolf Tauber, and Sven Diederich

Rapid Screening Test for Primary Hyperaldosteronism: Ratio of Plasma Aldosterone to Renin Concentration Determined by Fully Automated Chemiluminescence Immunoassays
Clin Chem 2004 50: 1650-1655. Published online July 9, 2004; 10.1373/clinchem.2004.033159 [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Debashis Roy, Juan Quiles, Rajan Sharma, Manas Sinha, Pablo Avanzas, David Gaze, and Juan Carlos Kaski

Ischemia-Modified Albumin Concentrations in Patients with Peripheral Vascular Disease and Exercise-Induced Skeletal Muscle Ischemia
Clin Chem 2004 50: 1656-1660. Published online July 20, 2004; 10.1373/clinchem.2004.031690 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Mar Masiá, Félix Gutiérrez, Belén Llorca, Juan Carlos Navarro, Carlos Mirete, Sergio Padilla, Ildefonso Hernández, and Emilio Flores

Serum Concentrations of Lipopolysaccharide-Binding Protein as a Biochemical Marker to Differentiate Microbial Etiology in Patients with Community-Acquired Pneumonia
Clin Chem 2004 50: 1661-1664. [Extract] [Full Text] [PDF]  

Ad M. Knaapen, Hans B. Ketelslegers, Ralph W.H. Gottschalk, Rob G.J.H. Janssen, Aimee D.C. Paulussen, Hubert J.M. Smeets, Roger W.L. Godschalk, Frederik J. Van Schooten, Jos C.S. Kleinjans, and Joost H.M. Van Delft

Simultaneous Genotyping of Nine Polymorphisms in Xenobiotic-Metabolizing Enzymes by Multiplex PCR Amplification and Single Base Extension
Clin Chem 2004 50: 1664-1668. [Extract] [Full Text] [PDF] Data Supplement  

Johanna Atamaniuk, Claudia Vidotto, Harald Tschan, Norbert Bachl, Karl M. Stuhlmeier, and Mathias M. Müller

Increased Concentrations of Cell-Free Plasma DNA after Exhaustive Exercise
Clin Chem 2004 50: 1668-1670. [Extract] [Full Text] [PDF]  

Hans Kemperman, Mery van den Berg, Hans Kirkels, and Nicolaas de Jonge

B-Type Natriuretic Peptide (BNP) and N-Terminal proBNP in Patients with End-Stage Heart Failure Supported by a Left Ventricular Assist Device
Clin Chem 2004 50: 1670-1672. [Extract] [Full Text] [PDF]  

Su-Hua Huang and Tsung-Chain Chang

Detection of Staphylococcus aureus by a Sensitive Immuno-PCR Assay
Clin Chem 2004 50: 1673-1674. [Extract] [Full Text] [PDF]  

Thomas Marshall and Katherine M. Williams

Elimination of the Interference from Aminoglycoside Antibiotics in the Pyrogallol Red-Molybdate Protein Dye-Binding Assay
Clin Chem 2004 50: 1674-1675. [Extract] [Full Text] [PDF]  

Michael Pullmann, Stefan Hergarten, and Norbert Laube

Influence of a Variable Differential Function on the Stone-Growth-Related Urinary Depletion Effect
Clin Chem 2004 50: 1675-1678. [Extract] [Full Text] [PDF]  

Anders Ståhlberg, Mikael Kubista, and Michael Pfaffl

Comparison of Reverse Transcriptases in Gene Expression Analysis
Clin Chem 2004 50: 1678-1680. [Extract] [Full Text] [PDF] Data Supplement  

Andreas M. Rickert, Hans Lehrach, and Silke Sperling

Multiplexed Real-Time PCR Using Universal Reporters
Clin Chem 2004 50: 1680-1683. [Extract] [Full Text] [PDF] Data Supplement  

Rossa W.K. Chiu, Nelson L.S. Tang, David S.C. Hui, Grace T.Y. Chung, Stephen S.C. Chim, K.C. Allen Chan, Ying-man Sung, Louis Y.S. Chan, Yu-kwan Tong, Wing-shan Lee, Paul K.S. Chan, and Y.M. Dennis Lo

ACE2 Gene Polymorphisms Do Not Affect Outcome of Severe Acute Respiratory Syndrome
Clin Chem 2004 50: 1683-1686. [Extract] [Full Text] [PDF]  

Elena Levtchenko, Adriana de Graaf-Hess, Martijn Wilmer, Lambertus van den Heuvel, Leo Monnens, and Henk Blom

Comparison of Cystine Determination in Mixed Leukocytes vs Polymorphonuclear Leukocytes for Diagnosis of Cystinosis and Monitoring of Cysteamine Therapy
Clin Chem 2004 50: 1686-1688. [Extract] [Full Text] [PDF] Data Supplement  

Jae-Hyun Park, Il-Jin Kim, Hio Chung Kang, Yong Shin, Hye-Won Park, Sang-Geun Jang, Ja-Lok Ku, Seok-Byung Lim, Seung-Yong Jeong, and Jae-Gahb Park

Oligonucleotide Microarray-Based Mutation Detection of the K-ras Gene in Colorectal Cancers with Use of Competitive DNA Hybridization
Clin Chem 2004 50: 1688-1691. [Extract] [Full Text] [PDF]  

Agata Smogorzewska, James G. Flood, William H. Long, and Anand S. Dighe

Paraprotein Interference in Automated Chemistry Analyzers
Clin Chem 2004 50: 1691-1693. [Extract] [Full Text] [PDF]  

Heike Görgens, Guido Fitze, Dietmar Roesner, and Hans K. Schackert

One-Step Analysis of Ten Functional Haplotype Combinations of the Basic RET Promoter with a LightCycler Assay
Clin Chem 2004 50: 1693-1695. Published online July 20, 2004; 10.1373/clinchem.2004.034165 [Extract] [Full Text] [PDF]  

Jiang Li, Shui-Ping Zhao, Dao-quan Peng, Zhu-mei Xu, and Hong-nian Zhou

Early Effect of Pravastatin on Serum Soluble CD40L, Matrix Metalloproteinase-9, and C-Reactive Protein in Patients with Acute Myocardial Infarction
Clin Chem 2004 50: 1696-1699. Published online July 20, 2004; 10.1373/clinchem.2003.030940 [Extract] [Full Text] [PDF] Data Supplement  

Catherine M. Jankowski, Bakary J. Sonko, Wendolyn S. Gozansky, and Wendy M. Kohrt

Deuterium Dilution: The Time Course of ²H Enrichment in Saliva, Urine, and Serum
Clin Chem 2004 50: 1699-1701. [Extract] [Full Text] [PDF] Data Supplement  

Letters to the Editor:

Alexandre Hertig, Nadia Berkane, Guillaume Lefevre, Karine Toumi, Hans-Peter Marti, Jacqueline Capeau, Serge Uzan, and Eric Rondeau

Maternal Serum sFlt1 Concentration Is an Early and Reliable Predictive Marker of Preeclampsia
Clin Chem 2004 50: 1702-1703. [Extract] [Full Text] [PDF]  

Qinghong Han, Xinghua Sun, Mingxu Xu, Nan Zhang, Li Tang, Yuying Tan, and Robert M. Hoffman

3-Deazaadenosine, a Stabilizer of Whole-Blood Homocysteine Content, Does Not Interfere with the Single-Enzyme Homocysteine Assay while Totally Inhibiting the Enzyme Conversion Homocysteine Immunoassay
Clin Chem 2004 50: 1703-1704. [Extract] [Full Text] [PDF]  

Rodney R. Miles, Richard F. Roberts, Angelica R. Putnam, and William L. Roberts

Comparison of Serum and Heparinized Plasma Samples for Measurement of Chemistry Analytes
Clin Chem 2004 50: 1704-1706. [Extract] [Full Text] [PDF] Data Supplement  

Youssef Alj, Edwin Milgrom, and Anne Guiochon-Mantel

Rapid Determination of -Fetoprotein Gene Promoter Mutations in Hereditary Persistence of -Fetoprotein
Clin Chem 2004 50: 1706-1707. [Extract] [Full Text] [PDF]  

Franca Pagani, Francesca Stefini, Gianmatteo Micca, Mario Toppino, Fabio Manoni, Luigi Romano, Paolo Hoffer, Annalisa Iervasi, Marco Caputo, Romolo Dorizzi, Giancarlo Zucchelli, and Mauro Panteghini

Multicenter Evaluation of the TOSOH AIA-Pack Second-Generation Cardiac Troponin I Assay
Clin Chem 2004 50: 1707-1709. [Extract] [Full Text] [PDF]  

Hideaki Masuzaki, Kiyonori Miura, Shoko Miura, Koh-ichiro Yoshiura, Christophe K. Mapendano, Daisuke Nakayama, Shuichiro Yoshimura, Norio Niikawa, and Tadayuki Ishimaru

Labor Increases Maternal DNA Contamination in Cord Blood
Clin Chem 2004 50: 1709-1711. [Extract] [Full Text] [PDF]  

Mauro Panteghini and Franca Pagani

AACC Creatine Kinase MB (CK-MB) Standardization Material Used as Manufacturer’s Working Calibrator Is Unable to Harmonize CK-MB Results between Two Commercial Immunoassays
Clin Chem 2004 50: 1711-1712. [Extract] [Full Text] [PDF]  

Teresa K. Teal, Joanna L. Wood, Paul E. Stevens, and Edmund J. Lamb

Stability of Bio-Intact (1–84) Parathyroid Hormone ex Vivo in Serum and EDTA Plasma from Hemodialysis Patients
Clin Chem 2004 50: 1713-1714. [Extract] [Full Text] [PDF]  

Alex Harrison, Vikas Bhalla, Nancy Gardetto, and Alan S. Maisel

Evolving Use of B-Type Natriuretic Peptide in Clinical Practice
Clin Chem 2004 50: 1714-1715. [Extract] [Full Text] [PDF]  

Ferdinando Mannello, Francesca Luchetti, Barbara Canonico, Elisabetta Falcieri, and Stefano Papa

Measurements, Zymographic Analysis, and Characterization of Matrix Metalloproteinase-2 and -9 in Healthy Human Umbilical Cord Blood
Clin Chem 2004 50: 1715-1717. [Extract] [Full Text] [PDF]  

Katiací Araújo, José da Silva, Adriana Sañudo, and Benjamin Kopelman

Plasma Concentrations of Cardiac Troponin I in Newborn Infants
Clin Chem 2004 50: 1717-1718. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Timothy J. Peters

The Porphyrin Handbook, Volumes 11–20. Karl M. Kadish, Kevin M. Smith, and Roger Guilard, editors. New York: Academic Press, 2003, 3500pp., hardcover, $3500.00. ISBN 0-123-93220-3.
Clin Chem 2004 50: 1719. [Extract] [Full Text] [PDF]  

Anthony A. Killeen

Encyclopedic Dictionary of Genetics, Genomics, and Proteomics, 2nd ed. George P. Rédei. Hoboken, NJ: John Wiley & Sons, Inc., 2003, 1390 pp., $179.00, hardcover. ISBN 0-471-26821-6.
Clin Chem 2004 50: 1719-1720. [Extract] [Full Text] [PDF]  

Pete Kitch

Leonardo’s Laptop: Human Needs and the New Computing Technologies. Ben Shneiderman. 2003, 288 pp., $16.95, paperback. ISBN 0-262-69299-6.
Clin Chem 2004 50: 1720. [Extract] [Full Text] [PDF]  

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