Editorials:

Michael Kleerekoper and Pauline Camacho

Monitoring Osteoporosis Therapy
Clin Chem 2005 51: 2227-2228. [Extract] [Full Text] [PDF]  

Perspectives:

Eva Engvall

Perspective on the Historical Note on EIA/ELISA by Dr. R.M. Lequin
Clin Chem 2005 51: 2225. [Extract] [Full Text] [PDF]  

Bauke K. van Weemen

The Rise of EIA/ELISA
Clin Chem 2005 51: 2226. [Extract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Jinong Li, Rosaria Orlandi, C. Nicole White, Jason Rosenzweig, Jing Zhao, Ettore Seregni, Daniele Morelli, Yinhua Yu, Xiao-Ying Meng, Zhen Zhang, Nancy E. Davidson, Eric T. Fung, and Daniel W. Chan

Independent Validation of Candidate Breast Cancer Serum Biomarkers Identified by Mass Spectrometry
Clin Chem 2005 51: 2229-2235. Published online October 13, 2005; 10.1373/clinchem.2005.052878 [Abstract] [Full Text] [PDF] Data Supplements  

Ann-Joy Cheng, Li-Chiu Chen, Kun-Yi Chien, Yin-Ju Chen, Joseph Tung-Chieh Chang, Hung-Ming Wang, Chun-Ta Liao, and I-How Chen

Oral Cancer Plasma Tumor Marker Identified with Bead-Based Affinity-Fractionated Proteomic Technology
Clin Chem 2005 51: 2236-2244. Published online October 20, 2005; 10.1373/clinchem.2005.052324 [Abstract] [Full Text] [PDF] Data Supplements  

Thomas Mueller, Alfons Gegenhuber, Benjamin Dieplinger, Werner Poelz, and Meinhard Haltmayer

Capability of B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP as Indicators of Cardiac Structural Disease in Asymptomatic Patients with Systemic Arterial Hypertension
Clin Chem 2005 51: 2245-2251. Published online October 13, 2005; 10.1373/clinchem.2005.056648 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Uma Singh, James Tabibian, Senthil K. Venugopal, Sridevi Devaraj, and Ishwarlal Jialal

Development of an In Vitro Screening Assay to Test the Antiinflammatory Properties of Dietary Supplements and Pharmacologic Agents
Clin Chem 2005 51: 2252-2256. Published online September 15, 2005; 10.1373/clinchem.2005.056093 [Abstract] [Full Text] [PDF]  

Byung Jin Kim, Sang Tai Hwang, Ki Chul Sung, Bum Soo Kim, Jin Ho Kang, Man Ho Lee, and Jung Ro Park

Comparison of the Relationships between Serum Apolipoprotein B and Serum Lipid Distributions
Clin Chem 2005 51: 2257-2263. Published online October 7, 2005; 10.1373/clinchem.2005.052738 [Abstract] [Full Text] [PDF]  

Irene Gazi, Evangelia S. Lourida, Theodosios Filippatos, Vasilis Tsimihodimos, Moses Elisaf, and Alexandros D. Tselepis

Lipoprotein-Associated Phospholipase A₂ Activity Is a Marker of Small, Dense LDL Particles in Human Plasma
Clin Chem 2005 51: 2264-2273. Published online October 13, 2005; 10.1373/clinchem.2005.058404 [Abstract] [Full Text] [PDF] Data Supplements  

Drug Monitoring and Toxicology:

Jun Peng, Rupasri Mandal, Michael Sawyer, and Xing-Fang Li

Characterization of Intact Hemoglobin and Oxaliplatin Interaction by Nanoelectrospray Ionization Tandem Mass Spectrometry
Clin Chem 2005 51: 2274-2281. Published online September 29, 2005; 10.1373/clinchem.2005.051847 [Abstract] [Full Text] [PDF] Data Supplements  

Nicolas von Ahsen, Victor W. Armstrong, Christoph Behrens, Christian von Tirpitz, Andreas Stallmach, Hans Herfarth, Jürgen Stein, Peter Bias, Guido Adler, Maria Shipkova, Michael Oellerich, Wolfgang Kruis, and Max Reinshagen

Association of Inosine Triphosphatase 94C>A and Thiopurine S-Methyltransferase Deficiency with Adverse Events and Study Drop-Outs under Azathioprine Therapy in a Prospective Crohn Disease Study
Clin Chem 2005 51: 2282-2288. Published online October 7, 2005; 10.1373/clinchem.2005.057158 [Abstract] [Full Text] [PDF]  

Marilyn A. Huestis, Allan Barnes, and Michael L. Smith

Estimating the Time of Last Cannabis Use from Plasma ⁹-Tetrahydrocannabinol and 11-nor-9-Carboxy-⁹-Tetrahydrocannabinol Concentrations
Clin Chem 2005 51: 2289-2295. Published online October 13, 2005; 10.1373/clinchem.2005.056838 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Karen G. Halse, Marie L.S. Lindegaard, Jens P. Goetze, Peter Damm, Elisabeth R. Mathiesen, and Lars B. Nielsen

Increased Plasma Pro-B-Type Natriuretic Peptide in Infants of Women with Type 1 Diabetes
Clin Chem 2005 51: 2296-2302. Published online September 22, 2005; 10.1373/clinchem.2005.056077 [Abstract] [Full Text] [PDF]  

Linda M. Thienpont, Katleen Van Uytfanghe, John Marriott, Peter Stokes, Lothar Siekmann, Anja Kessler, David Bunk, and Susan Tai

Feasibility Study of the Use of Frozen Human Sera in Split-Sample Comparison of Immunoassays with Candidate Reference Measurement Procedures for Total Thyroxine and Total Triiodothyronine Measurements
Clin Chem 2005 51: 2303-2311. Published online October 13, 2005; 10.1373/clinchem.2005.058180 [Abstract] [Full Text] [PDF] Data Supplement  

Yoshifumi Maeno, Masaaki Inaba, Senji Okuno, Tomoyuki Yamakawa, Eiji Ishimura, and Yoshiki Nishizawa

Serum Concentrations of Cross-Linked N-Telopeptides of Type I Collagen: New Marker for Bone Resorption in Hemodialysis Patients
Clin Chem 2005 51: 2312-2317. Published online October 13, 2005; 10.1373/clinchem.2005.051524 [Abstract] [Full Text] [PDF] Data Supplements  

General Clinical Chemistry:

Zia Fazili, Christine M. Pfeiffer, Ming Zhang, and Ram Jain

Erythrocyte Folate Extraction and Quantitative Determination by Liquid Chromatography–Tandem Mass Spectrometry: Comparison of Results with Microbiologic Assay
Clin Chem 2005 51: 2318-2325. Published online October 7, 2005; 10.1373/clinchem.2005.053801 [Abstract] [Full Text] [PDF] Data Supplements  

Helge Erik Solberg and Ari Lahti

Detection of Outliers in Reference Distributions: Performance of Horn’s Algorithm
Clin Chem 2005 51: 2326-2332. Published online October 13, 2005; 10.1373/clinchem.2005.058339 [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Nelson Leung-Sang Tang, Paul Kay-Sheung Chan, Chun-Kwok Wong, Ka-Fai To, Alan Ka-Lun Wu, Ying-Man Sung, David Shu-Cheong Hui, Joseph Jao-Yiu Sung, and Christopher Wai-Kei Lam

Early Enhanced Expression of Interferon-Inducible Protein-10 (CXCL-10) and Other Chemokines Predicts Adverse Outcome in Severe Acute Respiratory Syndrome
Clin Chem 2005 51: 2333-2340. Published online September 29, 2005; 10.1373/clinchem.2005.054460 [Abstract] [Full Text] [PDF]  

Wolf-Dietrich Döcke, Conny Höflich, Kenneth A. Davis, Karsten Röttgers, Christian Meisel, Paul Kiefer, Stefan U. Weber, Monika Hedwig-Geissing, Ernst Kreuzfelder, Peter Tschentscher, Thomas Nebe, Andrea Engel, Guillaume Monneret, Andreas Spittler, Kathrin Schmolke, Petra Reinke, Hans-Dieter Volk, and Dagmar Kunz

Monitoring Temporary Immunodepression by Flow Cytometric Measurement of Monocytic HLA-DR Expression: A Multicenter Standardized Study
Clin Chem 2005 51: 2341-2347. Published online October 7, 2005; 10.1373/clinchem.2005.052639 [Abstract] [Full Text] [PDF] Data Supplements  

Other Areas of Clinical Chemistry:

Markus Herrmann, Thomas Widmann, Graziana Colaianni, Silvia Colucci, Alberta Zallone, and Wolfgang Herrmann

Increased Osteoclast Activity in the Presence of Increased Homocysteine Concentrations
Clin Chem 2005 51: 2348-2353. Published online September 29, 2005; 10.1373/clinchem.2005.053363 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Wenli Zhou, Ronald V. Abruzzese, Irina Polejaeva, Sara Davis, Scott Davis, and Wan Ji

Amplification of Nanogram Amounts of Total RNA by the SMART-Based PCR Method for High-Density Oligonucleotide Microarrays
Clin Chem 2005 51: 2354-2356. [Extract] [Full Text] [PDF] Data Supplements  

Michele Falco, Corrado Romano, Antonino Alberti, Donatella Greco, Carmela Scuderi, Emanuela Avola, Pinella Failla, Serena Belli, John L. Tolmie, Silvestra Amata, and Marco Fichera

Identification of Novel Mutations in Patients with Coffin–Lowry Syndrome by a Denaturing HPLC-Based Assay
Clin Chem 2005 51: 2356-2358. [Extract] [Full Text] [PDF]  

Nancy B.Y. Tsui, Rossa W.K. Chiu, Chunming Ding, Ahmad El-Sheikhah, Tse N. Leung, Tze K. Lau, Kypros H. Nicolaides, and Y.M. Dennis Lo

Detection of Trisomy 21 by Quantitative Mass Spectrometric Analysis of Single-Nucleotide Polymorphisms
Clin Chem 2005 51: 2358-2362. [Extract] [Full Text] [PDF] Data Supplements  

Kaisa K. Ivaska, Kim Pettersson, Arja Nenonen, Kirsti Uusi-Rasi, Ari Heinonen, Pekka Kannus, and H. Kalervo Väänänen

Urinary Osteocalcin Is a Useful Marker for Monitoring the Effect of Alendronate Therapy
Clin Chem 2005 51: 2362-2365. [Extract] [Full Text] [PDF]  

Robert Zimmermann, Julia Koenig, Juergen Zingsem, Volker Weisbach, Erwin Strasser, Juergen Ringwald, and Reinhold Eckstein

Effect of Specimen Anticoagulation on the Measurement of Circulating Platelet-Derived Growth Factors
Clin Chem 2005 51: 2365-2368. [Extract] [Full Text] [PDF]  

Federica Bortolotti, Giorgia De Paoli, Jennifer P. Pascali, Maria T. Trevisan, Mirella Floreani, and Franco Tagliaro

Analysis of Carbohydrate-Deficient Transferrin: Comparative Evaluation of Turbidimetric Immunoassay, Capillary Zone Electrophoresis, and HPLC
Clin Chem 2005 51: 2368-2371. [Extract] [Full Text] [PDF]  

Monica Arenas, Gemma Simpson, Cathryn M. Lewis, El-Monsor Shobowale-Bakre, Emilia Escuredo, Lynette D. Fairbanks, John A. Duley, Azhar Ansari, Jeremy D. Sanderson, and Anthony M. Marinaki

Genetic Variation in the MTHFR Gene Influences Thiopurine Methyltransferase Activity
Clin Chem 2005 51: 2371-2374. [Extract] [Full Text] [PDF]  

Camille Brasselet, Roselyne Garnotel, Antoine Lafont, Sophie Perotin, Fabien Vitry, Eric Durand, Laurent Ducher, Jacques Elaerts, Damien Metz, and Philippe Gillery

Prepercutaneous Coronary Intervention Plasma Homocysteine Concentration Is a Useful Predictor of Angioplasty-Induced Myocardial Damage
Clin Chem 2005 51: 2374-2377. [Extract] [Full Text] [PDF]  

Paula M. Ladwig, Robert R. Liedtke, Timothy S. Larson, and John C. Lieske

Sensitive Spectrophotometric Assay for Plasma Oxalate
Clin Chem 2005 51: 2377-2380. [Extract] [Full Text] [PDF] Data Supplement  

Andrew J. Duncan, Simon J.R. Heales, Kevin Mills, Simon Eaton, John M. Land, and Iain P. Hargreaves

Determination of Coenzyme Q₁₀ Status in Blood Mononuclear Cells, Skeletal Muscle, and Plasma by HPLC with Di-Propoxy-Coenzyme Q₁₀ as an Internal Standard
Clin Chem 2005 51: 2380-2382. [Extract] [Full Text] [PDF] Data Supplements  

Matti J. Välimäki and Riitta Tähtelä

Serum Tartrate-Resistant Acid Phosphatase 5b or Amino-Terminal Propeptide of Type I Procollagen for Monitoring Bisphosphonate Therapy in Postmenopausal Osteoporosis?
Clin Chem 2005 51: 2382-2385. [Extract] [Full Text] [PDF]  

John F. Wilson and Kathleen Barnett

Variation with Time in Components of Variance for Measurements of Therapeutic Drugs
Clin Chem 2005 51: 2385-2387. [Extract] [Full Text] [PDF] Data Supplements  

Max Käller, Rainer Tuominen, Afshin Ahmadian, Veronica Magnusson, Suzanne Egyhazi, Johan Hansson, and Joakim Lundeberg

Detection of MC1R Polymorphisms with Protease-Mediated Allele-Specific Extension as an Alternative to Direct Sequencing
Clin Chem 2005 51: 2388-2391. [Extract] [Full Text] [PDF] Data Supplement  

Nicolaos Christodoulides, Pierre N. Floriano, Shelley A. Acosta, Karri L. Michael Ballard, Shannon E. Weigum, Sanghamitra Mohanty, Priya Dharshan, Dwight Romanovicz, and John T. McDevitt

Toward the Development of a Lab-on-a-Chip Dual-Function Leukocyte and C-Reactive Protein Analysis Method for the Assessment of Inflammation and Cardiac Risk
Clin Chem 2005 51: 2391-2395. [Extract] [Full Text] [PDF]  

Leonid M. Irenge, Annie Robert, and Jean-Luc Gala

Quantitative Assessment of Human ß-Globin Gene Expression In Vitro by TaqMan Real-Time Reverse Transcription-PCR: Comparison with Competitive Reverse Transcription-PCR and Application to Mutations or Deletions in Noncoding Regions
Clin Chem 2005 51: 2395-2396. [Extract] [Full Text] [PDF]  

Sohji Nagase, Aki Hirayama, Atsushi Ueda, Takaaki Oteki, Kenji Takada, Mariko Inoue, Yukari Shimozawa, Junji Terao, and Akio Koyama

Light-Shielded Hemodialysis Prevents Hypotension and Lipid Peroxidation by Inhibiting Nitric Oxide Production
Clin Chem 2005 51: 2397-2398. [Extract] [Full Text] [PDF]  

K.C. Allen Chan, Angela B.Y. Hui, Nathalie Wong, Tze K. Lau, Tse N. Leung, Kwok-Wai Lo, and Y.M. Dennis Lo

Investigation of the Genomic Representation of Plasma DNA in Pregnant Women by Comparative Genomic Hybridization Analysis: A Feasibility Study
Clin Chem 2005 51: 2398-2401. [Extract] [Full Text] [PDF]  

Laszlo Góth, Zoltán Tóth, Ildikó Tarnai, Maria Bérces, Peter Török, and William N. Bigler

Blood Catalase Activity in Gestational Diabetes Is Decreased but Not Associated with Pregnancy Complications
Clin Chem 2005 51: 2401-2404. [Extract] [Full Text] [PDF]  

Christoph Koidl, Michael Bozic, Jörg Berg, Markus Stöcher, Gerhard Mühlbauer, Egon Marth, and Harald H. Kessler

Addition of a Homologous Internal Control to a Real-Time PCR Assay for Detection of Bordetella pertussis
Clin Chem 2005 51: 2404-2406. [Extract] [Full Text] [PDF]  

Narayan Torke, Leonard Boral, Tracy Nguyen, Angelo Perri, and Alan Chakrin

Process Improvement and Operational Efficiency through Test Result Autoverification
Clin Chem 2005 51: 2406-2408. [Extract] [Full Text] [PDF]  

Peter Findeisen, Diamandula Sismanidis, Martin Riedl, Victor Costina, and Michael Neumaier

Preanalytical Impact of Sample Handling on Proteome Profiling Experiments with Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Clin Chem 2005 51: 2409-2411. [Extract] [Full Text] [PDF] Data Supplements  

GianCarla Gerli, Chiara Vanelli, Olivia Turri, Maddalena Erario, Angelo Gardellini, Mariateresa Pugliano, and Maria Luisa Biondi

SDF1-3'A Gene Polymorphism Is Associated with Chronic Myeloproliferative Disease and Thrombotic Events
Clin Chem 2005 51: 2411-2414. [Extract] [Full Text] [PDF]  

History:

Rudolf M. Lequin

Enzyme Immunoassay (EIA)/Enzyme-Linked Immunosorbent Assay (ELISA)
Clin Chem 2005 51: 2415-2418. Published online September 22, 2005; 10.1373/clinchem.2005.051532 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Dorothy J. Huang, Bernhard G. Zimmermann, Wolfgang Holzgreve, and Sinuhe Hahn

Use of an Automated Method Improves the Yield and Quality of Cell-Free Fetal DNA Extracted from Maternal Plasma
Clin Chem 2005 51: 2419-2420. [Extract] [Full Text] [PDF]  

Nathalie Zammatteo, Caroline Davril, Francis Brasseur, Sandrine Hamels, Etienne De Plaen, Thierry Boon, and José Remacle

Unambiguous Identification of the Expressed MAGE-A Genes on a DNA Microarray
Clin Chem 2005 51: 2420-2421. [Extract] [Full Text] [PDF] Data Supplements  

Larry J. Kricka, Jason Y. Park, Marilyn B. Senior, and Rodelia Fontanilla

Processing Controls in Blood Collection Tubes Reveals Interference
Clin Chem 2005 51: 2422-2423. [Extract] [Full Text] [PDF]  

Swati Bhat, Emma L. Williams, and Gill Rumsby

Tissue Differences in the Expression of Mutations and Polymorphisms in the GRHPR Gene and Implications for Diagnosis of Primary Hyperoxaluria Type 2
Clin Chem 2005 51: 2423-2425. [Extract] [Full Text] [PDF]  

Goce Dimeski, Peter Mollee, and Andrew Carter

Increased Lipid Concentration Is Associated with Increased Hemolysis
Clin Chem 2005 51: 2425. [Extract] [Full Text] [PDF]  

Xavier Bossuyt and Ariane Luyckx

Antibodies to Extractable Nuclear Antigens in Antinuclear Antibody–Negative Samples
Clin Chem 2005 51: 2426-2427. [Extract] [Full Text] [PDF]  

Book, Software, and Website Reviews:

Michael A. Noble

Bacteria in Biology, Biotechnology and Medicine, 6th ed. Paul Singleton. West Sussex, England: John Wiley & Sons Ltd., 2004, 570 pp., $80.00, paperback. ISBN 0-470-09027-8.
Clin Chem 2005 51: 2428. [Extract] [Full Text] [PDF]  

Glen L. Hortin

The Inside Story: DNA to RNA to Protein. Jan Witkowski, editor. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2005, 382 pp., $29.00, paperback. ISBN 0-87969-750-4.
Clin Chem 2005 51: 2428-2429. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Larry J. Kricka, Peter Wilding Compiled by David E. Bruns, Editor

Clin Chem 2005 51: 2430-2431. [Extract] [Full Text] [PDF]  

Compiled by David E. Bruns, Editor

Clin Chem 2005 51: 2431-2432. [Extract] [Full Text] [PDF]  

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