Editorials:

Bradley B. Miller and James W. Mandell

Multiplex Method for Measuring Biomarkers of Alzheimer Disease in Cerebrospinal Fluid
Clin Chem 2005 51: 289-290. [Extract] [Full Text] [PDF]  

Willem G. Zijlstra

Clinical Assessment of Oxygen Transport-Related Quantities
Clin Chem 2005 51: 291-292. [Extract] [Full Text] [PDF]  

Gary Curhan

Cystatin C: A Marker of Renal Function or Something More?
Clin Chem 2005 51: 293-294. [Extract] [Full Text] [PDF]  

Valentine Charlton-Menys and Paul N. Durrington

Apolipoprotein A5 and Hypertriglyceridemia
Clin Chem 2005 51: 295-297. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Siegfried Kösel, Siegfried Burggraf, Ralph Fingerhut, Helmut G. Dörr, Adelbert A. Roscher, and Bernhard Olgemöller

Rapid Second-Tier Molecular Genetic Analysis for Congenital Adrenal Hyperplasia Attributable to Steroid 21-Hydroxylase Deficiency
Clin Chem 2005 51: 298-304. Published online December 17, 2004; 10.1373/clinchem.2004.042416 [Abstract] [Full Text] [PDF]  

Willie Girald-Rosa, Ruth A. Vleugels, Amy C. Musiek, and James E. Sligh

High-Throughput Mitochondrial Genome Screening Method for Nonmelanoma Skin Cancer Using Multiplexed Temperature Gradient Capillary Electrophoresis
Clin Chem 2005 51: 305-311. Published online December 8, 2004; 10.1373/clinchem.2004.040311 [Abstract] [Full Text] [PDF] Data Supplements  

Lyndsey Birch, Claire A. English, Keelin O’Donoghue, Olivia Barigye, Nicholas M. Fisk, and Jacquie T. Keer

Accurate and Robust Quantification of Circulating Fetal and Total DNA in Maternal Plasma from 5 to 41 Weeks of Gestation
Clin Chem 2005 51: 312-320. Published online December 17, 2004; 10.1373/clinchem.2004.042713 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Wolfgang Koenig, Dorothee Twardella, Hermann Brenner, and Dietrich Rothenbacher

Plasma Concentrations of Cystatin C in Patients with Coronary Heart Disease and Risk for Secondary Cardiovascular Events: More than Simply a Marker of Glomerular Filtration Rate
Clin Chem 2005 51: 321-327. Published online November 24, 2004; 10.1373/clinchem.2004.041889 [Abstract] [Full Text] [PDF]  

Terence C.W. Poon, Alex Y. Hui, Henry L.Y. Chan, Irene Ling Ang, Shuk Man Chow, Nathalie Wong, and Joseph J.Y. Sung

Prediction of Liver Fibrosis and Cirrhosis in Chronic Hepatitis B Infection by Serum Proteomic Fingerprinting: A Pilot Study
Clin Chem 2005 51: 328-335. Published online December 8, 2004; 10.1373/clinchem.2004.041764 [Abstract] [Full Text] [PDF]  

Annika Olsson, Hugo Vanderstichele, Niels Andreasen, Geert De Meyer, Anders Wallin, Björn Holmberg, Lars Rosengren, Eugeen Vanmechelen, and Kaj Blennow

Simultaneous Measurement of ß-Amyloid_(1–42), Total Tau, and Phosphorylated Tau (Thr¹⁸¹) in Cerebrospinal Fluid by the xMAP Technology
Clin Chem 2005 51: 336-345. Published online November 24, 2004; 10.1373/clinchem.2004.039347 [Abstract] [Full Text] [PDF] Data Supplement  

Cancer Diagnostics:

Qing-Bo Li, Xue-Jun Sun, Yi-Zhuang Xu, Li-Min Yang, Yuan-Fu Zhang, Shi-Fu Weng, Jing-Sen Shi, and Jin-Guang Wu

Diagnosis of Gastric Inflammation and Malignancy in Endoscopic Biopsies Based on Fourier Transform Infrared Spectroscopy
Clin Chem 2005 51: 346-350. Published online January 6, 2005; 10.1373/clinchem.2004.037986 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Peter J. O’Brien, William E. Alborn, John H. Sloan, Maverick Ulmer, Amechand Boodhoo, Michael D. Knierman, Albert E. Schultze, and Robert J. Konrad

The Novel Apolipoprotein A5 Is Present in Human Serum, Is Associated with VLDL, HDL, and Chylomicrons, and Circulates at Very Low Concentrations Compared with Other Apolipoproteins
Clin Chem 2005 51: 351-359. Published online November 4, 2004; 10.1373/clinchem.2004.040824 [Abstract] [Full Text] [PDF]  

Oliviero Olivieri, Nicola Martinelli, Marco Sandri, Antonella Bassi, Patrizia Guarini, Elisabetta Trabetti, Francesca Pizzolo, Domenico Girelli, Simonetta Friso, Pier Franco Pignatti, and Roberto Corrocher

Apolipoprotein C-III, n-3 Polyunsaturated Fatty Acids, and "Insulin-Resistant" T–455C APOC3 Gene Polymorphism in Heart Disease Patients: Example of Gene-Diet Interaction
Clin Chem 2005 51: 360-367. Published online December 2, 2004; 10.1373/clinchem.2004.040477 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Hongwu Du, Moutian Wu, Weiping Yang, Gu Yuan, Yimin Sun, Yuan Lu, Shan Zhao, Qingyun Du, Jun Wang, Sheng Yang, Mangen Pan, Ying Lu, Shan Wang, and Jing Cheng

Development of Miniaturized Competitive Immunoassays on a Protein Chip as a Screening Tool for Drugs
Clin Chem 2005 51: 368-375. Published online November 24, 2004; 10.1373/clinchem.2004.036665 [Abstract] [Full Text] [PDF] Data Supplement  

Werner Steimer, Konstanze Zöpf, Silvia von Amelunxen, Herbert Pfeiffer, Julia Bachofer, Johannes Popp, Barbara Messner, Werner Kissling, and Stefan Leucht

Amitriptyline or Not, That Is the Question: Pharmacogenetic Testing of CYP2D6 and CYP2C19 Identifies Patients with Low or High Risk for Side Effects in Amitriptyline Therapy
Clin Chem 2005 51: 376-385. Published online December 8, 2004; 10.1373/clinchem.2004.041327 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Gary L. Schwartz and Stephen T. Turner

Screening for Primary Aldosteronism in Essential Hypertension: Diagnostic Accuracy of the Ratio of Plasma Aldosterone Concentration to Plasma Renin Activity
Clin Chem 2005 51: 386-394. [Abstract] [Full Text] [PDF]  

Jean-Claude Souberbielle, Véronique Fayol, Corinne Sault, Ethel Lawson-Body, André Kahan, and Catherine Cormier

Assay-Specific Decision Limits for Two New Automated Parathyroid Hormone and 25-Hydroxyvitamin D Assays
Clin Chem 2005 51: 395-400. Published online November 24, 2004; 10.1373/clinchem.2004.037606 [Abstract] [Full Text] [PDF]  

Markus Thaler, Jochen Metzger, Anita Schreiegg, Barbara Denk, Andreas Gleixner, Hagen Hauptmann, and Peter B. Luppa

Immunoassay for Sex Hormone-Binding Globulin in Undiluted Serum Is Influenced by High-Molecular-Mass Aggregates
Clin Chem 2005 51: 401-407. Published online December 8, 2004; 10.1373/clinchem.2004.034264 [Abstract] [Full Text] [PDF] Data Supplements  

Grazyna Chwatko and Hieronim Jakubowski

Urinary Excretion of Homocysteine-Thiolactone in Humans
Clin Chem 2005 51: 408-415. Published online December 2, 2004; 10.1373/clinchem.2004.042531 [Abstract] [Full Text] [PDF]  

Nectaria Xita, Ioannis Georgiou, Anthoula Chatzikyriakidou, Maria Vounatsou, Gerasimos-Peter Papassotiriou, Ioannis Papassotiriou, and Agathocles Tsatsoulis

Effect of Adiponectin Gene Polymorphisms on Circulating Adiponectin and Insulin Resistance Indexes in Women with Polycystic Ovary Syndrome
Clin Chem 2005 51: 416-423. Published online December 8, 2004; 10.1373/clinchem.2004.043109 [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Raffick A.R. Bowen, Yung Chan, Joshua Cohen, Nadja N. Rehak, Glen L. Hortin, Gyorgy Csako, and Alan T. Remaley

Effect of Blood Collection Tubes on Total Triiodothyronine and Other Laboratory Assays
Clin Chem 2005 51: 424-433. Published online December 2, 2004; 10.1373/clinchem.2004.043349 [Abstract] [Full Text] [PDF] Data Supplement  

Case Conference:

Shannon Haymond, Rohit Cariappa, Charles S. Eby, and Mitchell G. Scott

Laboratory Assessment of Oxygenation in Methemoglobinemia
Clin Chem 2005 51: 434-444. Published online October 28, 2004; 10.1373/clinchem.2004.035154 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Aldo Clerico, Concetta Prontera, Michele Emdin, Claudio Passino, Simona Storti, Roberta Poletti, Luc Zyw, and Gian Carlo Zucchelli

Analytical Performance and Diagnostic Accuracy of Immunometric Assays for the Measurement of Plasma B-Type Natriuretic Peptide (BNP) and N-Terminal proBNP
Clin Chem 2005 51: 445-447. [Extract] [Full Text] [PDF] Data Supplement  

Svetlana Dubiley, Angelina Mayorova, Anna Ignatova, Eugene Kirillov, Valentina Stepanshina, Alexander Kolesnikov, and Igor Shemyakin

New PCR-Based Assay for Detection of Common Mutations Associated with Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis
Clin Chem 2005 51: 447-450. [Extract] [Full Text] [PDF] Data Supplement  

David A. Lacher, Jeffery P. Hughes, and Margaret D. Carroll

Estimate of Biological Variation of Laboratory Analytes Based on the Third National Health and Nutrition Examination Survey
Clin Chem 2005 51: 450-452. Published online December 8, 2004; 10.1373/clinchem.2004.039354 [Extract] [Full Text] [PDF]  

Giorgio Ghilardi, Maria Luisa Biondi, Anna La Torre, Lodovica Battaglioli, and Roberto Scorza

Breast Cancer Progression and Host Polymorphisms in the Chemokine System: Role of the Macrophage Chemoattractant Protein-1 (MCP-1) –2518 G Allele
Clin Chem 2005 51: 452-455. [Extract] [Full Text] [PDF] Data Supplement  

Sarah L. Molyneux, Christopher M. Florkowski, Michael Lever, and Peter M. George

Biological Variation of Coenzyme Q₁₀
Clin Chem 2005 51: 455-457. [Extract] [Full Text] [PDF]  

Thomas M. Annesley

Application of Commercial Calibrators for the Analysis of Immunosuppressant Drugs in Whole Blood
Clin Chem 2005 51: 457-460. Published online November 24, 2004; 10.1373/clinchem.2004.043992 [Extract] [Full Text] [PDF] Data Supplement  

Fred S. Apple and MaryAnn M. Murakami

Cardiac Troponin and Creatine Kinase MB Monitoring during In-Hospital Myocardial Reinfarction
Clin Chem 2005 51: 460-463. Published online November 24, 2004; 10.1373/clinchem.2004.042887 [Extract] [Full Text] [PDF]  

Case Reports:

Christine Papadea and Rodney J. Schlosser

Rapid Method for ß₂-Transferrin in Cerebrospinal Fluid Leakage Using an Automated Immunofixation Electrophoresis System
Clin Chem 2005 51: 464-470. Published online December 17, 2004; 10.1373/clinchem.2004.042697 [Abstract] [Full Text] [PDF] Data Supplement  

Letters to the Editor:

Jørgen Hilden and Nancy Obuchowski

What Properties Should an Overall Measure of Test Performance Possess? • Dr. Obuchowski responds:
Clin Chem 2005 51: 471-472. [Extract] [Full Text] [PDF]  

Ravinder J. Singh, Stefan K. Grebe, Bingfang Yue, Alan L. Rockwood, John C. Cramer, Zoltan Gombos, Graeme Eisenhofer, and Steven Binder

Precisely Wrong? Urinary Fractionated Metanephrines and Peer-Based Laboratory Proficiency Testing • A representative for Bio-Rad responds:
Clin Chem 2005 51: 472-474. [Extract] [Full Text] [PDF]  

Paul N. Span, Nicolai I. Grebenchtchikov, Anneke Geurts-Moespot, and Fred C.G.J. Sweep

Concerns about Mammaglobin Assays
Clin Chem 2005 51: 474-475. [Extract] [Full Text] [PDF]  

Albert Wolthuis and Jan de Vreeze

Unexpected Testosterone Result for External Quality Assessment Scheme Sample
Clin Chem 2005 51: 475-476. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

D. Robert Dufour

Hepatitis B and D Protocols–Volume I: Detection, Genotypes, and Characterization. Robert K. Hamatake and Johnson Y.N. Lau, editors. Totowa, NJ: Humana Press, 2004, 374 pp., $125.00, hardcover. ISBN 1-58829-105-7.
Clin Chem 2005 51: 477. [Extract] [Full Text] [PDF]  

D. Robert Dufour

Hepatitis B and D Protocols–Volume II: Immunology, Model Systems, and Clinical Studies. Robert K. Hamatake and Johnson Y.N. Lau, editors. Totowa, NJ: Humana Press, 2004, 596 pp., $135.00, hardcover. ISBN 1-58829-108-1.
Clin Chem 2005 51: 477-478. [Extract] [Full Text] [PDF]  

Corrections:

Correction for Volume 50, Issue , p. 1074
Clin Chem 2005 51: 480. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

David E. Bruns

The Clinical Chemist
Clin Chem 2005 51: 479-480. [Extract] [Full Text] [PDF]  

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