Editorials:

Lawrence M. Silverman and Theodore M. Mifflin

Genotype–Phenotype Correlations (II): Assessing the Influence of Sequence Variants on the Clinical Phenotype in Multifactorial Disorders
Clin Chem 2005 51: 929-930. [Extract] [Full Text] [PDF]  

Review:

Gerald M. Reaven

The Metabolic Syndrome: Requiescat in Pace
Clin Chem 2005 51: 931-938. Published online March 3, 2005; 10.1373/clinchem.2005.048611 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

María C. Ledesma and José A.G. Agúndez

Identification of Subtypes of CYP2D Gene Rearrangements among Carriers of CYP2D6 Gene Deletion and Duplication
Clin Chem 2005 51: 939-943. Published online April 7, 2005; 10.1373/clinchem.2004.046326 [Abstract] [Full Text] [PDF] Data Supplement  

Sergio Bernardini, Lorenza Bellincampi, Sabrina Ballerini, Giorgio Federici, Roberta Iori, Alberto Trequattrini, Fabrizio Ciappi, Francesca Baldinetti, Paola Bossù, Carlo Caltagirone, and Gianfranco Spalletta

Glutathione S-Transferase P1 *C Allelic Variant Increases Susceptibility for Late-Onset Alzheimer Disease: Association Study and Relationship with Apolipoprotein E 4 Allele
Clin Chem 2005 51: 944-951. Published online April 1, 2005; 10.1373/clinchem.2004.045955 [Abstract] [Full Text] [PDF]  

Kety Hsieh, Wolfgang Lalouschek, Martin Schillinger, Georg Endler, Manuela Reisinger, Michael Janisiw, Wilfried Lang, Suzanne Cheng, Oswald Wagner, and Christine Mannhalter

Impact of ENaC Polymorphisms on the Risk of Ischemic Cerebrovascular Events: A Multicenter Case–Control Study
Clin Chem 2005 51: 952-956. Published online February 25, 2005; 10.1373/clinchem.2004.046276 [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Jörg Geiger, Lino Teichmann, Ralf Grossmann, Barsom Aktas, Udo Steigerwald, Ulrich Walter, and Reinhard Schinzel

Monitoring of Clopidogrel Action: Comparison of Methods
Clin Chem 2005 51: 957-965. Published online April 7, 2005; 10.1373/clinchem.2004.047050 [Abstract] [Full Text] [PDF] Data Supplements  

Proteomics and Protein Markers:

Jeremy A. Simpson, Ralf Labugger, Christine Collier, Robert J. Brison, Steve Iscoe, and Jennifer E. Van Eyk

Fast and Slow Skeletal Troponin I in Serum from Patients with Various Skeletal Muscle Disorders: A Pilot Study
Clin Chem 2005 51: 966-972. Published online April 15, 2005; 10.1373/clinchem.2004.042671 [Abstract] [Full Text] [PDF]  

Sven Baumann, Uta Ceglarek, Georg Martin Fiedler, Jan Lembcke, Alexander Leichtle, and Joachim Thiery

Standardized Approach to Proteome Profiling of Human Serum Based on Magnetic Bead Separation and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Clin Chem 2005 51: 973-980. Published online April 21, 2005; 10.1373/clinchem.2004.047308 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Kazuo Koyanagi, Christine Kuo, Taku Nakagawa, Takuji Mori, Hideaki Ueno, Arnulfo R. Lorico, Jr, He-Jing Wang, Eddie Hseuh, Steven J. O’Day, and Dave S.B. Hoon

Multimarker Quantitative Real-Time PCR Detection of Circulating Melanoma Cells in Peripheral Blood: Relation to Disease Stage in Melanoma Patients
Clin Chem 2005 51: 981-988. Published online April 7, 2005; 10.1373/clinchem.2004.045096 [Abstract] [Full Text] [PDF] Data Supplements  

Hematology:

Karin Zurbriggen, Markus Schmugge, Marlis Schmid, Silke Durka, Peter Kleinert, Thomas Kuster, Claus W. Heizmann, and Heinz Troxler

Analysis of Minor Hemoglobins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Clin Chem 2005 51: 989-996. Published online April 7, 2005; 10.1373/clinchem.2005.047985 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Michael Gröschl, Hans G. Topf, Jörg Bohlender, Johannes Zenk, Sven Klussmann, Jörg Dötsch, Wolfgang Rascher, and Manfred Rauh

Identification of Ghrelin in Human Saliva: Production by the Salivary Glands and Potential Role in Proliferation of Oral Keratinocytes
Clin Chem 2005 51: 997-1006. Published online March 24, 2005; 10.1373/clinchem.2004.040667 [Abstract] [Full Text] [PDF] Data Supplements  

Automation and Analytical Techniques:

Emilia Bramanti, Cecilia Vecoli, Danilo Neglia, Maria Paola Pellegrini, Giorgio Raspi, and Renata Barsacchi

Speciation and Quantification of Thiols by Reversed-Phase Chromatography Coupled with On-Line Chemical Vapor Generation and Atomic Fluorescence Spectrometric Detection: Method Validation and Preliminary Application for Glutathione Measurements in Human Whole Blood
Clin Chem 2005 51: 1007-1013. Published online April 21, 2005; 10.1373/clinchem.2004.045443 [Abstract] [Full Text] [PDF] Data Supplements  

Technical Briefs:

Eloy Fernández, Carlos Blanco, Sara García, Angeles Dieguez, Sabino Riestra, and Luis Rodrigo

Use of Low Concentrations of Human IgA Anti-Tissue Transglutaminase to Rule Out Selective IgA Deficiency in Patients with Suspected Celiac Disease,
Clin Chem 2005 51: 1014-1016. Published online March 24, 2005; 10.1373/clinchem.2004.047233 [Extract] [Full Text] [PDF]  

Anna Lis Lauridsen, Michael Aarup, Anna Lisa Christensen, Bente Jespersen, Kim Brixen, and Ebba Nexo

Sensitive Automated ELISA for Measurement of Vitamin D-Binding Protein (Gc) in Human Urine
Clin Chem 2005 51: 1016-1018. [Extract] [Full Text] [PDF]  

Pascal Mossuz, François Girodon, Sylvie Hermouet, Irène Dobo, Eric Lippert, Magali Donnard, Veronique Latger-Cannard, Nathalie Boiret, Vincent Praloran, and Jean Claude Lecron

Serum Erythropoietin Measured by Chemiluminescent Immunometric Assay: An Accurate Diagnostic Test for Absolute Erythrocytosis
Clin Chem 2005 51: 1018-1021. [Extract] [Full Text] [PDF]  

Mitsutoshi Sugano, Kazuyoshi Yamauchi, Keiko Sugano, Kenji Kawasaki, Minoru Tozuka, Tsutomu Katsuyama, Haruyo Soya, Tatsuhiko Tanaka, Shigeyuki Imamura, and Shozo Nomoto

New Enzymatic Assay Using Phospholipase D to Measure Total Calcium in Serum
Clin Chem 2005 51: 1021-1024. Published online April 1, 2005; 10.1373/clinchem.2004.047464 [Extract] [Full Text] [PDF] Data Supplements  

Paige B. Larrabee, Kirby L. Johnson, Inga Peter, and Diana W. Bianchi

Presence of Filterable and Nonfilterable Cell-Free mRNA in Amniotic Fluid
Clin Chem 2005 51: 1024-1026. [Extract] [Full Text] [PDF]  

Stefan Holdenrieder, Susanne Mueller, and Petra Stieber

Stability of Nucleosomal DNA Fragments in Serum
Clin Chem 2005 51: 1026-1029. [Extract] [Full Text] [PDF]  

Susan Pang, Julie Reeve, Michael Walker, and Carole Foy

Relative Quantification of Experimental Data from Antigen Particle Arrays
Clin Chem 2005 51: 1029-1031. [Extract] [Full Text] [PDF] Data Supplements  

Barbara Montaruli, Antonella Vaccarino, Cristina Foli, Cecilia Rus, Cecilia Agnes, Maddalena Saitta, and Mario Bazzan

Lupus Anticoagulant: Performance of a New, Fully Automated Commercial Screening and Confirmation Assay
Clin Chem 2005 51: 1031-1033. [Extract] [Full Text] [PDF]  

Ileana Herzum, Harald Renz, and Hans Günther Wahl

Immunochemical Quantification of Free Light Chains in Urine
Clin Chem 2005 51: 1033-1035. [Extract] [Full Text] [PDF]  

Dan L. Crimmins

Human N-Terminal proBNP Is a Monomer
Clin Chem 2005 51: 1035-1038. [Extract] [Full Text] [PDF]  

Hong-Gang Zhang, Cai Qi, Zhan-Hui Wang, Gang Jin, and Rui-Juan Xiu

Evaluation of a New CA15-3 Protein Assay Method: Optical Protein-Chip System for Clinical Application
Clin Chem 2005 51: 1038-1040. Published online April 7, 2005; 10.1373/clinchem.2004.043240 [Extract] [Full Text] [PDF] Data Supplements  

Sergei M. Danilov, Jaap Deinum, Irina V. Balyasnikova, Zhu-Li Sun, Cornelis Kramers, Carla E.M. Hollak, and Ronald F. Albrecht

Detection of Mutated Angiotensin I-Converting Enzyme by Serum/Plasma Analysis Using a Pair of Monoclonal Antibodies
Clin Chem 2005 51: 1040-1043. [Extract] [Full Text] [PDF] Data Supplement  

Matt J. Smith, Gabriella Pante-de-Sousa, Khalid K. Alharbi, Xiao-he Chen, Ian N.M. Day, and Keith R. Fox

Combination of His-Tagged T4 Endonuclease VII with Microplate Array Diagonal Gel Electrophoresis for High-Throughput Mutation Scanning
Clin Chem 2005 51: 1043-1046. [Extract] [Full Text] [PDF] Data Supplements  

Jean-Bernard Daeppen, Frederic Anex, Bernard Favrat, Alvine Bissery, Joelle Leutwyler, Roland Gammeter, Patrice Mangin, and Marc Augsburger

Carbohydrate-Deficient Transferrin Measured by Capillary Zone Electrophoresis and by Turbidimetric Immunoassay for Identification of Young Heavy Drinkers
Clin Chem 2005 51: 1046-1048. [Extract] [Full Text] [PDF] Data Supplements  

Paul C. Adams, David M. Reboussin, Cathie Leiendecker-Foster, Godfrey C. Moses, Gordon D. McLaren, Christine E. McLaren, Fitzroy W. Dawkins, Ishmael Kasvosve, Ron T. Acton, James C. Barton, Dan Zaccaro, Emily L. Harris, Richard Press, Henry Chang, and John H. Eckfeldt

Comparison of the Unsaturated Iron-Binding Capacity with Transferrin Saturation as a Screening Test to Detect C282Y Homozygotes for Hemochromatosis in 101 168 Participants in the Hemochromatosis and Iron Overload Screening (HEIRS) Study
Clin Chem 2005 51: 1048-1052. Published online April 15, 2005; 10.1373/clinchem.2005.048371 [Extract] [Full Text] [PDF] Data Supplements  

Arne Schneider, Benjamin Funk, Wolfgang Caspary, and Juergen Stein

Monoclonal versus Polyclonal ELISA for Assessment of Fecal Elastase Concentration: Pitfalls of a New Assay
Clin Chem 2005 51: 1052-1054. Published online April 21, 2005; 10.1373/clinchem.2004.046888 [Extract] [Full Text] [PDF]  

Anna Margrét Halldórsdóttir, Joshua Stoker, Rhonda Porche-Sorbet, and Charles S. Eby

Soluble CD40 Ligand Measurement Inaccuracies Attributable to Specimen Type, Processing Time, and ELISA Method
Clin Chem 2005 51: 1054-1057. [Extract] [Full Text] [PDF]  

Niki S.M. Schoonenboom, Cees Mulder, Hugo Vanderstichele, Yolande A.L. Pijnenburg, Gerard J. Van Kamp, Philip Scheltens, Pankaj D. Mehta, and Marinus A. Blankenstein

Differences and Similarities between Two Frequently Used Assays for Amyloid ß 42 in Cerebrospinal Fluid
Clin Chem 2005 51: 1057-1060. Published online April 21, 2005; 10.1373/clinchem.2005.048629 [Extract] [Full Text] [PDF] Data Supplements  

Dennis E. Freer

Observations on Heat/Humidity Denaturation of Enzymes in Filter-Paper Blood Spots from Newborns
Clin Chem 2005 51: 1060-1062. Published online April 21, 2005; 10.1373/clinchem.2005.049270 [Extract] [Full Text] [PDF]  

Leslie F. McCoy, M. Bridgette Bowen, Mary Xu, Huiping Chen, and Rosemary L. Schleicher

Improved HPLC Assay for Measuring Serum Vitamin C with 1-Methyluric Acid Used as an Electrochemically Active Internal Standard
Clin Chem 2005 51: 1062-1064. Published online April 28, 2005; 10.1373/clinchem.2004.046904 [Extract] [Full Text] [PDF] Data Supplements  

Case Reports:

Scott J. Cameron, Judith C. Hagedorn, Lori J. Sokoll, Patrizio Caturegli, and Paul W. Ladenson

Dysprealbuminemic Hyperthyroxinemia in a Patient with Hyperthyroid Graves Disease
Clin Chem 2005 51: 1065-1069. Published online April 15, 2005; 10.1373/clinchem.2005.050518 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Andries J. Bakker, Ageeth Bierma-Ram, Halbe Keidel, Haye Syperda, and Appie Zijlstra

(Micro)Albuminuria: Antigen Excess Detection in the Roche Modular Analyzer
Clin Chem 2005 51: 1070-1071. [Extract] [Full Text] [PDF] Data Supplement  

Kunihiro Iwahara, Chizuko Tanabe, Kozo Nishiyama, Hiroyuki Ohashi, and Masato Maekawa

Falsely High Serum Free Triiodothyronine and Free Thyroxine Concentrations Attributable to Anti-Diiodothyronine and Anti-Triiodothyronine Antibodies
Clin Chem 2005 51: 1071-1072. [Extract] [Full Text] [PDF] Data Supplements  

Pamela Leventis, Lisa Garrison, Margaret Sibley, Pamela Peterson, Martyn Egerton, Gerald Levin, and Patrick Kiely

Underestimation of Serum 25-Hydroxyvitamin D by the Nichols Advantage Assay in Patients Receiving Vitamin D Replacement Therapy
Clin Chem 2005 51: 1072-1074. [Extract] [Full Text] [PDF]  

Kastooriranganathan Ramakrishnan and Michael F. Holick

Underestimation of Serum 25-Hydroxyvitamin D by the Nichols Advantage Assay in Patients Receiving Vitamin D Replacement Therapy - Reply
Clin Chem 2005 51: 1074. [Extract] [Full Text] [PDF]  

Grace T.Y. Chung, Rossa W.K. Chiu, K.C. Allen Chan, Tze K. Lau, Tse N. Leung, Lin W. Chan, and Y.M. Dennis Lo

Detrimental Effect of Formaldehyde on Plasma RNA Detection
Clin Chem 2005 51: 1074-1076. [Extract] [Full Text] [PDF]  

Andrea Nauti, Alessandra Barassi, Giampaolo Merlini, and Gian Vico Melzi d’Eril

Paraprotein Interference in an Assay of Conjugated Bilirubin
Clin Chem 2005 51: 1076-1077. [Extract] [Full Text] [PDF]  

Chelsea A. Sheppard, Robert C. Allen, Garth E. Austin, Andrew N. Young, Maria A. Ribeiro, and Corinne R. Fantz

Paraprotein Interference in Automated Chemistry Analyzers
Clin Chem 2005 51: 1077-1078. [Extract] [Full Text] [PDF]  

Nina Rolf, Ralf Knoefler, Meinolf Suttorp, Harald Klüter, and Peter Bugert

Optimized Procedure for Platelet RNA Profiling from Blood Samples with Limited Platelet Numbers
Clin Chem 2005 51: 1078-1080. [Extract] [Full Text] [PDF]  

Simone M. Castro, Raquel Weber, Vivian Dadalt, Vanessa F. Santos, George J. Reclos, Kenneth A. Pass, and Roberto Giugliani

Evaluation of Glucose-6-Phosphate Dehydrogenase Stability in Blood Samples under Different Collection and Storage Conditions
Clin Chem 2005 51: 1080-1081. [Extract] [Full Text] [PDF]  

Mie Morimoto, Hidekatsu Yanai, and Kazuhiko Matsuno

Morphologic Changes in Urine Particles during the Menstrual Cycle
Clin Chem 2005 51: 1081-1082. [Extract] [Full Text] [PDF]  

Scott A. Lear

Waist Circumference Is Simpler than Body Mass Index
Clin Chem 2005 51: 1082-1084. [Extract] [Full Text] [PDF]  

Gerald M. Reaven

Dr. Reaven responds:
Clin Chem 2005 51: 1083-1084. [Extract] [Full Text] [PDF]  

Corrections:

Correction for Volume 51, Issue , p. 672
Clin Chem 2005 51: 1084. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Carol S. Norton-Wenzel

EP Evaluator, CD ROM, Release 6. Kennett Square, PA: David G. Rhoads Associates, CD ROM, manual of 415 pages plus 7 NCCLS Guidelines, 2004, price varies (as reviewed, $2795.00).
Clin Chem 2005 51: 1085-1086. [Extract] [Full Text] [PDF]  

Henry B. Hollinger

Physical Chemistry: Understanding Our Chemical World. Paul Monk. Chichester, West Sussex, England: John Wiley & Sons, Ltd., 2004, 618 pp., $44.95 (softcover). ISBN 0-471-49181-0.
Clin Chem 2005 51: 1086-1087. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor

Clin Chem 2005 51: 1088. [Extract] [Full Text] [PDF]  

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