Editorials:

Andreas R. Huber and Lorenz Risch

Recent Developments in the Evaluation of Glomerular Filtration Rate: Is There a Place for ß-Trace?
Clin Chem 2005 51: 1329-1330. [Extract] [Full Text] [PDF]  

Elaine Lyon

Discovering Rare Variants by Use of Melting Temperature Shifts Seen in Melting Curve Analysis
Clin Chem 2005 51: 1331-1332. [Extract] [Full Text] [PDF]  

Stephen R. Master

Diagnostic Proteomics: Back to Basics?
Clin Chem 2005 51: 1333-1334. [Extract] [Full Text] [PDF]  

Minireview:

Anne W.S. Rutjes, Johannes B. Reitsma, Jan P. Vandenbroucke, Afina S. Glas, and Patrick M.M. Bossuyt

Case–Control and Two-Gate Designs in Diagnostic Accuracy Studies
Clin Chem 2005 51: 1335-1341. Published online June 16, 2005; 10.1373/clinchem.2005.048595 [Abstract] [Full Text] [PDF]  

Reviews:

György Sölétormos, Axel Semjonow, Paul E.C. Sibley, Rolf Lamerz, Per Hyltoft Petersen, Walter Albrecht, Peter Bialk, Massimo Gion, Frank Junker, Hans-Peter Schmid, Hein Van Poppel on behalf of the European Group on Tumor Markers

Biological Variation of Total Prostate-Specific Antigen: A Survey of Published Estimates and Consequences for Clinical Practice
Clin Chem 2005 51: 1342-1351. Published online June 16, 2005; 10.1373/clinchem.2004.046086 [Abstract] [Full Text] [PDF]  

Point/Counterpoint:

Scott M. Grundy

Point: The Metabolic Syndrome Still Lives
Clin Chem 2005 51: 1352-1354. [Extract] [Full Text] [PDF]  

Gerald Reaven

Counterpoint: Just Being Alive Is Not Good Enough
Clin Chem 2005 51: 1354-1357. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Pasqualina Buono, Fabrizio Pasanisi, Carmela Nardelli, Luigi Ieno, Silvana Capone, Rosario Liguori, Carmine Finelli, Giovannangelo Oriani, Franco Contaldo, and Lucia Sacchetti

Six Novel Mutations in the Proopiomelanocortin and Melanocortin Receptor 4 Genes in Severely Obese Adults Living in Southern Italy
Clin Chem 2005 51: 1358-1364. Published online June 10, 2005; 10.1373/clinchem.2005.047886 [Abstract] [Full Text] [PDF] Data Supplements  

Barbara Chmielewicz, Andreas Nitsche, Brunhilde Schweiger, and Heinz Ellerbrok

Development of a PCR-Based Assay for Detection, Quantification, and Genotyping of Human Adenoviruses
Clin Chem 2005 51: 1365-1373. Published online June 10, 2005; 10.1373/clinchem.2004.045088 [Abstract] [Full Text] [PDF] Data Supplements  

Landry K. Kamdem, Frank Streit, Ulrich M. Zanger, Jürgen Brockmöller, Michael Oellerich, Victor W. Armstrong, and Leszek Wojnowski

Contribution of CYP3A5 to the in Vitro Hepatic Clearance of Tacrolimus
Clin Chem 2005 51: 1374-1381. Published online June 10, 2005; 10.1373/clinchem.2005.050047 [Abstract] [Full Text] [PDF] Data Supplements  

Yunfei Liang, Ying Wan, Li-wen Qiu, Jingran Zhou, Bing Ni, Bo Guo, Qiang Zou, Liyun Zou, Wei Zhou, Zhengcai Jia, Xiao-yan Che, and Yuzhang Wu

Comprehensive Antibody Epitope Mapping of the Nucleocapsid Protein of Severe Acute Respiratory Syndrome (SARS) Coronavirus: Insight into the Humoral Immunity of SARS
Clin Chem 2005 51: 1382-1396. Published online June 23, 2005; 10.1373/clinchem.2005.051045 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Henkjan Gellekink, Dinny van Oppenraaij-Emmerzaal, Arno van Rooij, Eduard A. Struys, Martin den Heijer, and Henk J. Blom

Stable-Isotope Dilution Liquid Chromatography–Electrospray Injection Tandem Mass Spectrometry Method for Fast, Selective Measurement of S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma
Clin Chem 2005 51: 1487-1492. Published online May 26, 2005; 10.1373/clinchem.2004.046995 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Xinhua Yu, David R. Jacobs, Jr, Pamela J. Schreiner, Myron D. Gross, Michael W. Steffes, and Myriam Fornage

The Uncoupling Protein 2 Ala55Val Polymorphism Is Associated with Diabetes Mellitus: The CARDIA Study
Clin Chem 2005 51: 1451-1456. Published online June 10, 2005; 10.1373/clinchem.2004.044859 [Abstract] [Full Text] [PDF]  

Martin Petersen, Marianne Dyrby, Søren Toubro, Søren Balling Engelsen, Lars Nørgaard, Henrik Toft Pedersen, and Jørn Dyerberg

Quantification of Lipoprotein Subclasses by Proton Nuclear Magnetic Resonance–Based Partial Least-Squares Regression Models
Clin Chem 2005 51: 1457-1461. Published online June 16, 2005; 10.1373/clinchem.2004.046748 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Junnichi Ishii, Yukio Ozaki, Jingchao Lu, Fumihiko Kitagawa, Takahiro Kuno, Tadashi Nakano, Yuu Nakamura, Hiroyuki Naruse, Yoshihisa Mori, Shigeru Matsui, Hisaji Oshima, Masanori Nomura, Kouji Ezaki, and Hitoshi Hishida

Prognostic Value of Serum Concentration of Heart-Type Fatty Acid–Binding Protein Relative to Cardiac Troponin T on Admission in the Early Hours of Acute Coronary Syndrome
Clin Chem 2005 51: 1397-1404. Published online June 10, 2005; 10.1373/clinchem.2004.047662 [Abstract] [Full Text] [PDF]  

Maria T. Sandri, Michela Salvatici, Daniela Cardinale, Laura Zorzino, Rita Passerini, Paola Lentati, Maria Leon, Maurizio Civelli, Giovanni Martinelli, and Carlo M. Cipolla

N-Terminal Pro-B-Type Natriuretic Peptide after High-Dose Chemotherapy: A Marker Predictive of Cardiac Dysfunction?
Clin Chem 2005 51: 1405-1410. Published online June 2, 2005; 10.1373/clinchem.2005.050153 [Abstract] [Full Text] [PDF]  

Glen L. Hortin and Bonnie Meilinger

Cross-Reactivity of Amino Acids and Other Compounds in the Biuret Reaction: Interference with Urinary Peptide Measurements
Clin Chem 2005 51: 1411-1419. Published online June 10, 2005; 10.1373/clinchem.2005.052019 [Abstract] [Full Text] [PDF]  

Anders Grubb, Ulf Nyman, Jonas Björk, Veronica Lindström, Bengt Rippe, Gunnar Sterner, and Anders Christensson

Simple Cystatin C–Based Prediction Equations for Glomerular Filtration Rate Compared with the Modification of Diet in Renal Disease Prediction Equation for Adults and the Schwartz and the Counahan–Barratt Prediction Equations for Children
Clin Chem 2005 51: 1420-1431. Published online June 16, 2005; 10.1373/clinchem.2005.051557 [Abstract] [Full Text] [PDF]  

Christina V. Obiezu, Shannon J.C. Shan, Antoninus Soosaipillai, Liu-Ying Luo, Linda Grass, Georgia Sotiropoulou, Constantina D. Petraki, Panos A. Papanastasiou, Michael A. Levesque, and Eleftherios P. Diamandis

Human Kallikrein 4: Quantitative Study in Tissues and Evidence for Its Secretion into Biological Fluids
Clin Chem 2005 51: 1432-1442. Published online June 16, 2005; 10.1373/clinchem.2005.049692 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

John P. Jakupciak, Peter E. Barker, Wendy Wang, Sudhir Srivastava, and Donald H. Atha

Preparation and Characterization of Candidate Reference Materials for Telomerase Assays
Clin Chem 2005 51: 1443-1450. Published online June 10, 2005; 10.1373/clinchem.2004.044727 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Laurent Knafo, Philippe Chessex, Thérèse Rouleau, and Jean-Claude Lavoie

Association between Hydrogen Peroxide-Dependent Byproducts of Ascorbic Acid and Increased Hepatic Acetyl-CoA Carboxylase Activity
Clin Chem 2005 51: 1462-1471. Published online June 10, 2005; 10.1373/clinchem.2005.050427 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Marion L. Cawood, Helen P. Field, Clive G. Ford, Scott Gillingwater, Andrew Kicman, David Cowan, and Julian H. Barth

Testosterone Measurement by Isotope-Dilution Liquid Chromatography–Tandem Mass Spectrometry: Validation of a Method for Routine Clinical Practice
Clin Chem 2005 51: 1472-1479. Published online June 16, 2005; 10.1373/clinchem.2004.044503 [Abstract] [Full Text] [PDF]  

Juergen Kratzsch, Georg Martin Fiedler, Alexander Leichtle, Matthias Brügel, Susanne Buchbinder, Lothar Otto, Osama Sabri, Gert Matthes, and Joachim Thiery

New Reference Intervals for Thyrotropin and Thyroid Hormones Based on National Academy of Clinical Biochemistry Criteria and Regular Ultrasonography of the Thyroid
Clin Chem 2005 51: 1480-1486. Published online June 16, 2005; 10.1373/clinchem.2004.047399 [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Krzysztof Safranow and Zygmunt Machoy

Methylated Purines in Urinary Stones
Clin Chem 2005 51: 1493-1498. Published online May 26, 2005; 10.1373/clinchem.2005.048033 [Abstract] [Full Text] [PDF]  

Glenn E. Palomaki, George J. Knight, Louis M. Neveux, Raj Pandian, and James E. Haddow

Maternal Serum Invasive Trophoblast Antigen and First-Trimester Down Syndrome Screening
Clin Chem 2005 51: 1499-1504. Published online June 16, 2005; 10.1373/clinchem.2005.050567 [Abstract] [Full Text] [PDF]  

Technical Briefs:

José Antonio Viedma, Noemí Garrigós, and Silvia Morales

Comparison of the Sensitivity of 2 Automated Immunoassays with Immunofixation Electrophoresis for Detecting Urine Bence Jones Proteins
Clin Chem 2005 51: 1505-1507. [Extract] [Full Text] [PDF]  

Siegfried Burggraf and Bernhard Olgemöller

Straightforward Procedure for Internal Control of Real-Time Reverse Transcription Amplification Assays
Clin Chem 2005 51: 1508-1510. [Extract] [Full Text] [PDF]  

Du Toit Loots, Elardus Erasmus, and Lodewyk J. Mienie

Identification of 19 New Metabolites Induced by Abnormal Amino Acid Conjugation in Isovaleric Acidemia
Clin Chem 2005 51: 1510-1512. [Extract] [Full Text] [PDF] Data Supplements  

Markus Herrmann, Ingrid Kindermann, Stephanie Müller, Thomas Georg, Michael Kindermann, Michael Böhm, and Wolfgang Herrmann

Relationship of Plasma Homocysteine with the Severity of Chronic Heart Failure
Clin Chem 2005 51: 1512-1515. [Extract] [Full Text] [PDF]  

Giuliana Cighetti, Rita Paroni, Silvia Marzorati, Erica Borotto, Riccardo Giudici, Gabriele Magnanini, and Gaetano Iapichino

Evaluation of Oxidative Stress in Serum of Critically Ill Patients by a Commercial Assay and Gas Chromatography–Mass Spectrometry
Clin Chem 2005 51: 1515-1517. [Extract] [Full Text] [PDF]  

Eleni Zygalaki, Aliki Stathopoulou, Christos Kroupis, Loukas Kaklamanis, Zenon Kyriakides, Dimitrios Kremastinos, and Evi S. Lianidou

Real-Time Reverse Transcription-PCR Quantification of Vascular Endothelial Growth Factor Splice Variants
Clin Chem 2005 51: 1518-1520. [Extract] [Full Text] [PDF] Supplemental Data  

Ji Wan Park, Terri H. Beaty, Paul Boyce, Alan F. Scott, and Iain McIntosh

Comparing Whole-Genome Amplification Methods and Sources of Biological Samples for Single-Nucleotide Polymorphism Genotyping
Clin Chem 2005 51: 1520-1523. [Extract] [Full Text] [PDF] Data Supplement  

Silke Grannemann, Olfert Landt, Sebastian Breuer, and Brunhilde Blömeke

LightTyper Assay with Locked-Nucleic-Acid–Modified Oligomers for Genotyping of the Toll-Like Receptor 4 Polymorphisms A896G and C1196T
Clin Chem 2005 51: 1523-1525. [Extract] [Full Text] [PDF]  

Aly Karsan, Bernhard J. Eigl, Stephane Flibotte, Karen Gelmon, Philip Switzer, Patricia Hassell, Dorothy Harrison, Jennifer Law, Malcolm Hayes, Moira Stillwell, Zhen Xiao, Thomas P. Conrads, and Timothy Veenstra

Analytical and Preanalytical Biases in Serum Proteomic Pattern Analysis for Breast Cancer Diagnosis
Clin Chem 2005 51: 1525-1528. Published online June 10, 2005; 10.1373/clinchem.2005.050708 [Extract] [Full Text] [PDF] Data Supplements  

Anders Helander, Jos P.M. Wielders, Riekie te Stroet, and Jonas P. Bergström

Comparison of HPLC and Capillary Electrophoresis for Confirmatory Testing of the Alcohol Misuse Marker Carbohydrate-Deficient Transferrin
Clin Chem 2005 51: 1528-1531. [Extract] [Full Text] [PDF]  

Uwe Pöge, Thomas M. Gerhardt, Birgit Stoffel-Wagner, Holger Palmedo, Hans-Ulrich Klehr, Tilman Sauerbruch, and Rainer P. Woitas

ß-Trace Protein Is an Alternative Marker for Glomerular Filtration Rate in Renal Transplantation Patients
Clin Chem 2005 51: 1531-1533. Published online June 10, 2005; 10.1373/clinchem.2005.048959 [Extract] [Full Text] [PDF]  

Mani S. Mahadevan and Paul V. Benson

Factor V Null Mutation Affecting the Roche LightCycler Factor V Leiden Assay
Clin Chem 2005 51: 1533-1535. [Extract] [Full Text] [PDF]  

Henriette de Loor, Bert Bammens, Pieter Evenepoel, Vicky De Preter, and Kristin Verbeke

Gas Chromatographic–Mass Spectrometric Analysis for Measurement of p-Cresol and Its Conjugated Metabolites in Uremic and Normal Serum
Clin Chem 2005 51: 1535-1538. [Extract] [Full Text] [PDF] Supplemental Data  

Catherine Alix-Panabières, Xavier Rebillard, Jean-Paul Brouillet, Eric Barbotte, François Iborra, Bruno Segui, Thierry Maudelonde, Colette Jolivet-Reynaud, and Jean-Pierre Vendrell

Detection of Circulating Prostate-Specific Antigen–Secreting Cells in Prostate Cancer Patients
Clin Chem 2005 51: 1538-1541. [Extract] [Full Text] [PDF] Data Supplements  

Bin Wang, Huaijun Zhu, Hong Sun, Jinshun Pan, Zhilan Yuan, and Rongbin Yu

Plasma 8-Isoprostane Concentrations in Patients with Age-Related Cataracts
Clin Chem 2005 51: 1541-1544. [Extract] [Full Text] [PDF]  

Stefan Holdenrieder, Petra Stieber, Lisa Y.S. Chan, Sandra Geiger, Andreas Kremer, Dorothea Nagel, and Y.M. Dennis Lo

Cell-Free DNA in Serum and Plasma: Comparison of ELISA and Quantitative PCR
Clin Chem 2005 51: 1544-1546. [Extract] [Full Text] [PDF] Data Supplements  

Werner Koch, Wolfgang Latz, Marianne Eichinger, Claudia Ganser, Albert Schömig, and Adnan Kastrati

Genotyping of the Angiotensin I-Converting Enzyme Gene Insertion/Deletion Polymorphism by the TaqMan Method
Clin Chem 2005 51: 1547-1549. [Extract] [Full Text] [PDF]  

Kristina Holmberg, Marie-Louise Persson, Mathias Uhlén, and Jacob Odeberg

Pyrosequencing Analysis of Thrombosis-Associated Risk Markers
Clin Chem 2005 51: 1549-1552. [Extract] [Full Text] [PDF] Data Supplements  

Vincent C.H. Lui, Thomas Y.Y. Leon, Maria-Mercedes Garcia-Barceló, Raymond W. Ganster, Benedict L.S. Chen, John M. Hutson, and Paul K.H. Tam

Novel RET Mutation Produces a Truncated RET Receptor Lacking the Intracellular Signaling Domain in a 3-Generation Family with Hirschsprung Disease
Clin Chem 2005 51: 1552-1554. [Extract] [Full Text] [PDF] Supplemental Data  

Roger R. Calam, Ibrahim Mansoor, and James Blaga

Homocysteine Stability in Heparinized Plasma Stored in a Gel Separator Tube
Clin Chem 2005 51: 1554-1555. [Extract] [Full Text] [PDF]  

Ashraf A. Bakkar, Viviane Quach, Anaïg Le Borgne, Marianne Toublanc, Dominique Henin, Hervé Wallerand, François Radvanyi, Hugues Bittard, Vincent Ravery, Laurent Boccon Gibod, Sixtina Gil Diez de Medina, Dominique K. Chopin, and Bernard Grandchamp

Sensitive Allele-Specific PCR Assay Able to Detect FGFR3 Mutations in Tumors and Urine from Patients with Urothelial Cell Carcinoma of the Bladder
Clin Chem 2005 51: 1555-1557. [Extract] [Full Text] [PDF] Data Supplements  

Patrick J. Twomey, Adie Viljoen, Ivan M. House, Timothy M. Reynolds, and Anthony S. Wierzbicki

Relationship between Serum Copper, Ceruloplasmin, and Non–Ceruloplasmin-Bound Copper in Routine Clinical Practice
Clin Chem 2005 51: 1558-1559. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Carmen G. Tag, Marie-Claire Schifflers, Monika Mohnen, Axel M. Gressner, and Ralf Weiskirchen

Atypical Melting Curve Resulting from Genetic Variation in the 3' Untranslated Region at Position 20218 in the Prothrombin Gene Analyzed with the LightCycler Factor II (Prothrombin) G20210A Assay
Clin Chem 2005 51: 1560-1561. [Extract] [Full Text] [PDF]  

Bernd Schmidt, Sabine Weickmann, Christian Witt, and Michael Fleischhacker

Improved Method for Isolating Cell-Free DNA
Clin Chem 2005 51: 1561-1563. [Extract] [Full Text] [PDF] Supplemental Data  

Mads Nybo, Per Grinsted, and Per E. Jørgensen

Blood Sampling: Is Fasting Properly Defined?
Clin Chem 2005 51: 1563-1564. [Extract] [Full Text] [PDF]  

Ralf Scheidhauer, Brunhilde Guessregen, Axel Hohl, and Torsten Arndt

Effects of Prolonged Ambient Storage of Sodium Fluoride/Heparin Specimens on Plasma Homocysteine
Clin Chem 2005 51: 1564-1565. [Extract] [Full Text] [PDF]  

Alan H. Terry, Tanya Sandrock, and A. Wayne Meikle

Measurement of 25-Hydroxyvitamin D by the Nichols ADVANTAGE, DiaSorin LIAISON, DiaSorin RIA, and Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2005 51: 1565-1566. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Renze Bais

Clinical Chemistry: Principles, Procedures, Correlations, 5th ed. Michael L. Bishop, Edward P. Fody, and Larry Schoeff. Baltimore, MD: Lippincott Williams & Wilkins, 2005, 756 pp., $76.95, hardcover. ISBN 0-7817-4611-6.
Clin Chem 2005 51: 1567. [Extract] [Full Text] [PDF]  

Saeed A. Jortani

Toxicogenomics: Principles and Applications. Hisham K. Hamadeh and Cynthia A. Afshari. Hoboken, NJ: John Wiley and Sons, Inc., 361 pp., $64.95, hardcover. ISBN 0-417-43417-5.
Clin Chem 2005 51: 1568. [Extract] [Full Text] [PDF]  

Allan Sniderman

Atherosclerosis Risk Factors. James J. Maciejko. Washington, DC: AACC Press, 2004, 192 pp., $49.00 ($39.00 AACC members), softcover. ISBN 1-59425-004-9.
Clin Chem 2005 51: 1568. [Extract] [Full Text] [PDF]  

Corrections:

Correction for Volume 51, Issue , p. 240
Clin Chem 2005 51: 1566. [Extract] [Full Text] [PDF]  

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