Minireview:

Michael J. Duffy

Serum Tumor Markers in Breast Cancer: Are They of Clinical Value?
Clin Chem 2006 52: 345-351. Published online January 12, 2006; 10.1373/clinchem.2005.059832 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Hironobu Sanada, Junichi Yatabe, Sanae Midorikawa, Shigeatsu Hashimoto, Tsuyoshi Watanabe, Jason H. Moore, Marylyn D. Ritchie, Scott M. Williams, John C. Pezzullo, Midori Sasaki, Gilbert M. Eisner, Pedro A. Jose, and Robin A. Felder

Single-Nucleotide Polymorphisms for Diagnosis of Salt-Sensitive Hypertension
Clin Chem 2006 52: 352-360. Published online January 26, 2006; 10.1373/clinchem.2005.059139 [Abstract] [Full Text] [PDF] Data Supplements  

Hung-Yi Kao, Yi-Ning Su, Hsin-Kai Liao, Ming S. Liu, and Yu-Ju Chen

Determination of SMN1/SMN2 Gene Dosage by a Quantitative Genotyping Platform Combining Capillary Electrophoresis and MALDI-TOF Mass Spectrometry
Clin Chem 2006 52: 361-369. Published online January 26, 2006; 10.1373/clinchem.2005.061192 [Abstract] [Full Text] [PDF] Data Supplements  

Nobuhiro Hata, Koji Yoshimoto, Nobuhiko Yokoyama, Masahiro Mizoguchi, Tadahisa Shono, Yanlei Guan, Tomoko Tahira, Yoji Kukita, Koichiro Higasa, Shinji Nagata, Toru Iwaki, Tomio Sasaki, and Kenshi Hayashi

Allelic Losses of Chromosome 10 in Glioma Tissues Detected by Quantitative Single-Strand Conformation Polymorphism Analysis
Clin Chem 2006 52: 370-378. Published online January 5, 2006; 10.1373/clinchem.2005.060954 [Abstract] [Full Text] [PDF] Data Supplements  

Vijayakrishna K. Gadi, J. Lee Nelson, Nicholas D. Boespflug, Katherine A. Guthrie, and Christian S. Kuhr

Soluble Donor DNA Concentrations in Recipient Serum Correlate with Pancreas-Kidney Rejection
Clin Chem 2006 52: 379-382. Published online January 5, 2006; 10.1373/clinchem.2005.058974 [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Boris T. Ivandic, Philipp Schlick, Peter Staritz, Kerstin Kurz, Hugo A. Katus, and Evangelos Giannitsis

Determination of Clopidogrel Resistance by Whole Blood Platelet Aggregometry and Inhibitors of the P2Y₁₂ Receptor
Clin Chem 2006 52: 383-388. Published online January 19, 2006; 10.1373/clinchem.2005.059535 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Denis Sviridov, Bonnie Meilinger, Steven K. Drake, Gerard T. Hoehn, and Glen L. Hortin

Coelution of Other Proteins with Albumin during Size-Exclusion HPLC: Implications for Analysis of Urinary Albumin
Clin Chem 2006 52: 389-397. Published online January 5, 2006; 10.1373/clinchem.2005.057323 [Abstract] [Full Text] [PDF]  

Qiu-Ping Qin, Saara Kokkala, Juha Lund, Natalia Tamm, Xuezhong Qin, Mauri Lepäntalo, and Kim Pettersson

Immunoassays Developed for Pregnancy-Associated Plasma Protein-A (PAPP-A) in Pregnancy May Not Recognize PAPP-A in Acute Coronary Syndromes
Clin Chem 2006 52: 398-404. Published online January 19, 2006; 10.1373/clinchem.2005.058396 [Abstract] [Full Text] [PDF]  

Aimin Xu, Yu Wang, Jian Yu Xu, David Stejskal, Sidney Tam, Jialiang Zhang, Nelson M.S. Wat, Wai Keung Wong, and Karen S.L. Lam

Adipocyte Fatty Acid–Binding Protein Is a Plasma Biomarker Closely Associated with Obesity and Metabolic Syndrome
Clin Chem 2006 52: 405-413. Published online January 19, 2006; 10.1373/clinchem.2005.062463 [Abstract] [Full Text] [PDF]  

Michael N. Fahie-Wilson, David J. Carmichael, Michael P. Delaney, Paul E. Stevens, Elizabeth M. Hall, and Edmund J. Lamb

Cardiac Troponin T Circulates in the Free, Intact Form in Patients with Kidney Failure
Clin Chem 2006 52: 414-420. Published online January 12, 2006; 10.1373/clinchem.2005.062307 [Abstract] [Full Text] [PDF]  

Ronald T.K. Pang, Terence C.W. Poon, K.C. Allen Chan, Nelson L.S. Lee, Rossa W.K. Chiu, Yu-Kwan Tong, Ronald M.Y. Wong, Stephen S.C. Chim, Sai M. Ngai, Joseph J.Y. Sung, and Y.M. Dennis Lo

Serum Proteomic Fingerprints of Adult Patients with Severe Acute Respiratory Syndrome
Clin Chem 2006 52: 421-429. Published online January 19, 2006; 10.1373/clinchem.2005.061689 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Barbara K. Zehentner, Wayne Fritschle, Tess Stelzer, Keely M. Ghirardelli, Kimberly Hunter, Collette Wentzel, Richard Bennington, Christian L. Hansen, David Myerson, Michael Kalnoski, Denise A. Wells, and Michael R. Loken

Minimal Disease Detection and Confirmation in Hematologic Malignancies: Combining Cell Sorting with Clonality Profiling
Clin Chem 2006 52: 430-437. Published online January 12, 2006; 10.1373/clinchem.2005.061259 [Abstract] [Full Text] [PDF]  

Katrien Swerts, Barbara De Moerloose, Catharina Dhooge, Jo Vandesompele, Claire Hoyoux, Klaus Beiske, Yves Benoit, Geneviève Laureys, and Jan Philippé

Potential Application of ELAVL4 Real-Time Quantitative Reverse Transcription-PCR for Detection of Disseminated Neuroblastoma Cells
Clin Chem 2006 52: 438-445. Published online December 29, 2005; 10.1373/clinchem.2005.059485 [Abstract] [Full Text] [PDF] Data Supplements  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Jeffrey W. Stephens, David R. Gable, Steven J. Hurel, George J. Miller, Jackie A. Cooper, and Steve E. Humphries

Increased Plasma Markers of Oxidative Stress Are Associated with Coronary Heart Disease in Males with Diabetes Mellitus and with 10-Year Risk in a Prospective Sample of Males
Clin Chem 2006 52: 446-452. Published online December 29, 2005; 10.1373/clinchem.2005.060194 [Abstract] [Full Text] [PDF]  

Valentine Charlton-Menys, Yifen Liu, and Paul N. Durrington

Semiautomated Method for Determination of Serum Paraoxonase Activity Using Paraoxon as Substrate
Clin Chem 2006 52: 453-457. Published online January 19, 2006; 10.1373/clinchem.2005.063412 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Karen E. Murphy, Michele M. Schantz, Therese A. Butler, Bruce A. Benner, Jr, Laura J. Wood, and Gregory C. Turk

Determination of Cyanide in Blood by Isotope-Dilution Gas Chromatography–Mass Spectrometry
Clin Chem 2006 52: 458-467. Published online January 26, 2006; 10.1373/clinchem.2005.061002 [Abstract] [Full Text] [PDF] Data Supplement  

Endocrinology and Metabolism:

Helene Markkanen, Tuula Pekkarinen, Matti J. Välimäki, Henrik Alfthan, Ritva Kauppinen-Mäkelin, Timo Sane, and Ulf-Håkan Stenman

Effect of Sex and Assay Method on Serum Concentrations of Growth Hormone in Patients with Acromegaly and in Healthy Controls
Clin Chem 2006 52: 468-473. Published online January 26, 2006; 10.1373/clinchem.2005.060236 [Abstract] [Full Text] [PDF]  

Frank Giton, Jean Fiet, Jérôme Guéchot, Fidaa Ibrahim, Françoise Bronsard, Dominique Chopin, and Jean-Pierre Raynaud

Serum Bioavailable Testosterone: Assayed or Calculated?
Clin Chem 2006 52: 474-481. Published online December 29, 2005; 10.1373/clinchem.2005.052126 [Abstract] [Full Text] [PDF]  

Johannes Sander, Nils Janzen, Michael Peter, Stefanie Sander, Ulrike Steuerwald, Ute Holtkamp, Bernd Schwahn, Ertan Mayatepek, Friedrich K. Trefz, and Anibh M. Das

Newborn Screening for Hepatorenal Tyrosinemia: Tandem Mass Spectrometric Quantification of Succinylacetone
Clin Chem 2006 52: 482-487. Published online January 26, 2006; 10.1373/clinchem.2005.059790 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Jens Martens-Lobenhoffer and Stefanie M. Bode-Böger

Fast and Efficient Determination of Arginine, Symmetric Dimethylarginine, and Asymmetric Dimethylarginine in Biological Fluids by Hydrophilic-Interaction Liquid Chromatography–Electrospray Tandem Mass Spectrometry
Clin Chem 2006 52: 488-493. Published online December 29, 2005; 10.1373/clinchem.2005.060152 [Abstract] [Full Text] [PDF] Data Supplement  

Mark G. Herrmann, Jacob D. Durtschi, L. Kathryn Bromley, Carl T. Wittwer, and Karl V. Voelkerding

Amplicon DNA Melting Analysis for Mutation Scanning and Genotyping: Cross-Platform Comparison of Instruments and Dyes
Clin Chem 2006 52: 494-503. Published online January 19, 2006; 10.1373/clinchem.2005.063438 [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Hind Berrahmoune, John V. Lamont, Bernard Herbeth, Peter S. FitzGerald, and Sophie Visvikis-Siest

Biological Determinants of and Reference Values for Plasma Interleukin-8, Monocyte Chemoattractant Protein-1, Epidermal Growth Factor, and Vascular Endothelial Growth Factor: Results from the STANISLAS Cohort
Clin Chem 2006 52: 504-510. Published online January 19, 2006; 10.1373/clinchem.2005.055798 [Abstract] [Full Text] [PDF] Data Supplement  

Technical Briefs:

Georg Endler, Rodrig Marculescu, Philipp Starkl, Alexander Binder, Gotho Geishofer, Martin Müller, Bettina Zöhrer, Bernhard Resch, Werner Zenz, Christine Mannhalter for the Central European Meningococcal Genetic Study Group

Polymorphisms in the Interleukin-1 Gene Cluster in Children and Young Adults with Systemic Meningococcemia
Clin Chem 2006 52: 511-514. [Abstract] [Full Text] [PDF]  

William E. Alborn, Melvin G. Johnson, Melvin J. Prince, and Robert J. Konrad

Definitive N-Terminal Protein Sequence and Further Characterization of the Novel Apolipoprotein A5 in Human Serum
Clin Chem 2006 52: 514-517. [Abstract] [Full Text] [PDF]  

Ching-Wan Lam and Chloe M. Mak

Allele Dropout in PCR-Based Diagnosis of Wilson Disease: Mechanisms and Solutions
Clin Chem 2006 52: 517-520. [Abstract] [Full Text] [PDF] Data Supplements  

Liqiang Xi, William Gooding, Kenneth McCarty, Tony E. Godfrey, and Steven J. Hughes

Identification of mRNA Markers for Molecular Staging of Lymph Nodes in Colorectal Cancer
Clin Chem 2006 52: 520-523. [Abstract] [Full Text] [PDF] Data Supplements  

Johanna Atamaniuk, Katharina Ruzicka, Karl M. Stuhlmeier, Alireza Karimi, Manfred Eigner, and Mathias M. Mueller

Cell-Free Plasma DNA: A Marker for Apoptosis during Hemodialysis
Clin Chem 2006 52: 523-526. [Abstract] [Full Text] [PDF]  

Wayne Dimech, Barbara Francis, Jennifer Kox, Graham Roberts for the Serology Uncertainty of Measurement Working Party

Calculating Uncertainty of Measurement for Serology Assays by Use of Precision and Bias
Clin Chem 2006 52: 526-529. Published online January 12, 2006; 10.1373/clinchem.2005.056689 [Abstract] [Full Text] [PDF] Data Supplements  

Case Reports:

Anibh M. Das, Sabine Illsinger, Thomas Lücke, Hans Hartmann, Jos P.N. Ruiter, Ulrike Steuerwald, Hans R. Waterham, Marinus Duran, and Ronald J.A. Wanders

Isolated Mitochondrial Long-Chain Ketoacyl-CoA Thiolase Deficiency Resulting from Mutations in the HADHB Gene
Clin Chem 2006 52: 530-534. Published online January 19, 2006; 10.1373/clinchem.2005.062000 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Olivier W.V. van den Brink, Michael A. Rowland, Silvana F. Marasco, Donald S. Esmore, Franklin L. Rosenfeldt, and Salvatore Pepe

Complex Regional Pain Syndrome and Methionine-Enkephalin
Clin Chem 2006 52: 535. [Extract] [Full Text] [PDF]  

Amy Yuk-Yin Chan, Hong-Yuan Luo, Wen Wang, David H.K. Chui, Edmond Shiu-Kwan Ma, Li-Chong Chan, and Samuel S. Chong

Diagnostic Pitfall in PCR-Based -Thalassemia Genotyping Resulting from a (GC) Polymorphism at Nucleotide 71 3' to the 2-Globin Gene Termination Codon
Clin Chem 2006 52: 536-537. [Extract] [Full Text] [PDF]  

Giuseppe Lippi, Gian Luca Salvagno, Martina Montagnana, Giovanni Poli, and Gian Cesare Guidi

Influence of Centrifuge Temperature on Routine Coagulation Testing
Clin Chem 2006 52: 537-538. [Extract] [Full Text] [PDF]  

Cláudia M.B. Carvalho, Walter Camargos, and Sérgio D.J. Pena

Multiplex Protocol Suitable for Screening for MECP2 Mutations in Girls with Mental Retardation
Clin Chem 2006 52: 539-540. [Extract] [Full Text] [PDF] Data Supplement  

Julie D. Newman, Philip B. Bergman, James C.G. Doery, and Nicholas D.H. Balazs

Factitious Increase in Thyrotropin in a Neonate Caused by a Maternally Transmitted Interfering Substance
Clin Chem 2006 52: 541-542. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Curtis A. Parvin

dr-ROC Software. Mathew D. Mitchell. Glenside, PA: Dr2Consulting, 2005, CD. Individual license, $150.00; Departmental license, $400.00; Commercial license, $500.00; Student/resident license, $105.00.
Clin Chem 2006 52: 543-544. [Extract] [Full Text] [PDF]  

Ferruccio Ceriotti

Pediatric References Intervals, 5th Edition (formerly Pediatric Reference Ranges). Steven J. Soldin, Carlo Brugnara, and Edward C. Wong, editors; Jocelyn M. Hicks, editor emeritus. Washington, DC: AACC Press, 2005, 257 pp., $75.00 ($60.00 AACC members), softcover. ISBN 1-594250-32-4.
Clin Chem 2006 52: 544. [Extract] [Full Text] [PDF]  

Ferruccio Ceriotti

Reference Intervals: A User’s Guide. Paul S. Horn and Amadeo J. Pesce. Washington, DC: AACC Press, 2005, 115 pp., $61.00 ($49.00 AACC members), softcover (CD-ROM included). ISBN 1-59425-035-9.
Clin Chem 2006 52: 544-545. [Extract] [Full Text] [PDF]  

San Diego Conference:

The 20th Anniversary San Diego Conference DNA Probe Technology — Two Decades of Innovation March 16–18, 2006 San Diego, CA: Poster Session Abstracts
Clin Chem 2006 52: 546-548. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

David E. Bruns

The Clinical Chemist
Clin Chem 2006 52: 549-552. [Extract] [Full Text] [PDF]  

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