Editorials:

W. Greg Miller, Gary L. Myers, and Robert Rej

Why Commutability Matters
Clin Chem 2006 52: 553-554. [Extract] [Full Text] [PDF]  

Theodore Peters, Jr

How Should We Measure the Albumin in Urine?
Clin Chem 2006 52: 555-556. [Extract] [Full Text] [PDF]  

Egbert Bakker

Is the DNA Sequence the Gold Standard in Genetic Testing? Quality of Molecular Genetic Tests Assessed
Clin Chem 2006 52: 557-558. [Extract] [Full Text] [PDF]  

Lee Ann Baxter-Lowe and Michael P. Busch

Tracking Microchimeric DNA in Plasma to Diagnose and Manage Organ Transplant Rejection
Clin Chem 2006 52: 559-561. [Extract] [Full Text] [PDF]  

Reviews:

Heiko Müller and Hermann Brenner

Urine Markers as Possible Tools for Prostate Cancer Screening: Review of Performance Characteristics and Practicality
Clin Chem 2006 52: 562-573. Published online February 16, 2006; 10.1373/clinchem.2005.062919 [Abstract] [Full Text] [PDF]  

Suzan Wopereis, Dirk J. Lefeber, Éva Morava, and Ron A. Wevers

Mechanisms in Protein O-Glycan Biosynthesis and Clinical and Molecular Aspects of Protein O-Glycan Biosynthesis Defects: A Review
Clin Chem 2006 52: 574-600. Published online February 23, 2006; 10.1373/clinchem.2005.063040 [Abstract] [Full Text] [PDF]  

Isabella Dalle-Donne, Ranieri Rossi, Roberto Colombo, Daniela Giustarini, and Aldo Milzani

Biomarkers of Oxidative Damage in Human Disease
Clin Chem 2006 52: 601-623. Published online February 16, 2006; 10.1373/clinchem.2005.061408 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Jin Li, Fengfei Wang, Harvey Mamon, Matthew H. Kulke, Lyndsay Harris, Elizabeth Maher, Lilin Wang, and G. Mike Makrigiorgos

Antiprimer Quenching-Based Real-Time PCR and Its Application to the Analysis of Clinical Cancer Samples
Clin Chem 2006 52: 624-633. Published online February 9, 2006; 10.1373/clinchem.2005.063321 [Abstract] [Full Text] [PDF] Data Supplements  

Masato Mitsuhashi, Shigeru Tomozawa, Katsuya Endo, and Atsushi Shinagawa

Quantification of mRNA in Whole Blood by Assessing Recovery of RNA and Efficiency of cDNA Synthesis
Clin Chem 2006 52: 634-642. Published online February 23, 2006; 10.1373/clinchem.2005.048983 [Abstract] [Full Text] [PDF] Data Supplements  

Caroline J. Dean, Michelle R. Bockmann, John J. Hopwood, Doug A. Brooks, and Peter J. Meikle

Detection of Mucopolysaccharidosis Type II by Measurement of Iduronate-2-Sulfatase in Dried Blood Spots and Plasma Samples
Clin Chem 2006 52: 643-649. Published online February 23, 2006; 10.1373/clinchem.2005.061838 [Abstract] [Full Text] [PDF]  

Evidence-Based Laboratory Medicine and Test Utilization:

Aasne K. Aarsand, Per Hyltoft Petersen, and Sverre Sandberg

Estimation and Application of Biological Variation of Urinary -Aminolevulinic Acid and Porphobilinogen in Healthy Individuals and in Patients with Acute Intermittent Porphyria
Clin Chem 2006 52: 650-656. [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

P. Marc van der Zee, Éva Biró, Yung Ko, Robbert J. de Winter, C. Erik Hack, Augueste Sturk, and Rienk Nieuwland

P-Selectin- and CD63-Exposing Platelet Microparticles Reflect Platelet Activation in Peripheral Arterial Disease and Myocardial Infarction
Clin Chem 2006 52: 657-664. Published online January 26, 2006; 10.1373/clinchem.2005.057414 [Abstract] [Full Text] [PDF]  

Nathalie Hézard, Lobna Bouaziz-Borgi, Marie-Geneviève Remy, and Philippe Nguyen

Utility of Thrombin-Generation Assay in the Screening of Factor V G1691A (Leiden) and Prothrombin G20210A Mutations and Protein S Deficiency
Clin Chem 2006 52: 665-670. Published online February 9, 2006; 10.1373/clinchem.2005.063339 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Amelie Plymoth, Ziping Yang, Claes-Göran Löfdahl, Ann Ekberg-Jansson, Magnus Dahlbäck, Thomas E. Fehniger, György Marko-Varga, and William S. Hancock

Rapid Proteome Analysis of Bronchoalveolar Lavage Samples of Lifelong Smokers and Never-Smokers by Micro-Scale Liquid Chromatography and Mass Spectrometry
Clin Chem 2006 52: 671-679. Published online February 23, 2006; 10.1373/clinchem.2005.060715 [Abstract] [Full Text] [PDF] Data Supplements  

John V. St. Peter, Guilford G. Hartley, MaryAnn M. Murakami, and Fred S. Apple

B-Type Natriuretic Peptide (BNP) and N-Terminal Pro-BNP in Obese Patients without Heart Failure: Relationship to Body Mass Index and Gastric Bypass Surgery
Clin Chem 2006 52: 680-685. Published online February 23, 2006; 10.1373/clinchem.2005.062562 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Adrienne C.M. Persoon, Johannes M.W. Van Den Ouweland, Juergen Wilde, Ido P. Kema, Bruce H.R. Wolffenbuttel, and Thera P. Links

Clinical Utility of an Automated Immunochemiluminometric Thyroglobulin Assay in Differentiated Thyroid Carcinoma
Clin Chem 2006 52: 686-691. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Jaroslav Sterba, Ladislav Dusek, Regina Demlova, and Dalibor Valik

Pretreatment Plasma Folate Modulates the Pharmacodynamic Effect of High-Dose Methotrexate in Children with Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma: "Folate Overrescue" Concept Revisited
Clin Chem 2006 52: 692-700. Published online February 2, 2006; 10.1373/clinchem.2005.061150 [Abstract] [Full Text] [PDF] Data Supplement  

Endocrinology and Metabolism:

Ylva Floderus, Eliane Sardh, Christer Möller, Claes Andersson, Lillan Rejkjaer, Dan E.H. Andersson, and Pauline Harper

Variations in Porphobilinogen and 5-Aminolevulinic Acid Concentrations in Plasma and Urine from Asymptomatic Carriers of the Acute Intermittent Porphyria Gene with Increased Porphyrin Precursor Excretion
Clin Chem 2006 52: 701-707. Published online February 23, 2006; 10.1373/clinchem.2005.058198 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Florin Marcel Musteata, Mihaela L. Musteata, and Janusz Pawliszyn

Fast In Vivo Microextraction: A New Tool for Clinical Analysis
Clin Chem 2006 52: 708-715. Published online February 23, 2006; 10.1373/clinchem.2005.064758 [Abstract] [Full Text] [PDF]  

Laboratory Management:

Parviz Ahmad-Nejad, Alexandra Dorn-Beineke, Ulrike Pfeiffer, Joachim Brade, Wolf-Jochen Geilenkeuser, Simon Ramsden, Mario Pazzagli, and Michael Neumaier

Methodologic European External Quality Assurance for DNA Sequencing: The EQUALseq Program
Clin Chem 2006 52: 716-727. Published online January 26, 2006; 10.1373/clinchem.2005.061572 [Abstract] [Full Text] [PDF] Data Supplements  

Simon J. Patton, Andrew J. Wallace, and Rob Elles

Benchmark for Evaluating the Quality of DNA Sequencing: Proposal from an International External Quality Assessment Scheme
Clin Chem 2006 52: 728-736. Published online February 2, 2006; 10.1373/clinchem.2005.061887 [Abstract] [Full Text] [PDF] Data Supplements  

Technical Briefs:

John Krahn and Annu Khajuria

Osmolality Gaps: Diagnostic Accuracy and Long-Term Variability
Clin Chem 2006 52: 737-739. Published online February 2, 2006; 10.1373/clinchem.2005.057695 [Abstract] [Full Text] [PDF]  

Patrizia Piccioli, Martina Serra, Viviana Gismondi, Simona Pedemonte, Fabrizio Loiacono, Sonia Lastraioli, Lucio Bertario, Maria De Angioletti, Liliana Varesco, and Rosario Notaro

Multiplex Tetra-Primer Amplification Refractory Mutation System PCR to Detect 6 Common Germline Mutations of the MUTYH Gene Associated with Polyposis and Colorectal Cancer
Clin Chem 2006 52: 739-743. Published online February 2, 2006; 10.1373/clinchem.2005.060137 [Abstract] [Full Text] [PDF] Data Supplements  

Alison Woodworth, Al N. Saunders, John W. Koenig, Thomas P. Moyer, John Turk, and Dennis J. Dietzen

Differentiation of Amphetamine/Methamphetamine and Other Cross-Immunoreactive Sympathomimetic Amines in Urine Samples by Serial Dilution Testing
Clin Chem 2006 52: 743-746. Published online February 2, 2006; 10.1373/clinchem.2005.060616 [Abstract] [Full Text] [PDF] Data Supplements  

Suhail A.R. Doi, Ibrahim Lasheen, Khaldoon Al-Humood, and Kamal A.S. Al-Shoumer

Relationship between Cortisol Increment and Basal Cortisol: Implications for the Low-Dose Short Adrenocorticotropic Hormone Stimulation Test
Clin Chem 2006 52: 746-749. Published online February 9, 2006; 10.1373/clinchem.2005.061267 [Abstract] [Full Text] [PDF]  

Elena Roura, Cristina Andrés-Lacueva, Ramon Estruch, and Rosa M. Lamuela-Raventós

Total Polyphenol Intake Estimated by a Modified Folin–Ciocalteu Assay of Urine
Clin Chem 2006 52: 749-752. Published online February 9, 2006; 10.1373/clinchem.2005.063628 [Abstract] [Full Text] [PDF]  

Peter Kupchak, Alan H.B. Wu, Farooq Ghani, L. Kristen Newby, E. Magnus Ohman, and Robert H. Christenson

Influence of Imprecision on ROC Curve Analysis for Cardiac Markers
Clin Chem 2006 52: 752-753. Published online February 9, 2006; 10.1373/clinchem.2005.064477 [Abstract] [Full Text] [PDF]  

Anne Schmedes and Ivan Brandslund

Analysis of Methylmalonic Acid in Plasma by Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2006 52: 754-757. [Abstract] [Full Text] [PDF] Data Supplements  

Philippe Boudou, Fidaa Ibrahim, Catherine Cormier, Emile Sarfati, and Jean-Claude Souberbielle

Unexpected Serum Parathyroid Hormone Profiles in Some Patients with Primary Hyperparathyroidism
Clin Chem 2006 52: 757-760. Published online February 23, 2006; 10.1373/clinchem.2005.060962 [Abstract] [Full Text] [PDF]  

Paul Holvoet, Elizabeth Macy, Michele Landeloos, Dan Jones, Jenny S. Nancy, Frans Van de Werf, and Russell P. Tracy

Analytical Performance and Diagnostic Accuracy of Immunometric Assays for the Measurement of Circulating Oxidized LDL
Clin Chem 2006 52: 760-764. Published online February 23, 2006; 10.1373/clinchem.2005.064337 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Kimberly L. Napoli

Organic Solvents Compromise Performance of Internal Standard (Ascomycin) in Proficiency Testing of Mass Spectrometry-Based Assays for Tacrolimus
Clin Chem 2006 52: 765-766. [Extract] [Full Text] [PDF] Data Supplement  

Damien Gruson, Michel F. Rousseau, Virginie de Coninck, Sylvie A. Ahn, and Jean-Marie Ketelslegers

Influence of Sampling and Storage Conditions on B-Type Natriuretic Peptide Immunoreactivity for 3 Automated Assays
Clin Chem 2006 52: 766-767. [Extract] [Full Text] [PDF]  

Michael A. Linden and Fred S. Apple

Use of B-Type Natriuretic Peptide Testing in a Community Teaching Hospital 4 Years After Implementation and Agreement of Results with Discharge Diagnoses
Clin Chem 2006 52: 767-768. [Extract] [Full Text] [PDF]  

Maaike W. Rautenberg, Wouter W. van Solinge, Juliska J. Heunks, Ron H. Stokwielder, Eef G.W.M. Lentjes, and Hans Kemperman

Pediatric Tube Direct Sampling by the Abbott Architect Integrated ci8200 Chemistry/Immunochemistry Analyzer
Clin Chem 2006 52: 768-770. [Extract] [Full Text] [PDF] Data Supplement  

Abdurrahman Coskun

Six Sigma and Calculated Laboratory Tests
Clin Chem 2006 52: 770-771. [Extract] [Full Text] [PDF]  

Eleftherios P. Diamandis

Validation of Breast Cancer Biomarkers Identified by Mass Spectrometry
Clin Chem 2006 52: 771-772. [Extract] [Full Text] [PDF]  

Jinong Li, Zhen Zhang, and Daniel W. Chan

Validation of Breast Cancer Biomarkers Identified by Mass Spectrometry: Some of the authors of the article cited above respond:
Clin Chem 2006 52: 772. [Extract] [Full Text] [PDF]  

Ilenia Infusino, Paola Luraschi, Mauro Panteghini, and Carlo Franzini

Pretreatment of Serum with Penicillamine: Effects on Capillary Electrophoresis Patterns and on Immunonephelometric Measurement of Immunoglobulins
Clin Chem 2006 52: 772-774. [Extract] [Full Text] [PDF]  

Hubert A. Carchon, Célestin Nsibu Ndosimao, Sandra Van Aerschot, and Jaak Jaeken

Use of Serum on Guthrie Cards in Screening for Congenital Disorders of Glycosylation
Clin Chem 2006 52: 774-775. [Extract] [Full Text] [PDF]  

David Cheillan, Gajja S. Salomons, Cécile Acquaviva, Catherine Boisson, Philippe Roth, Marie-Pierre Cordier, Laurence François, Cornelis Jakobs, and Christine Vianey-Saban

Prenatal Diagnosis of Guanidinoacetate Methyltransferase Deficiency: Increased Guanidinoacetate Concentrations in Amniotic Fluid
Clin Chem 2006 52: 775-777. [Extract] [Full Text] [PDF]  

Demosthenes Bouros, Argyris Tzouvelekis, Stavros Anevlavis, Michael Doris, Stavros Tryfon, Marios Froudarakis, Vasiliki Zournatzi, and Asterios Kukuvitis

Smoking Acutely Increases Plasma Ghrelin Concentrations
Clin Chem 2006 52: 777-778. [Extract] [Full Text] [PDF]  

Girish S. Hiremath, David J. Sullivan, Jr, Abhai K. Tripathi, Robert E. Black, and Sunil Sazawal

Effect of Plasmodium falciparum Parasitemia on Erythrocyte Zinc Protoporphyrin
Clin Chem 2006 52: 778-779. [Extract] [Full Text] [PDF]  

David García-Yoldi, Clara M. Marín, María J. de Miguel, Pilar M. Muñoz, José L. Vizmanos, and Ignacio López-Goñi

Multiplex PCR Assay for the Identification and Differentiation of all Brucella Species and the Vaccine Strains Brucella abortus S19 and RB51 and Brucella melitensis Rev1
Clin Chem 2006 52: 779-781. [Extract] [Full Text] [PDF] Data Supplements  

Michelle M. Murphy, Judit Marsillach, Jordi Camps, Joan Fernández-Ballart, Bharti Mackness, Michael Mackness, Natàlia Ferré, and Jorge Joven

Influence of PON1 Polymorphisms on the Association between Serum Paraoxonase 1 and Homocysteinemia in a General Population
Clin Chem 2006 52: 781-782. [Extract] [Full Text] [PDF]  

Ulrike Haug, Moritz N. Wente, Christoph M. Seiler, Dietrich Rothenbacher, Markus W. Büchler, and Hermann Brenner

Tumor M2 Pyruvate Kinase as a Stool Marker for Colorectal Cancer: Stability at Room Temperature and Implications for Application in the Screening Setting
Clin Chem 2006 52: 782-784. [Extract] [Full Text] [PDF]  

Robert C. Hawkins

Potentially Inappropriate Repeat Laboratory Testing in Inpatients
Clin Chem 2006 52: 784-785. [Extract] [Full Text] [PDF]  

Darko Modun, Ivana Music, Visnja Katalinic, Zeljko Dujic, and Mladen Boban

Glycerol and Ethanol in Red Wine Are Responsible for Urate-Related Increases in Plasma Antioxidant Capacity
Clin Chem 2006 52: 785-787. [Extract] [Full Text] [PDF]  

Lilli B. Link and Judith S. Jacobson

Effect of Delayed Processing on High-Sensitivity C-Reactive Protein
Clin Chem 2006 52: 787-788. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Robert Rej

DORA 05-07: Directory of Rare Analyses. Jocelyn M. Hicks and Donald S. Young, editors. Washington, DC: AACC Press, 2005, 650 pp., $125.00 ($99.00 AACC members), softcover. ISBN 1-594250-31-6.
Clin Chem 2006 52: 789. [Extract] [Full Text] [PDF]  

Glen L. Hortin

The Evolution from Protein Chemistry to Proteomics: Basic Science to Clinical Application. Roger L. Lundblad. Boca Raton, FL: CRC Press, 2006, 295 pp., $139.95, hardcover. ISBN 0-8493-9678-6.
Clin Chem 2006 52: 789-790. [Extract] [Full Text] [PDF]  

Mario Plebani

Medical Biomethods Handbook. John M. Walker and Ralph Rapley. Totowa, NJ: Humana Press, 2005, 656 pp. plus CD-ROM, hardcover, $150.00. ISBN 1-58829-288-6.
Clin Chem 2006 52: 790. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

David E. Bruns

The Clinical Chemist: 2006 AACC Award Recipients
Clin Chem 2006 52: 791. [Extract] [Full Text] [PDF]  

Robin A. Felder

The Clinical Chemist: Masahide Sasaki, MD, PhD (August 27, 1933–September 23, 2005)
Clin Chem 2006 52: 791-792. [Extract] [Full Text] [PDF]  

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