Clinical Chemistry -- Table of Contents (June 1 2006, 52 [6])

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Editorials:

Luigi M. Biasucci and Vittoria Rizzello: Pregnancy-Associated Plasma Protein-A: Do Specific Markers of Vascular or Plaque Activation Exist, and Do We Really Need Them?
Clin Chem 2006 52: 913-914. [Extract] [Full Text] [PDF]

Mitchell G. Scott and David E. Bruns: Improving Training in Laboratory Medicine
Clin Chem 2006 52: 915-916. [Extract] [Full Text] [PDF]

Special Report:

Brian R. Smith, Alan Wells, C. Bruce Alexander, Edwin Bovill, Sheldon Campbell, Amitava Dasgupta, Mark Fung, Barbara Haller, John G. Howe, Curtis Parvin, Ellinor Peerschke, Henry Rinder, Steven Spitalnik, Ronald Weiss, Mark Wener for the Academy of Clinical Laboratory Physicians and Scientists: Curriculum Content and Evaluation of Resident Competency in Clinical Pathology (Laboratory Medicine): A Proposal
Clin Chem 2006 52: 917-949. Published online March 28, 2006; 10.1373/clinchem.2005.066076 [Abstract] [Full Text] [PDF]

Review:

Dorine W. Swinkels, Mirian C.H. Janssen, Jürgen Bergmans, and Joannes J.M. Marx: Hereditary Hemochromatosis: Genetic Complexity and New Diagnostic Approaches
Clin Chem 2006 52: 950-968. Published online April 20, 2006; 10.1373/clinchem.2006.068684 [Abstract] [Full Text] [PDF]

Point/Counterpoint:

Eline T. Luning Prak, Jason Park, Gordon Yu, and Irving Nachamkin: Point: Developing a Curriculum in Clinical Pathology
Clin Chem 2006 52: 969-971. Published online April 13, 2006; 10.1373/clinchem.2006.068023 [Extract] [Full Text] [PDF]

Alan Wells and Brian Smith: Counterpoint: Developing a Clinical Pathology Curriculum to Meet Current and Future Needs
Clin Chem 2006 52: 971-972. Published online April 14, 2006; 10.1373/clinchem.2006.070540 [Extract] [Full Text] [PDF]

Molecular Diagnostics and Genetics:

Francesca Bonvicini, Claudia Filippone, Elisabetta Manaresi, Giovanna Angela Gentilomi, Marialuisa Zerbini, Monica Musiani, and Giorgio Gallinella: Peptide Nucleic Acid–Based In Situ Hybridization Assay for Detection of Parvovirus B19 Nucleic Acids
Clin Chem 2006 52: 973-978. Published online March 30, 2006; 10.1373/clinchem.2005.064741 [Abstract] [Full Text] [PDF] 064741.Supp Data Tables

Eveline C. Timmermans, Pablo Tebas, Jos P.N. Ruiter, Ronald J.A. Wanders, Anthony de Ronde, and Michel P. de Baar: Real-Time Nucleic Acid Sequence–Based Amplification Assay to Quantify Changes in Mitochondrial DNA Concentrations in Cell Cultures and Blood Cells from HIV-Infected Patients Receiving Antiviral Therapy
Clin Chem 2006 52: 979-987. Published online April 6, 2006; 10.1373/clinchem.2005.062901 [Abstract] [Full Text] [PDF] 062901.Supplemental Data

Noh Jin Park, Yang Li, Tianwei Yu, Brigitta M.N. Brinkman, and David T. Wong: Characterization of RNA in Saliva
Clin Chem 2006 52: 988-994. Published online April 6, 2006; 10.1373/clinchem.2005.063206 [Abstract] [Full Text] [PDF] 063206.Supplemental Data

Loren C. Denlinger, Douglas B. Coursin, Kathleen Schell, Giuditta Angelini, Dawn N. Green, Arturo G. Guadarrama, Jennifer Halsey, Usha Prabhu, Kirk J. Hogan, and Paul J. Bertics: Human P2X₇ Pore Function Predicts Allele Linkage Disequilibrium
Clin Chem 2006 52: 995-1004. Published online April 13, 2006; 10.1373/clinchem.2005.065425 [Abstract] [Full Text] [PDF] 065425.Supplemental Data

Helen E. White, Victoria J. Durston, John F. Harvey, and Nicholas C.P. Cross: Quantitative Analysis of SRNPN Gene Methylation by Pyrosequencing as a Diagnostic Test for Prader–Willi Syndrome and Angelman Syndrome
Clin Chem 2006 52: 1005-1013. Published online March 30, 2006; 10.1373/clinchem.2005.065086 [Abstract] [Full Text] [PDF] 065086.Suppl Data

Anne Valle, Daniel T. O’Connor, Palmer Taylor, Gu Zhu, Grant W. Montgomery, P. Eline Slagboom, Nicholas G. Martin, and John B. Whitfield: Butyrylcholinesterase: Association with the Metabolic Syndrome and Identification of 2 Gene Loci Affecting Activity
Clin Chem 2006 52: 1014-1020. Published online March 30, 2006; 10.1373/clinchem.2005.065052 [Abstract] [Full Text] [PDF] 065052.Suppl data file

Sebastian Blesa, Ana Barbara Garcia-Garcia, Sergio Martinez-Hervas, Maria Luisa Mansego, Veronica Gonzalez-Albert, Juan Francisco Ascaso, Rafael Carmena, Jose Tomas Real, and Felipe Javier Chaves: Analysis of Sequence Variations in the LDL Receptor Gene in Spain: General Gene Screening or Search for Specific Alterations?
Clin Chem 2006 52: 1021-1025. Published online April 20, 2006; 10.1373/clinchem.2006.067645 [Abstract] [Full Text] [PDF]

Lori Kruse, Alice M. Mitchell, Carlos A. Camargo, Jr, Jackeline Hernandez, and Jeffrey A. Kline: Frequency of Thrombophilia-Related Genetic Variations in Patients with Idiopathic Pulmonary Embolism in an Urban Emergency Department
Clin Chem 2006 52: 1026-1032. Published online March 30, 2006; 10.1373/clinchem.2005.061861 [Abstract] [Full Text] [PDF]

Yusheng Zhu, David W. Hein, Mark A. Doll, Kristen K. Reynolds, Ntei Abudu, Roland Valdes, Jr, and Mark W. Linder: Simultaneous Determination of 7 N-Acetyltransferase-2 Single-Nucleotide Variations by Allele-Specific Primer Extension Assay
Clin Chem 2006 52: 1033-1039. Published online March 23, 2006; 10.1373/clinchem.2005.063198 [Abstract] [Full Text] [PDF] Data Supplement

Hemostasis and Thrombosis:

Georg Endler, Claudia Marsik, Bernd Jilma, Thomas Schickbauer, Rainer Vormittag, Oswald Wagner, Christine Mannhalter, Helmut Rumpold, and Ingrid Pabinger: Anti-Cardiolipin Antibodies and Overall Survival in a Large Cohort: Preliminary Report
Clin Chem 2006 52: 1040-1044. Published online March 30, 2006; 10.1373/clinchem.2005.063925 [Abstract] [Full Text] [PDF] 063925.Suppl Data Table 1

Proteomics and Protein Markers:

Jin Song, Manisha Patel, C. Nicole Rosenzweig, Yee Chan-Li, Lori J. Sokoll, Eric T. Fung, Nam-Ho Choi-Miura, Michael Goggins, Daniel W. Chan, and Zhen Zhang: Quantification of Fragments of Human Serum Inter- ${alpha}$ -Trypsin Inhibitor Heavy Chain 4 by a Surface-Enhanced Laser Desorption/Ionization-Based Immunoassay
Clin Chem 2006 52: 1045-1053. Published online March 30, 2006; 10.1373/clinchem.2005.065722 [Abstract] [Full Text] [PDF] 065722.Supplemental data

Isabelle Giuliani, François Rieunier, Catherine Larue, Jean-François Delagneau, Claude Granier, Bernard Pau, Marc Ferrière, Max Saussine, Jean-Paul Cristol, Anne-Marie Dupuy, Emmanuel Merigeon, Delphine Merle, and Sylvie Villard: Assay for Measurement of Intact B-Type Natriuretic Peptide Prohormone in Blood
Clin Chem 2006 52: 1054-1061. Published online March 30, 2006; 10.1373/clinchem.2005.061770 [Abstract] [Full Text] [PDF]

Cancer Diagnostics:

Naoyuki Umetani, Joseph Kim, Suzanne Hiramatsu, Howard A. Reber, Oscar J. Hines, Anton J. Bilchik, and Dave S. B. Hoon: Increased Integrity of Free Circulating DNA in Sera of Patients with Colorectal or Periampullary Cancer: Direct Quantitative PCR for ALU Repeats
Clin Chem 2006 52: 1062-1069. [Abstract] [Full Text] [PDF] 068577.Supplemental Data

Leon Holzscheiter, Julia C. Biermann, Matthias Kotzsch, Panagiotis Prezas, Juliane Farthmann, Gustavo Baretton, Thomas Luther, Vivianne C.G. Tjan-Heijnen, Maroulio Talieri, Manfred Schmitt, Fred C.G.J. Sweep, Paul N. Span, and Viktor Magdolen: Quantitative Reverse Transcription-PCR Assay for Detection of mRNA Encoding Full-Length Human Tissue Kallikrein 7: Prognostic Relevance of KLK7 mRNA Expression in Breast Cancer
Clin Chem 2006 52: 1070-1079. Published online April 20, 2006; 10.1373/clinchem.2005.065599 [Abstract] [Full Text] [PDF]

Ethan Fitzpatrick, Sterling McBride, Jonathan Yavelow, Saltanat Najmi, Peter Zanzucchi, and Robert Wieder: Microfluidic Techniques for Single-Cell Protein Expression Analysis
Clin Chem 2006 52: 1080-1088. Published online March 23, 2006; 10.1373/clinchem.2005.059014 [Abstract] [Full Text] [PDF] 059014.Supplemental Data

Jack Groskopf, Sheila M.J. Aubin, Ina Lim Deras, Amy Blase, Sharon Bodrug, Craig Clark, Steven Brentano, Jeannette Mathis, Jimmykim Pham, Troels Meyer, Michelle Cass, Petrea Hodge, Maria Luz Macairan, Leonard S. Marks, and Harry Rittenhouse: APTIMA PCA3 Molecular Urine Test: Development of a Method to Aid in the Diagnosis of Prostate Cancer
Clin Chem 2006 52: 1089-1095. Published online April 20, 2006; 10.1373/clinchem.2005.063289 [Abstract] [Full Text] [PDF]

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Thomas Mueller, Benjamin Dieplinger, Werner Poelz, and Meinhard Haltmayer: Increased Pregnancy-Associated Plasma Protein-A as a Marker for Peripheral Atherosclerosis: Results from the Linz Peripheral Arterial Disease Study
Clin Chem 2006 52: 1096-1103. Published online April 13, 2006; 10.1373/clinchem.2005.065763 [Abstract] [Full Text] [PDF]

Endocrinology and Metabolism:

Anne L. Mørkbak, Anne-Mette Hvas, Zouë Lloyd-Wright, Tom A.B. Sanders, Øyvind Bleie, Helga Refsum, Ottar K. Nygaard, and Ebba Nexø: Effect of Vitamin B₁₂ Treatment on Haptocorrin
Clin Chem 2006 52: 1104-1111. Published online April 13, 2006; 10.1373/clinchem.2005.061549 [Abstract] [Full Text] [PDF] 061549.Supplemental Data

Christian Bieglmayer, Klaus Kaczirek, Gerhard Prager, and Bruno Niederle: Parathyroid Hormone Monitoring during Total Parathyroidectomy for Renal Hyperparathyroidism: Pilot Study of the Impact of Renal Function and Assay Specificity
Clin Chem 2006 52: 1112-1119. Published online April 13, 2006; 10.1373/clinchem.2005.065490 [Abstract] [Full Text] [PDF]

Gary L. Lensmeyer, Donald A. Wiebe, Neil Binkley, and Marc K. Drezner: HPLC Method for 25-Hydroxyvitamin D Measurement: Comparison with Contemporary Assays
Clin Chem 2006 52: 1120-1126. Published online March 30, 2006; 10.1373/clinchem.2005.064956 [Abstract] [Full Text] [PDF]

Susen Hartmann, Jürgen G. Okun, Christiane Schmidt, Claus-Dieter Langhans, Sven F. Garbade, Peter Burgard, Dorothea Haas, Jörn Oliver Sass, William L. Nyhan, and Georg F. Hoffmann: Comprehensive Detection of Disorders of Purine and Pyrimidine Metabolism by HPLC with Electrospray Ionization Tandem Mass Spectrometry
Clin Chem 2006 52: 1127-1137. Published online April 13, 2006; 10.1373/clinchem.2005.058842 [Abstract] [Full Text] [PDF] 058842.Supplemental Data

Andrea Mosca, Renata Paleari, Maria G. Dalfrà, Graziano Di Cianni, Ilaria Cuccuru, Giovanni Pellegrini, Lucia Malloggi, Matteo Bonomo, Simona Granata, Ferruccio Ceriotti, Maria T. Castiglioni, Marco Songini, Giuliana Tocco, Michela Masin, Mario Plebani, and Annunziata Lapolla: Reference Intervals for Hemoglobin A_1c in Pregnant Women: Data from an Italian Multicenter Study
Clin Chem 2006 52: 1138-1143. Published online April 6, 2006; 10.1373/clinchem.2005.064899 [Abstract] [Full Text] [PDF]

Jana Papassotiriou, Nils G. Morgenthaler, Joachim Struck, Christine Alonso, and Andreas Bergmann: Immunoluminometric Assay for Measurement of the C-Terminal Endothelin-1 Precursor Fragment in Human Plasma
Clin Chem 2006 52: 1144-1151. Published online April 20, 2006; 10.1373/clinchem.2005.065581 [Abstract] [Full Text] [PDF]

Automation and Analytical Techniques:

Sigrun M. Gustafsdottir, Ann Nordengrahn, Simon Fredriksson, Per Wallgren, Esteban Rivera, Edith Schallmeiner, Malik Merza, and Ulf Landegren: Detection of Individual Microbial Pathogens by Proximity Ligation
Clin Chem 2006 52: 1152-1160. [Abstract] [Full Text] [PDF] 065847.Supplemental data Figure 1

Jochen Wilhelm, Jai Prakash Muyal, Johannes Best, Grazyna Kwapiszewska, Maria Magdalena Stein, Werner Seeger, Rainer Maria Bohle, and Ludger Fink: Systematic Comparison of the T7-IVT and SMART-Based RNA Preamplification Techniques for DNA Microarray Experiments
Clin Chem 2006 52: 1161-1167. Published online April 20, 2006; 10.1373/clinchem.2005.062406 [Abstract] [Full Text] [PDF] 062406.Supplemental Data

General Clinical Chemistry:

Jan H. Verheijen, Linda G.M. Huisman, Natascha van Lent, Ulf Neumann, Paolo Paganetti, C. Erik Hack, Femke Bouwman, Jan Lindeman, Edward L.E.M. Bollen, and Roeland Hanemaaijer: Detection of a Soluble Form of BACE-1 in Human Cerebrospinal Fluid by a Sensitive Activity Assay
Clin Chem 2006 52: 1168-1174. Published online April 13, 2006; 10.1373/clinchem.2006.066720 [Abstract] [Full Text] [PDF]

Clinical Immunology:

Antonio Carroccio, Lidia Di Prima, Giuseppe Pirrone, Calogero Scalici, Ada M. Florena, Maurizio Gasparin, Giuseppe Tolazzi, Antonino Gucciardi, Carmelo Sciumè, and Giuseppe Iacono: Anti-Transglutaminase Antibody Assay of the Culture Medium of Intestinal Biopsy Specimens Can Improve the Accuracy of Celiac Disease Diagnosis
Clin Chem 2006 52: 1175-1180. Published online March 30, 2006; 10.1373/clinchem.2005.061366 [Abstract] [Full Text] [PDF]

Pediatric Clinical Chemistry:

Pak C. Ng, Karen Li, Ting F. Leung, Raymond P.O. Wong, Geng Li, Kit M. Chui, Eric Wong, Frankie W.T. Cheng, and Tai F. Fok: Early Prediction of Sepsis-Induced Disseminated Intravascular Coagulation with Interleukin-10, Interleukin-6, and RANTES in Preterm Infants
Clin Chem 2006 52: 1181-1189. Published online April 13, 2006; 10.1373/clinchem.2005.062075 [Abstract] [Full Text] [PDF] 062075.Supplemental Data

Technical Briefs:

Marion Funk, Georg Endler, Wolfgang Lalouschek, Kety Hsieh, Martin Schillinger, Wilfried Lang, and Christine Mannhalter: Factor VII Gene Haplotypes and Risk of Ischemic Stroke
Clin Chem 2006 52: 1190-1192. Published online March 23, 2006; 10.1373/clinchem.2005.059360 [Abstract] [Full Text] [PDF] 059360.Suppl Data Table 1

Diego Rodríguez Cabaleiro, Dietmar Stöckl, Jean M. Kaufman, Tom Fiers, and Linda M. Thienpont: Feasibility of Standardization of Serum C-Peptide Immunoassays with Isotope-Dilution Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2006 52: 1193-1196. Published online April 13, 2006; 10.1373/clinchem.2005.062505 [Abstract] [Full Text] [PDF] 062505.Supplemental data

Adrienne C.M. Persoon, Thera P. Links, Juergen Wilde, Wim J. Sluiter, Bruce H.R. Wolffenbuttel, and Johannes M.W. van den Ouweland: Thyroglobulin (Tg) Recovery Testing with Quantitative Tg Antibody Measurement for Determining Interference in Serum Tg Assays in Differentiated Thyroid Carcinoma
Clin Chem 2006 52: 1196-1199. Published online March 30, 2006; 10.1373/clinchem.2005.060103 [Abstract] [Full Text] [PDF] 060103.Supplemental Data

Letters to the Editor:

Gabriella Doronzo, Isabella Russo, Mariella Trovati, and Giovanni Anfossi: Sodium Azide in Commercially Available C-Reactive Protein Preparations Does Not Influence Matrix Metalloproteinase-2 Synthesis and Release in Cultured Human Aortic Vascular Smooth Muscle Cells
Clin Chem 2006 52: 1200-1201. [Extract] [Full Text] [PDF]

Christiana Winkler, Florian Ueberall, and Dietmar Fuchs: In Vitro Testing for Antiinflammatory Properties of Compounds
Clin Chem 2006 52: 1201-1202. [Extract] [Full Text] [PDF]

Ronald T.K. Pang, Terence C.W. Poon, K.C. Allen Chan, Nelson L.S. Lee, Rossa W.K. Chiu, Yu-Kwan Tong, Stephen S.C. Chim, Joseph J.Y. Sung, and Y.M. Dennis Lo: Serum Amyloid A Is Not Useful in the Diagnosis of Severe Acute Respiratory Syndrome
Clin Chem 2006 52: 1202-1204. [Extract] [Full Text] [PDF]

Jan S. Krouwer: Uncertainty Intervals Based on Deleting Data Are Not Useful
Clin Chem 2006 52: 1204-1205. [Extract] [Full Text] [PDF]

Wayne Dimech: Uncertainty Intervals Based on Deleting Data Are Not Useful: Reply
Clin Chem 2006 52: 1205. [Extract] [Full Text] [PDF]

Jonathan Golledge, Leonie Jones, Lisa Oliver, Francis Quigley, and Mirko Karan: Folic Acid, Vitamin B₁₂, MTHFR Genotypes, and Plasma Homocysteine
Clin Chem 2006 52: 1205-1206. [Extract] [Full Text] [PDF]

Per M. Humpert, Marco J. Battista, Alexander Lammert, Peter Reismann, Zdenka Djuric, Gottfried Rudofsky, Jr, Markus Zorn, Michael Morcos, Hans-Peter Hammes, Peter P. Nawroth, and Angelika Bierhaus: Association of Stromal Cell–Derived Factor 1 Genotype with Diabetic Foot Syndrome and Macrovascular Disease in Patients with Type 2 Diabetes
Clin Chem 2006 52: 1206-1208. [Extract] [Full Text] [PDF]

Ashish A. Sule and Melvin Khee Shing Leow: Association of Polycystic Ovary Syndrome and Fibromyalgia in a Patient with Primary Hyperparathyroidism: A Novel Triad?
Clin Chem 2006 52: 1208-1209. [Extract] [Full Text] [PDF]

Anargyros Kourtis, David Rousso, Christos Balaris, Dimitrios Farmakiotis, Ilias Katsikis, and Dimitrios Panidis: Association of Polycystic Ovary Syndrome and Fibromyalgia in a Patient with Primary Hyperparathyroidism: A Novel Triad? - Reply
Clin Chem 2006 52: 1209-1210. [Extract] [Full Text] [PDF]

Akira Ueda, Noriaki Kume, Kazutaka Hayashida, Atsuko Inui-Hayashida, Mika Asai, Toru Kita, and Goro Kominami: ELISA for Soluble Form of Lectin-Like Oxidized LDL Receptor-1, A Novel Marker of Acute Coronary Syndrome
Clin Chem 2006 52: 1210-1211. [Extract] [Full Text] [PDF]

Alexis E. Malavazos, Lelio Morricone, Alessandro Marocchi, Federica Ermetici, Bruno Ambrosi, and Massimiliano M. Corsi: N-Terminal Pro-B-Type Natriuretic Peptide and Echocardiographic Abnormalities in Severely Obese Patients: Correlation with Visceral Fat
Clin Chem 2006 52: 1211-1213. [Extract] [Full Text] [PDF]

Corrections:

: Correction
Clin Chem 2006 52: 1213. [Extract] [Full Text] [PDF]

Book, Software, and Web Site Reviews:

Klaus Jung: Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Fourth Edition. Carl A. Burtis, Edward R. Ashwood, and David E. Bruns, editors. St. Louis, MO: Elsevier Saunders, 2006, 2448 pp., $229.00, hardcover. ISBN 0-7216-0189-8.
Clin Chem 2006 52: 1214. Published online April 13, 2006; 10.1373/clinchem.2005.062638 [Extract] [Full Text] [PDF]

Sridar V. Chittur: Methods in Molecular Medicine: Microarrays in Clinical Diagnostics. Thomas O. Joos and Paolo Fortina, editors. Totowa, NJ: Humana Press, 2005, 288 pp., $121.50, hardcover. ISBN 1-58829-394-7.
Clin Chem 2006 52: 1215. [Extract] [Full Text] [PDF]

Donald Rej: Lab Dynamics: Management Skills for Scientists. Carl M. Cohen and Suzanne L. Cohen. Woodbury, NY: Cold Spring Harbor Laboratory Press, 2005, 176 pp., $59.00, hardcover. ISBN 0-87969-741-5.
Clin Chem 2006 52: 1215-1216. [Extract] [Full Text] [PDF]