Overview:

Corné Biesheuvel, Les Irwig, and Patrick Bossuyt

Observed Differences in Diagnostic Test Accuracy between Patient Subgroups: Is It Real or Due to Reference Standard Misclassification?
Clin Chem 2007 53: 1725-1729. [Abstract] [Full Text] [PDF] 087403.Supplemental Data  

Opinion:

Xavier Bossuyt, Kurt Verweire, and Norbert Blanckaert

Laboratory Medicine: Challenges and Opportunities
Clin Chem 2007 53: 1730-1733. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Ralf Zarbock, Doris Hendig, Christiane Szliska, Knut Kleesiek, and Christian Götting

Pseudoxanthoma Elasticum: Genetic Variations in Antioxidant Genes Are Risk Factors for Early Disease Onset
Clin Chem 2007 53: 1734-1740. Published online August 10, 2007; 10.1373/clinchem.2007.088211 [Abstract] [Full Text] [PDF]  

Qiuying Huang, Qinghua Hu, and Qingge Li

Identification of 8 Foodborne Pathogens by Multicolor Combinational Probe Coding Technology in a Single Real-Time PCR
Clin Chem 2007 53: 1741-1748. Published online August 10, 2007; 10.1373/clinchem.2007.087502 [Abstract] [Full Text] [PDF] 087502.Supplemental Data  

Kathryn M. Rexrode, Paul M. Ridker, Hillary H. Hegener, Julie E. Buring, JoAnn E. Manson, and Robert Y.L. Zee

Polymorphisms and Haplotypes of the Estrogen Receptor-ß Gene (ESR2) and Cardiovascular Disease in Men and Women
Clin Chem 2007 53: 1749-1756. Published online August 16, 2007; 10.1373/clinchem.2007.091454 [Abstract] [Full Text] [PDF]  

Basile Stamatopoulos, Nathalie Meuleman, Benjamin Haibe-Kains, Hughes Duvillier, Martine Massy, Philippe Martiat, Dominique Bron, and Laurence Lagneaux

Quantification of ZAP70 mRNA in B Cells by Real-Time PCR Is a Powerful Prognostic Factor in Chronic Lymphocytic Leukemia
Clin Chem 2007 53: 1757-1766. Published online August 16, 2007; 10.1373/clinchem.2007.089326 [Abstract] [Full Text] [PDF] 089326.Supplemental Data  

Stefania Stenirri, Gabriella Restagno, Giovanni Battista Ferrero, Georgia Alaimo, Luca Sbaiz, Caterina Mari, Lorenzo Genitori, Ferrari Maurizio, and Laura Cremonesi

Integrated Strategy for Fast and Automated Molecular Characterization of Genes Involved in Craniosynostosis
Clin Chem 2007 53: 1767-1774. Published online August 10, 2007; 10.1373/clinchem.2007.089292 [Abstract] [Full Text] [PDF] 089292.Supplemental Data  

Evidence-Based Laboratory Medicine and Test Utilization:

Kelly E. McGowan, Martha E. Lyon, Steven D. Loken, and J. Decker Butzner

Celiac Disease: Are Endomysial Antibody Test Results Being Used Appropriately?
Clin Chem 2007 53: 1775-1781. Published online August 10, 2007; 10.1373/clinchem.2007.090308 [Abstract] [Full Text] [PDF] 090308.Supplemental Data  

Proteomics and Protein Markers:

Brendan J. McMorran, Severine A. Ouvry Patat, John B. Carlin, Keith Grimwood, Alun Jones, David S. Armstrong, John C. Galati, Peter J. Cooper, Catherine A. Byrnes, Paul W. Francis, Colin F. Robertson, David A. Hume, Christoph H. Borchers, Claire E. Wainwright, and Brandon J. Wainwright

Novel Neutrophil-Derived Proteins in Bronchoalveolar Lavage Fluid Indicate an Exaggerated Inflammatory Response in Pediatric Cystic Fibrosis Patients
Clin Chem 2007 53: 1782-1791. Published online August 16, 2007; 10.1373/clinchem.2007.087650 [Abstract] [Full Text] [PDF] 087650.Supplemental Data  

Bevin Gangadharan, Robin Antrobus, Raymond A. Dwek, and Nicole Zitzmann

Novel Serum Biomarker Candidates for Liver Fibrosis in Hepatitis C Patients
Clin Chem 2007 53: 1792-1799. Published online August 16, 2007; 10.1373/clinchem.2007.089144 [Abstract] [Full Text] [PDF] 089144.Supplemental Data  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Benjamin M. Scirica, David A. Morrow, Christopher P. Cannon, James A. de Lemos, Sabina Murphy, Marc S. Sabatine, Stephen D. Wiviott, Nader Rifai, Carolyn H. McCabe, Eugene Braunwald for the Thrombolysis in Myocardial Infarction (TIMI) Study Group

Clinical Application of C-Reactive Protein Across the Spectrum of Acute Coronary Syndromes
Clin Chem 2007 53: 1800-1807. Published online August 23, 2007; 10.1373/clinchem.2007.087957 [Abstract] [Full Text] [PDF]  

Sylvain Clauser, Séverine Peyrard, Pascale Gaussem, Malvina Crespin, Joseph Emmerich, Martine Aiach, and Delphine Borgel

Development of a Novel Immunoassay for the Assessment of Plasma Gas6 Concentrations and Their Variation with Hormonal Status
Clin Chem 2007 53: 1808-1813. Published online August 23, 2007; 10.1373/clinchem.2007.089102 [Abstract] [Full Text] [PDF]  

William E. Alborn, Guoqing Cao, Holly E. Careskey, Yue-Wei Qian, Danise R. Subramaniam, Julian Davies, Elaine M. Conner, and Robert J. Konrad

Serum Proprotein Convertase Subtilisin Kexin Type 9 Is Correlated Directly with Serum LDL Cholesterol
Clin Chem 2007 53: 1814-1819. Published online August 16, 2007; 10.1373/clinchem.2007.091280 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Graham J. Worsley, Guilhem A. Tourniaire, Kathryn E. S. Medlock, Felicity K. Sartain, Hazel E. Harmer, Michael Thatcher, Adrian M. Horgan, and John Pritchard

Continuous Blood Glucose Monitoring with a Thin-Film Optical Sensor
Clin Chem 2007 53: 1820-1826. Published online August 23, 2007; 10.1373/clinchem.2007.091629 [Abstract] [Full Text] [PDF] 091629.Supplemental Data  

Thomas M. Annesley

Methanol-Associated Matrix Effects in Electrospray Ionization Tandem Mass Spectrometry
Clin Chem 2007 53: 1827-1834. Published online August 16, 2007; 10.1373/clinchem.2007.090811 [Abstract] [Full Text] [PDF] 090811.Supplemental Data  

General Clinical Chemistry:

Pascal Lim, Jean-Phillipe Collet, Stéphane Moutereau, Nathalie Guigui, Laurens Mitchell-Heggs, Sylvain Loric, Magy Bernard, Said Benhamed, Gilles Montalescot, Jean-Luc Dubois Randé, and Pascal Guéret

Fetuin-A Is an Independent Predictor of Death after ST-Elevation Myocardial Infarction
Clin Chem 2007 53: 1835-1840. Published online August 16, 2007; 10.1373/clinchem.2006.084947 [Abstract] [Full Text] [PDF] 084947.Supplemental Data  

Nutrition:

Grainne M. Connolly, Ronan Cunningham, A. Peter Maxwell, and Ian S. Young

Decreased Serum Retinol Is Associated with Increased Mortality in Renal Transplant Recipients
Clin Chem 2007 53: 1841-1846. Published online August 23, 2007; 10.1373/clinchem.2006.084699 [Abstract] [Full Text] [PDF]  

Infectious Disease:

Shale Dames, David C. Pattison, L. Kathryn Bromley, Carl T. Wittwer, and Karl V. Voelkerding

Unlabeled Probes for the Detection and Typing of Herpes Simplex Virus
Clin Chem 2007 53: 1847-1854. Published online August 24, 2007; 10.1373/clinchem.2007.090761 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Anders Helander, Ingrid Olsson, and Helen Dahl

Postcollection Synthesis of Ethyl Glucuronide by Bacteria in Urine May Cause False Identification of Alcohol Consumption
Clin Chem 2007 53: 1855-1857. Published online August 23, 2007; 10.1373/clinchem.2007.089482 [Abstract] [Full Text] [PDF]  

Janine Hartweg, Michael Gunter, Rafael Perera, Andrew Farmer, Carole Cull, Casper Schalkwijk, Astrid Kok, Harry Twaalfhoven, Rury Holman, and Andrew Neil

Stability of Soluble Adhesion Molecules, Selectins, and C-Reactive Protein at Various Temperatures: Implications for Epidemiological and Large-Scale Clinical Studies
Clin Chem 2007 53: 1858-1860. Published online August 3, 2007; 10.1373/clinchem.2006.076380 [Abstract] [Full Text] [PDF] 076380.Supplemental Data  

Manuel Collado, Vanesa Garcia, Jose Miguel Garcia, Isabel Alonso, Luis Lombardia, Ramon Diaz-Uriarte, Luis A. López Fernández, Angel Zaballos, Félix Bonilla, and Manuel Serrano

Genomic Profiling of Circulating Plasma RNA for the Analysis of Cancer
Clin Chem 2007 53: 1860-1863. Published online August 23, 2007; 10.1373/clinchem.2007.089201 [Abstract] [Full Text] [PDF] 089201.Supplemental Data  

Letters to the Editor:

Peter Findeisen, Stefan Post, Frederik Wenz, and Michael Neumaier

Addition of Exogenous Reporter Peptides to Serum Samples before Mass Spectrometry-Based Protease Profiling Provides Advantages over Profiling of Endogenous Peptides
Clin Chem 2007 53: 1864-1866. [Extract] [Full Text] [PDF]  

Giuseppe Lippi, Giovanni Targher, and Gian Cesare Guidi

Relationship between -Glutamyltransferase, Fasting Plasma Glucose, and Triglycerides in the General Population
Clin Chem 2007 53: 1866-1867. [Extract] [Full Text] [PDF]  

Giovanni Targher, Giacomo Zoppini, Giuseppe Lippi, Gian Cesare Guidi, and Michele Muggeo

Effect of Serum Gamma-Glutamyltransferase and Obesity on the Risk of Dyslipidemia and Poor Glycemic Control in Type 2 Diabetic Patients: Cross-Sectional Findings from the Verona Diabetes Study
Clin Chem 2007 53: 1867-1869. [Extract] [Full Text] [PDF]  

Duk-Hee Lee, Ji-Sun Lim, and David R. Jacobs, Jr

The authors of the article cited above respond:
Clin Chem 2007 53: 1869-1870. [Extract] [Full Text] [PDF]  

Thomas Remer and Christiane Maser-Gluth

Simultaneous Measurements of Urinary Free Cortisol and Cortisone for the Assessment of Functional Glucocorticoid Activity
Clin Chem 2007 53: 1870-1871. [Extract] [Full Text] [PDF]  

Luca Giovanella and Antonella Ghelfo

Undetectable Serum Thyroglobulin Due to Negative Interference of Heterophile Antibodies in Relapsing Thyroid Carcinoma
Clin Chem 2007 53: 1871-1872. [Extract] [Full Text] [PDF]  

Mario Plebani

Laboratory Medicine: Value for Patients Is the Goal
Clin Chem 2007 53: 1873-1874. [Extract] [Full Text] [PDF]  

Samuel I. Stolper, Sonny S. Mark, Jason Y. Park, and Larry J. Kricka

Nanotechnology and Immunoassay
Clin Chem 2007 53: 1874. [Extract] [Full Text] [PDF] Database  

Rebecca Wing Yan Chan, Colin A. Graham, Timothy H. Rainer, Nicole Yuk Lan Lam, Rossa Wai Kwun Chiu, Ki-Wai Chik, Vincent Lee, and Yuk Ming Dennis Lo

Use of a Bone Marrow Transplantation Model System to Demonstrate the Hematopoietic Origin of Plasma S100B mRNA
Clin Chem 2007 53: 1874-1876. [Extract] [Full Text] [PDF]  

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