Editorials:

Michael J. Bennett

Untargeted Metabolomic Analysis Hits the Target
Clin Chem 2007 53: 2037-2039. [Extract] [Full Text] [PDF]  

Opinion:

Raymond Gambino

Glucose: A Simple Molecule That Is Not Simple to Quantify
Clin Chem 2007 53: 2040-2041. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Brent C. Satterfield, David A. Kulesh, David A. Norwood, Leonard P. Wasieloski, Jr, Michael R. Caplan, and Jay A.A. West

Tentacle Probes^TM: Differentiation of Difficult Single-Nucleotide Polymorphisms and Deletions by Presence or Absence of a Signal in Real-Time PCR
Clin Chem 2007 53: 2042-2050. Published online October 11, 2007; 10.1373/clinchem.2007.091488 [Abstract] [Full Text] [PDF]  

Yiping Shen, David T. Miller, Sau Wai Cheung, Va Lip, Xiaoming Sheng, Keith Tomaszewicz, Hong Shao, Hong Fang, Hung Siv Tang, Mira Irons, Christopher A. Walsh, Orah Platt, James F. Gusella, and Bai-Lin Wu

Development of a Focused Oligonucleotide-Array Comparative Genomic Hybridization Chip for Clinical Diagnosis of Genomic Imbalance
Clin Chem 2007 53: 2051-2059. Published online September 27, 2007; 10.1373/clinchem.2007.090290 [Abstract] [Full Text] [PDF] 090290.Data Supplement  

Séverine Cunat, Muriel Giansily-Blaizot, Michael Bismuth, François Blanc, Olivier Dereure, Dominique Larrey, Alain Le Quellec, Philippe Pouderoux, Christian Rose, Isabelle Raingeard, Eric Renard, Jean-François Schved, Patricia Aguilar-Martinez the CHU Montpellier AOI 2004 Working Group

Global Sequencing Approach for Characterizing the Molecular Background of Hereditary Iron Disorders
Clin Chem 2007 53: 2060-2069. Published online October 19, 2007; 10.1373/clinchem.2007.090605 [Abstract] [Full Text] [PDF] Supplemental Data Original Tables 1 & 2  

Merle Hanke, Ingo Kausch, Gerlinde Dahmen, Dieter Jocham, and Jens M. Warnecke

Detailed Technical Analysis of Urine RNA-Based Tumor Diagnostics Reveals ETS2/Urokinase Plasminogen Activator to Be a Novel Marker for Bladder Cancer
Clin Chem 2007 53: 2070-2077. Published online October 5, 2007; 10.1373/clinchem.2007.091363 [Abstract] [Full Text] [PDF] 091363.Supplemental Data  

Simon R. Thompson, Pamela A. McCaskie, John P. Beilby, Joseph Hung, Michelle Jennens, Caroline Chapman, Peter Thompson, and Steve E. Humphries

IL18 Haplotypes Are Associated with Serum IL-18 Concentrations in a Population-Based Study and a Cohort of Individuals with Premature Coronary Heart Disease
Clin Chem 2007 53: 2078-2085. Published online October 25, 2007; 10.1373/clinchem.2007.092692 [Abstract] [Full Text] [PDF] 092692.Supplemental Data  

Evidence-Based Laboratory Medicine and Test Utilization:

NACB WRITING GROUP MEMBERS, Alan H.B. Wu, Allan S. Jaffe, Fred S. Apple, Robert L. Jesse, Gary L. Francis, David A. Morrow, L. Kristin Newby, Jan Ravkilde, W.H. Wilson Tang, Robert H. Christenson, NACB COMMITTEE MEMBERS, Robert H. Christenson, Fred S. Apple, Christopher P. Cannon, Gary L. Francis, Robert L. Jesse, David A. Morrow, L. Kristin Newby, Jan Ravkilde, Alan B. Storrow, W.H. Wilson Tang, and Alan H.B. Wu

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Use of Cardiac Troponin and B-Type Natriuretic Peptide or N-Terminal proB-Type Natriuretic Peptide for Etiologies Other than Acute Coronary Syndromes and Heart Failure
Clin Chem 2007 53: 2086-2096. Published online October 22, 2007; 10.1373/clinchem.2007.095679 [Abstract] [Full Text] [PDF]  

Marta Codognotto, Antonio Piccoli, Martina Zaninotto, Monica Mion, Mario Plebani, Ugo Vertolli, Francesco Tona, Luisa Ruzza, Agata Barchita, and Giovanni M. Boffa

Renal Dysfunction Is a Confounder for Plasma Natriuretic Peptides in Detecting Heart Dysfunction in Uremic and Idiopathic Dilated Cardiomyopathies
Clin Chem 2007 53: 2097-2104. Published online October 12, 2007; 10.1373/clinchem.2007.089656 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

David Schmidt and Stephen O. Brennan

Modified Form of the Fibrinogen Bß Chain (des-Gln Bß), a Potential Long-Lived Marker of Pancreatitis
Clin Chem 2007 53: 2105-2111. Published online October 5, 2007; 10.1373/clinchem.2007.093179 [Abstract] [Full Text] [PDF]  

Peter A. Kavsak, Dennis T. Ko, Alice M. Newman, Glenn E. Palomaki, Viliam Lustig, Andrew R. MacRae, and Allan S. Jaffe

Risk Stratification for Heart Failure and Death in an Acute Coronary Syndrome Population Using Inflammatory Cytokines and N-Terminal Pro-Brain Natriuretic Peptide
Clin Chem 2007 53: 2112-2118. Published online October 11, 2007; 10.1373/clinchem.2007.090613 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Cinzia Bonanno, Erlet Shehi, Daniel Adlerstein, and G. Mike Makrigiorgos

MS-FLAG, a Novel Real-Time Signal Generation Method for Methylation-Specific PCR
Clin Chem 2007 53: 2119-2127. Published online October 25, 2007; 10.1373/clinchem.2007.094011 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Kazuhito Miyauchi, Norihiko Kayahara, Masato Ishigami, Hideyuki Kuwata, Hideharu Mori, Hiroyuki Sugiuchi, Tetsumi Irie, Akira Tanaka, Shizuya Yamashita, and Taku Yamamura

Development of a Homogeneous Assay to Measure Remnant Lipoprotein Cholesterol
Clin Chem 2007 53: 2128-2135. Published online September 27, 2007; 10.1373/clinchem.2007.092296 [Abstract] [Full Text] [PDF] 092296.Supplemental Data  

Drug Monitoring and Toxicology:

Robert S. Goodwin, Diana G. Wilkins, Olga Averin, Robin E. Choo, Jennifer R. Schroeder, Donald R. Jasinski, Rolley E. Johnson, Hendrée E. Jones, and Marilyn A. Huestis

Buprenorphine and Norbuprenorphine in Hair of Pregnant Women and Their Infants after Controlled Buprenorphine Administration
Clin Chem 2007 53: 2136-2143. Published online October 5, 2007; 10.1373/clinchem.2007.091413 [Abstract] [Full Text] [PDF] 091413.Supplemental Data  

Endocrinology and Metabolism:

Madhur K. Sinha, Traci Songer, Qiang Xiao, John H. Sloan, Jin Wang, Shaoquen Ji, William E. Alborn, Randy A. Davis, Michael M. Swarbrick, Kimber L. Stanhope, Bruce M. Wolfe, Peter J. Havel, Todd Schraw, Robert J. Konrad, Philipp E. Scherer, and Jehangir S. Mistry

Analytical Validation and Biological Evaluation of a High–Molecular-Weight Adiponectin ELISA
Clin Chem 2007 53: 2144-2151. Published online October 19, 2007; 10.1373/clinchem.2007.090670 [Abstract] [Full Text] [PDF]  

Yuan-Xiang Meng, Earl S. Ford, Chaoyang Li, Alexander Quarshie, Ahmad M. Al-Mahmoud, Wayne Giles, Gary H. Gibbons, and Gregory Strayhorn

Association of C-Reactive Protein with Surrogate Measures of Insulin Resistance among Nondiabetic US Adults: Findings from National Health and Nutrition Examination Survey 1999–2002
Clin Chem 2007 53: 2152-2159. Published online October 19, 2007; 10.1373/clinchem.2007.088930 [Abstract] [Full Text] [PDF]  

Frank Giton, Saïk Urien, Catherine Born, Jean Tichet, Jérôme Guéchot, Jacques Callebert, Françoise Bronsard, Jean Pierre Raynaud, and Jean Fiet

Determination of Bioavailable Testosterone [Non–Sex Hormone–Binding Globulin (SHBG)-Bound Testosterone] in a Population of Healthy French Men: Influence of Androstenediol on Testosterone Binding to SHBG
Clin Chem 2007 53: 2160-2168. Published online October 11, 2007; 10.1373/clinchem.2007.087312 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

William R. Wikoff, Jon A. Gangoiti, Bruce A. Barshop, and Gary Siuzdak

Metabolomics Identifies Perturbations in Human Disorders of Propionate Metabolism
Clin Chem 2007 53: 2169-2176. Published online October 19, 2007; 10.1373/clinchem.2007.089011 [Abstract] [Full Text] [PDF] 089011.Supplemental Data  

Er-Qun Song, Guo-Ping Wang, Hai-Yan Xie, Zhi-Ling Zhang, Jun Hu, Jun Peng, Dao-Cheng Wu, Yun-Bo Shi, and Dai-Wen Pang

Visual Recognition and Efficient Isolation of Apoptotic Cells with Fluorescent-Magnetic-Biotargeting Multifunctional Nanospheres
Clin Chem 2007 53: 2177-2185. Published online October 25, 2007; 10.1373/clinchem.2007.092023 [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Sonia Niveloni, Emilia Sugai, Ana Cabanne, Horacio Vazquez, Julio Argonz, Edgardo Smecuol, María L. Moreno, Fabio Nachman, Roberto Mazure, Zulema Kogan, Juan C. Gomez, Eduardo Mauriño, and Julio C. Bai

Antibodies against Synthetic Deamidated Gliadin Peptides as Predictors of Celiac Disease: Prospective Assessment in an Adult Population with a High Pretest Probability of Disease
Clin Chem 2007 53: 2186-2192. Published online September 27, 2007; 10.1373/clinchem.2006.081364 [Abstract] [Full Text] [PDF]  

Infectious Disease:

Mar Masiá, Jana Papassotiriou, Nils G. Morgenthaler, Ildefonso Hernández, Conrado Shum, and Félix Gutiérrez

Midregional Pro-A-Type Natriuretic Peptide and Carboxy-Terminal Provasopressin May Predict Prognosis in Community-Acquired Pneumonia
Clin Chem 2007 53: 2193-2201. Published online October 19, 2007; 10.1373/clinchem.2007.085688 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Seung-Tae Lee, Cas W. Weykamp, Yong-Wha Lee, Jong-Won Kim, and Chang-Seok Ki

Effects of 7 Hemoglobin Variants on the Measurement of Glycohemoglobin by 14 Analytical Methods
Clin Chem 2007 53: 2202-2205. Published online October 5, 2007; 10.1373/clinchem.2007.093963 [Abstract] [Full Text] [PDF] 093963.Supplemental Data  

Jason C.H. Tsang, Pimlak Charoenkwan, Katherine C.K. Chow, Yongjie Jin, Chanane Wanapirak, Torpong Sanguansermsri, Y.M. Dennis Lo, and Rossa W.K. Chiu

Mass Spectrometry–Based Detection of Hemoglobin E Mutation by Allele-Specific Base Extension Reaction
Clin Chem 2007 53: 2205-2209. Published online October 19, 2007; 10.1373/clinchem.2007.095133 [Abstract] [Full Text] [PDF] 095133.Supplemental Data  

Charles D. Hawker, William L. Roberts, Antonio DaSilva, Gordon D. Stam, William E. Owen, DeVirl Curtis, Byung-Sang Choi, and Terry A. Ring

Development and Validation of an Automated Thawing and Mixing Workcell
Clin Chem 2007 53: 2209-2211. Published online September 21, 2007; 10.1373/clinchem.2007.094185 [Abstract] [Full Text] [PDF] 094185.Supplemental Data  

Andrew D. Laurie, Mark P. Smith, and Peter M. George

Detection of Factor VIII Gene Mutations by High-Resolution Melting Analysis
Clin Chem 2007 53: 2211-2214. Published online September 27, 2007; 10.1373/clinchem.2007.093781 [Abstract] [Full Text] [PDF] 093781.Supplemental Data  

Letters to the Editor:

Maniesh van der Vaart and Piet J. Pretorius

The Origin of Circulating Free DNA
Clin Chem 2007 53: 2215. [Extract] [Full Text] [PDF]  

Jan Terje Andersen and Inger Sandlie

A Receptor-Mediated Mechanism to Support Clinical Observation of Altered Albumin Variants
Clin Chem 2007 53: 2216. [Extract] [Full Text] [PDF]  

Ulrich Hübner, Heike Schorr, Rudolf Eckert, Jürgen Geisel, and Wolfgang Herrmann

Stability of Plasma Homocysteine, S-Adenosylmethionine, and S-Adenosylhomocysteine in EDTA, Acidic Citrate, and Primavette^TM Collection Tubes
Clin Chem 2007 53: 2217-2218. [Extract] [Full Text] [PDF]  

Alastair Matheson

From Syndrome to Spectrum: What Evolution Suggests about the Status of the Metabolic Syndrome
Clin Chem 2007 53: 2218-2219. [Extract] [Full Text] [PDF]  

Arend Bökenkamp, Cèleste A.R.C. Laarman, Katja I. Braam, Joanna A.E. van Wijk, Wijnanda A. Kors, Marijke Kool, Janneke de Valk, Anna A. Bouman, Marieke D. Spreeuwenberg, and Birgit Stoffel-Wagner

Effect of Corticosteroid Therapy on Low-Molecular–Weight Protein Markers of Kidney Function
Clin Chem 2007 53: 2219-2221. [Extract] [Full Text] [PDF]  

Giorgio Cevasco, Anna Maria Mumot, Carlo Scapolla, and Sergio Thea

Ammonium 5-Bromo-7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate: A New Fluorogenic Reagent for the Determination of Aminothiols by HPLC
Clin Chem 2007 53: 2221-2222. [Extract] [Full Text] [PDF]  

Attie T.J.I. Go, Allerdien Visser, Monique A.M. Mulders, Marinus A. Blankenstein, John M.G. van Vugt, and Cees B.M. Oudejans

44 Single-Nucleotide Polymorphisms Expressed by Placental RNA: Assessment for Use in Noninvasive Prenatal Diagnosis of Trisomy 21
Clin Chem 2007 53: 2223-2224. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Klaus Jung

Tietz’s Applied Laboratory Medicine, 2nd ed. Mitchell G. Scott, Ann M. Gronowski, and Charles S. Eby, eds. Hoboken, NJ: Wiley-Interscience, a John Wiley & Sons, Inc. Publication, 2007, 679 pp., $69.95, paperback. ISBN 978-0-471-71457-6.
Clin Chem 2007 53: 2225. [Extract] [Full Text] [PDF]  

Corrections:

Correction
Clin Chem 2007 53: 2226. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

David E. Bruns

The Clinical Chemist
Clin Chem 2007 53: 2227-2228. [Extract] [Full Text] [PDF]  

Invited Reviewers:

Invited Reviewers—2007
Clin Chem 2007 53: 2229-2232. [Extract] [Full Text] [PDF]  

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