Editorials:

Lone Schejbel and Peter Garred

Primary Immunodeficiency: Complex Genetic Disorders?
Clin Chem 2007 53: 159-160. [Extract] [Full Text] [PDF]  

Jan T. Kielstein and John P. Cooke

Should We Measure Asymmetric Dimethylarginine in Patients with Coronary Artery Disease?
Clin Chem 2007 53: 161-163. [Extract] [Full Text] [PDF]  

Review:

Mariska Leeflang, Johannes Reitsma, Rob Scholten, Anne Rutjes, Marcello Di Nisio, Jon Deeks, and Patrick Bossuyt

Impact of Adjustment for Quality on Results of Metaanalyses of Diagnostic Accuracy
Clin Chem 2007 53: 164-172. Published online December 21, 2006; 10.1373/clinchem.2006.076398 [Abstract] [Full Text] [PDF] 076398.Supplemental Data  

Molecular Diagnostics and Genetics:

Sherry Sze Yee Ho, Samuel S. Chong, Evelyn S.C. Koay, Yiong Huak Chan, Ponnusamy Sukumar, Lily-Lily Chiu, Wen Wang, Ashim Roy, Mary Rauff, Lin Lin Su, Arijit Biswas, and Mahesh Choolani

Microsatellite Markers within ^—SEA Breakpoints for Prenatal Diagnosis of HbBarts Hydrops Fetalis
Clin Chem 2007 53: 173-179. Published online December 7, 2006; 10.1373/clinchem.2006.075085 [Abstract] [Full Text] [PDF] 075085.Supplemental Data  

Suzan Wopereis, Stephanie Grünewald, Karin M.L.C. Huijben, Éva Morava, Rosella Mollicone, Baziel G.M. van Engelen, Dirk J. Lefeber, and Ron A. Wevers

Transferrin and Apolipoprotein C-III Isofocusing Are Complementary in the Diagnosis of N- and O-Glycan Biosynthesis Defects
Clin Chem 2007 53: 180-187. Published online December 14, 2006; 10.1373/clinchem.2006.073940 [Abstract] [Full Text] [PDF] 073940.Supplemental Data  

Quanjun Liu, Yunfei Bai, Qinyu Ge, Shixin Zhou, Tian Wen, and Zuhong Lu

Microarray-in-a-Tube for Detection of Multiple Viruses
Clin Chem 2007 53: 188-194. Published online December 7, 2006; 10.1373/clinchem.2006.071720 [Abstract] [Full Text] [PDF] 071720.Supplemental Data  

Yun Jiang, Thomas A. Hall, Steven A. Hofstadler, and Robert K. Naviaux

Mitochondrial DNA Mutation Detection by Electrospray Mass Spectrometry
Clin Chem 2007 53: 195-203. Published online December 7, 2006; 10.1373/clinchem.2006.074823 [Abstract] [Full Text] [PDF] 074823.Supplemental data  

Femke Van Bockstaele, Valerie Pede, Ann Janssens, Filip Callewaert, Fritz Offner, Bruno Verhasselt, and Jan Philippé

Lipoprotein Lipase mRNA Expression in Whole Blood Is a Prognostic Marker in B Cell Chronic Lymphocytic Leukemia
Clin Chem 2007 53: 204-212. Published online December 7, 2006; 10.1373/clinchem.2006.076331 [Abstract] [Full Text] [PDF]  

Evidence-Based Laboratory Medicine and Test Utilization:

Marten J. Poley, Kyra I. Edelenbos, Mees Mosseveld, Marc A.M. van Wijk, Dinny H. de Bakker, Johan van der Lei, and Maureen P.M.H. Rutten-van Mölken

Cost Consequences of Implementing an Electronic Decision Support System for Ordering Laboratory Tests in Primary Care: Evidence from a Controlled Prospective Study in The Netherlands
Clin Chem 2007 53: 213-219. Published online December 21, 2006; 10.1373/clinchem.2006.073908 [Abstract] [Full Text] [PDF] 073908.Supplemental Data  

Peter A. Kavsak, Alice M. Newman, Viliam Lustig, Andrew R. MacRae, Glenn E. Palomaki, Dennis T. Ko, Jack V. Tu, and Allan S. Jaffe

Long-Term Health Outcomes Associated with Detectable Troponin I Concentrations
Clin Chem 2007 53: 220-227. Published online January 4, 2007; 10.1373/clinchem.2006.076885 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Laura Sabatini, Michela Torricelli, Valentina Scaccia, Daniela Fineschi, Monica Pescaglini, Laura Gasparri, Pasquale Florio, and Felice Petraglia

Increased Plasma Concentrations of Antiprothrombin Antibodies in Women with Recurrent Spontaneous Abortions
Clin Chem 2007 53: 228-232. Published online December 7, 2006; 10.1373/clinchem.2006.073098 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Thomas Steuber, Andrew J. Vickers, Angel M. Serio, Ville Vaisanen, Alexander Haese, Kim Pettersson, James A. Eastham, Peter T. Scardino, Hartwig Huland, and Hans Lilja

Comparison of Free and Total Forms of Serum Human Kallikrein 2 and Prostate-Specific Antigen for Prediction of Locally Advanced and Recurrent Prostate Cancer
Clin Chem 2007 53: 233-240. Published online December 21, 2006; 10.1373/clinchem.2006.074963 [Abstract] [Full Text] [PDF]  

William C.S. Cho, Timothy T.C. Yip, Roger K.C. Ngan, Tai-Tung Yip, Vladimir N. Podust, Christine Yip, Harry H.Y. Yiu, Victor Yip, Wai-Wai Cheng, Victor W.S. Ma, and Stephen C.K. Law

ProteinChip Array Profiling for Identification of Disease- and Chemotherapy-Associated Biomarkers of Nasopharyngeal Carcinoma
Clin Chem 2007 53: 241-250. Published online January 2, 2007; 10.1373/clinchem.2005.065805 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Debajit Sircar and Papasani V. Subbaiah

Isoprostane Measurement in Plasma and Urine by Liquid Chromatography–Mass Spectrometry with One-Step Sample Preparation
Clin Chem 2007 53: 251-258. Published online January 2, 2007; 10.1373/clinchem.2006.074989 [Abstract] [Full Text] [PDF] 074989.Supplemental Data  

Hematology:

Patricia Álvarez, Pilar Sáenz, David Arteta, Antonio Martínez, Miguel Pocoví, Laureano Simón, and Pilar Giraldo

Transcriptional Profiling of Hematologic Malignancies with a Low-Density DNA Microarray
Clin Chem 2007 53: 259-267. Published online December 21, 2006; 10.1373/clinchem.2006.075887 [Abstract] [Full Text] [PDF] 075887.Supplemental Data  

Endocrinology and Metabolism:

Jacques J. Willemsen, H. Alec Ross, Jacques W.M. Lenders, and Fred C.G.J. Sweep

Stability of Urinary Fractionated Metanephrines and Catecholamines during Collection, Shipment, and Storage of Samples
Clin Chem 2007 53: 268-272. Published online December 7, 2006; 10.1373/clinchem.2006.075218 [Abstract] [Full Text] [PDF]  

Andreas Meinitzer, Ursula Seelhorst, Britta Wellnitz, Gabriele Halwachs-Baumann, Bernhard O. Boehm, Bernhard R. Winkelmann, and Winfried März

Asymmetrical Dimethylarginine Independently Predicts Total and Cardiovascular Mortality in Individuals with Angiographic Coronary Artery Disease (The Ludwigshafen Risk and Cardiovascular Health Study)
Clin Chem 2007 53: 273-283. Published online December 21, 2006; 10.1373/clinchem.2006.076711 [Abstract] [Full Text] [PDF]  

Tibor Kempf, Rüdiger Horn-Wichmann, Georg Brabant, Timo Peter, Tim Allhoff, Gunnar Klein, Helmut Drexler, Nina Johnston, Lars Wallentin, and Kai C. Wollert

Circulating Concentrations of Growth-Differentiation Factor 15 in Apparently Healthy Elderly Individuals and Patients with Chronic Heart Failure as Assessed by a New Immunoradiometric Sandwich Assay
Clin Chem 2007 53: 284-291. Published online December 21, 2006; 10.1373/clinchem.2006.076828 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Mireia Urpi-Sarda, Raul Zamora-Ros, Rosa Lamuela-Raventos, Antonio Cherubini, Olga Jauregui, Rafael de la Torre, Maria Isabel Covas, Ramon Estruch, Walter Jaeger, and Cristina Andres-Lacueva

HPLC–Tandem Mass Spectrometric Method to Characterize Resveratrol Metabolism in Humans
Clin Chem 2007 53: 292-299. Published online December 14, 2006; 10.1373/clinchem.2006.071936 [Abstract] [Full Text] [PDF]  

Elisabeth Leere Øiestad, Unni Johansen, and Asbjorg Solberg Christophersen

Drug Screening of Preserved Oral Fluid by Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2007 53: 300-309. Published online December 7, 2006; 10.1373/clinchem.2006.074237 [Abstract] [Full Text] [PDF] 074237.Supplemental data  

Richard W. Browne, Stephen T. Koury, Susan Marion, Gregory Wilding, Paola Muti, and Maurizio Trevisan

Accuracy and Biological Variation of Human Serum Paraoxonase 1 Activity and Polymorphism (Q192R) by Kinetic Enzyme Assay
Clin Chem 2007 53: 310-317. Published online December 21, 2006; 10.1373/clinchem.2006.074559 [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Mark W. Gorman, Eric O. Feigl, and Charles W. Buffington

Human Plasma ATP Concentration
Clin Chem 2007 53: 318-325. Published online December 21, 2006; 10.1373/clinchem.2006.076364 [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Rima Obeid, Panagiotis Kostopoulos, Jean-Pierre Knapp, Mariz Kasoha, George Becker, Klaus Fassbender, and Wolfgang Herrmann

Biomarkers of Folate and Vitamin B₁₂ Are Related in Blood and Cerebrospinal Fluid
Clin Chem 2007 53: 326-333. Published online January 2, 2007; 10.1373/clinchem.2006.076448 [Abstract] [Full Text] [PDF] 076448.Supplemental Data  

Clinical Immunology:

Alexander Buhl, Jochen H. Metzger, Niels H. H. Heegaard, Philipp von Landenberg, Martin Fleck, and Peter B. Luppa

Novel Biosensor–Based Analytic Device for the Detection of Anti–Double-Stranded DNA Antibodies
Clin Chem 2007 53: 334-341. Published online December 21, 2006; 10.1373/clinchem.2006.077339 [Abstract] [Full Text] [PDF] 077339.Supplemental Data  

Other Areas of Clinical Chemistry:

Gerd Rundström, Ann Jonsson, Ola Mårtensson, Ib Mendel-Hartvig, and Per Venge

Lateral Flow Immunoassay Using Europium (III) Chelate Microparticles and Time-Resolved Fluorescence for Eosinophils and Neutrophils in Whole Blood
Clin Chem 2007 53: 342-348. Published online December 21, 2006; 10.1373/clinchem.2006.074021 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Marina L. Kennerson, Trent Warburton, Eva Nelis, Megan Brewer, Patsie Polly, Peter De Jonghe, Vincent Timmerman, and Garth A. Nicholson

Mutation Scanning the GJB1 Gene with High-Resolution Melting Analysis: Implications for Mutation Scanning of Genes for Charcot-Marie-Tooth Disease
Clin Chem 2007 53: 349-352. Published online January 2, 2007; 10.1373/clinchem.2006.080010 [Abstract] [Full Text] [PDF]  

Jacques W.M. Lenders, Jacques J. Willemsen, Graeme Eisenhofer, H. Alec Ross, Karel Pacak, Henri J.L.M. Timmers, and C.G.J. (Fred) Sweep

Is Supine Rest Necessary before Blood Sampling for Plasma Metanephrines?
Clin Chem 2007 53: 352-354. Published online January 2, 2007; 10.1373/clinchem.2006.076489 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Esther Jensen, Ole Blaabjerg, Per Hyltoft Petersen, and Laszlo Hegedüs

Sampling Time Is Important but May Be Overlooked in Establishment and Use of Thyroid-Stimulating Hormone Reference Intervals
Clin Chem 2007 53: 355-356. [Extract] [Full Text] [PDF]  

Mayumi Saeki, Yoshiro Saito, Kimie Sai, Keiko Maekawa, Nahoko Kaniwa, Jun-ichi Sawada, Manabu Kawamoto, Akira Saito, and Naoyuki Kamatani

A Combinatorial Haplotype of the UDP-Glucuronosyltransferase 1A1 Gene (^#60-^#IB) Increases Total Bilirubin Concentrations in Japanese Volunteers
Clin Chem 2007 53: 356-358. [Extract] [Full Text] [PDF] 077990.Supplemental Data  

Nicole Reisch, Martin Reincke, and Martin Bidlingmaier

Preanalytical Stability of Adrenocorticotropic Hormone Depends on Time to Centrifugation Rather than Temperature
Clin Chem 2007 53: 358-359. [Extract] [Full Text] [PDF]  

Lorin M. Henrich, David E. Bruns, Doris M. Haverstick, Victoria G. Reynolds, and James C. Boyd

Indican Interference in Bilirubin Assays: A Classical Solution Still Applies
Clin Chem 2007 53: 359-361. [Extract] [Full Text] [PDF]  

Tom Teerlink and Peter G. Scheffer

LDL Particles Are Nonspherical: Consequences for Size Determination and Phenotypic Classification
Clin Chem 2007 53: 361-362. [Extract] [Full Text] [PDF]  

Edmond S.K. Ma and Ernest T.K. Lee

A Case of IgM Paraproteinemia in Which Serum Free Light Chain Values Were Within Reference Intervals
Clin Chem 2007 53: 362-363. [Extract] [Full Text] [PDF]  

Fidaa Ibrahim, Christine Parmentier, and Philippe Boudou

Divergence in Classification of 25-Hydroxyvitamin D Status with Respect to Immunoassays
Clin Chem 2007 53: 363-364. [Extract] [Full Text] [PDF]  

Johannes M.W. van den Ouweland and Stephan Church

High Total Protein Impairs Appropriate Gel Barrier Formation in BD Vacutainer Blood Collection Tubes
Clin Chem 2007 53: 364-365. [Extract] [Full Text] [PDF]  

Terho Lehtimäki, Antti Hervonen, Riikka Rontu, Pekka Karhunen, Marja Jylhä, and Mikko Hurme

Survival Related to Plasma C-Reactive-Protein in Nonagenarians Is Modified by Apolipoprotein E Genotype
Clin Chem 2007 53: 365-367. [Extract] [Full Text] [PDF]  

Ralph Carmel

Haptocorrin (Transcobalamin I) and Cobalamin Deficiencies
Clin Chem 2007 53: 367-368. [Extract] [Full Text] [PDF]  

Anne L. Morkbak and Ebba Nexø

The authors of the article cited above respond:
Clin Chem 2007 53: 368-369. [Extract] [Full Text] [PDF]  

Veronique Stove, Birgitte Wuyts, and Joris Delanghe

Perchloric Acid Treatment To Stabilize Uric Acid Concentrations in Blood Samples of Patients Receiving Uric Acid Oxidase (Rasburicase) Therapy
Clin Chem 2007 53: 369-370. [Extract] [Full Text] [PDF]  

Laura J. Owen and Brian G. Keevil

Does Bilirubin Cause Interference in Roche Creatinine Methods?
Clin Chem 2007 53: 370-371. [Extract] [Full Text] [PDF] 075846.Supplemental data  

Book, Software, and Web Site Reviews:

Dede Haverstick

Pharmaceutical Toxicology. Gerald J. Mulder, Lennart Dencker, eds. London: Pharmaceutical Press, 2006, 280 pp., $49.95, paperback. ISBN 0-85369-593-8.
Clin Chem 2007 53: 372. [Extract] [Full Text] [PDF]  

Obituary:

Steven H. Wong, Jonathan Sunshine, and Bradford R. Hepler

In Memoriam: Irving Sunshine, PhD DABFT, DABCC (1910–2006)
Clin Chem 2007 53: 373-374. [Extract] [Full Text] [PDF]  

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