Opinion:

Joris R. Delanghe, Michel R. Langlois, Marc L. De Buyzere, and Mathieu A. Torck

Vitamin C Deficiency and Scurvy Are Not Only a Dietary Problem but Are Codetermined by the Haptoglobin Polymorphism
Clin Chem 2007 53: 1397-1400. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Malin Ida Linnea Sjöholm, Joakim Dillner, and Joyce Carlson

Assessing Quality and Functionality of DNA from Fresh and Archival Dried Blood Spots and Recommendations for Quality Control Guidelines
Clin Chem 2007 53: 1401-1407. Published online June 22, 2007; 10.1373/clinchem.2007.087510 [Abstract] [Full Text] [PDF]  

Philippe Laurent, Karin Le Roux, Philippe Grivard, Gérard Bertil, Florence Naze, Miguel Picard, Frédérik Staikowsky, Georges Barau, Isabelle Schuffenecker, and Alain Michault

Development of a Sensitive Real-Time Reverse Transcriptase PCR Assay with an Internal Control to Detect and Quantify Chikungunya Virus
Clin Chem 2007 53: 1408-1414. Published online June 22, 2007; 10.1373/clinchem.2007.086595 [Abstract] [Full Text] [PDF] 086595.Supplemental Data  

Evidence-Based Laboratory Medicine and Test Utilization:

Tobias Breidthardt, Kirsten Laule, Anne-Henny Strohmeyer, Christian Schindler, Sophie Meier, Michael Fischer, André Scholer, Markus Noveanu, Michael Christ, André P. Perruchoud, and Christian Mueller

Medical and Economic Long-term Effects of B-Type Natriuretic Peptide Testing in Patients with Acute Dyspnea
Clin Chem 2007 53: 1415-1422. Published online June 22, 2007; 10.1373/clinchem.2006.081448 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Julie L.V. Shaw and Eleftherios P. Diamandis

Distribution of 15 Human Kallikreins in Tissues and Biological Fluids
Clin Chem 2007 53: 1423-1432. Published online June 15, 2007; 10.1373/clinchem.2007.088104 [Abstract] [Full Text] [PDF] 088104.Supplemental Data  

Cancer Diagnostics:

Eleni Zygalaki, Emily G. Tsaroucha, Loukas Kaklamanis, and Evi S. Lianidou

Quantitative Real-Time Reverse Transcription–PCR Study of the Expression of Vascular Endothelial Growth Factor (VEGF) Splice Variants and VEGF Receptors (VEGFR-1 and VEGFR-2) in Non–Small Cell Lung Cancer
Clin Chem 2007 53: 1433-1439. Published online June 28, 2007; 10.1373/clinchem.2007.086819 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Karl Winkler, Michael M. Hoffmann, Bernhard R. Winkelmann, Isolde Friedrich, Günther Schäfer, Ursula Seelhorst, Britta Wellnitz, Heinrich Wieland, Bernhard O. Boehm, and Winfried März

Lipoprotein-Associated Phospholipase A₂ Predicts 5-Year Cardiac Mortality Independently of Established Risk Factors and Adds Prognostic Information in Patients with Low and Medium High-Sensitivity C-Reactive Protein (The Ludwigshafen Risk and Cardiovascular Health Study)
Clin Chem 2007 53: 1440-1447. Published online June 15, 2007; 10.1373/clinchem.2007.086298 [Abstract] [Full Text] [PDF]  

Hematology:

Yvonne A. Daniel, Charles Turner, Roberta M. Haynes, Beverley J. Hunt, and R. Neil Dalton

Quantification of Hemoglobin A₂ by Tandem Mass Spectrometry
Clin Chem 2007 53: 1448-1454. Published online June 7, 2007; 10.1373/clinchem.2007.088682 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Markus Herrmann, Britt Wildemann, Lutz Claes, Stefan Klohs, Michael Ohnmacht, Omid Taban-Shomal, Ulrich Hübner, Anette Pexa, Natalia Umanskaya, and Wolfgang Herrmann

Experimental Hyperhomocysteinemia Reduces Bone Quality in Rats
Clin Chem 2007 53: 1455-1461. Published online June 22, 2007; 10.1373/clinchem.2007.086272 [Abstract] [Full Text] [PDF]  

Diego Rodríguez-Cabaleiro, Katleen Van Uytfanghe, Veronique Stove, Tom Fiers, and Linda M. Thienpont

Pilot Study for the Standardization of Insulin Immunoassays with Isotope Dilution–Liquid Chromatography/Tandem Mass Spectrometry
Clin Chem 2007 53: 1462-1469. Published online June 22, 2007; 10.1373/clinchem.2007.088393 [Abstract] [Full Text] [PDF]  

Mishaela R. Rubin, Shonni J. Silverberg, Pierre D’Amour, Jean-Hugues Brossard, Louise Rousseau, James Sliney, Jr, Tom Cantor, and John P. Bilezikian

An N-Terminal Molecular Form of Parathyroid Hormone (PTH) Distinct from hPTH(1–84) Is Overproduced in Parathyroid Carcinoma
Clin Chem 2007 53: 1470-1476. Published online June 28, 2007; 10.1373/clinchem.2007.085506 [Abstract] [Full Text] [PDF]  

George Mastorakos, Georgios Valsamakis, Dimitrios C. Papatheodorou, Ioannis Barlas, Alexandra Margeli, Anastasios Boutsiadis, Evangelia Kouskouni, Nikolaos Vitoratos, Apostolos Papadimitriou, Ioannis Papassotiriou, and George Creatsas

The Role of Adipocytokines in Insulin Resistance in Normal Pregnancy: Visfatin Concentrations in Early Pregnancy Predict Insulin Sensitivity
Clin Chem 2007 53: 1477-1483. Published online June 22, 2007; 10.1373/clinchem.2006.084731 [Abstract] [Full Text] [PDF]  

Christoph Schmid, Pierre-Alexandre Krayenbuehl, René-Ludwig Bernays, Cornelia Zwimpfer, Friedrich E. Maly, and Peter Wiesli

Growth Hormone (GH) Receptor Isoform in Acromegaly: Lower Concentrations of GH but Not Insulin-Like Growth Factor-1 in Patients with a Genomic Deletion of Exon 3 in the GH Receptor Gene
Clin Chem 2007 53: 1484-1488. Published online June 15, 2007; 10.1373/clinchem.2007.085712 [Abstract] [Full Text] [PDF] 085712.Supplemental Data  

Automation and Analytical Techniques:

Rama Sethuraman, Malathi G. Krishnamoorthy, Tat-Leang Lee, Eugene Hern C. Liu, Siau Chiang, Wataru Nishimura, Masato Sakai, Toshiaki Minami, and Shinro Tachibana

Simultaneous Analysis of D- and L-Serine in Cerebrospinal Fluid by Use of HPLC
Clin Chem 2007 53: 1489-1494. Published online June 22, 2007; 10.1373/clinchem.2007.086702 [Abstract] [Full Text] [PDF] 086702.Supplemental Data  

Jie Wu, Feng Yan, Jinhai Tang, Chun Zhai, and Huangxian Ju

A Disposable Multianalyte Electrochemical Immunosensor Array for Automated Simultaneous Determination of Tumor Markers
Clin Chem 2007 53: 1495-1502. Published online June 28, 2007; 10.1373/clinchem.2007.086975 [Abstract] [Full Text] [PDF] 086975.Supplemental data  

Ye Xu and Qingge Li

Multiple Fluorescent Labeling of Silica Nanoparticles with Lanthanide Chelates for Highly Sensitive Time-Resolved Immunofluorometric Assays
Clin Chem 2007 53: 1503-1510. Published online June 7, 2007; 10.1373/clinchem.2006.078485 [Abstract] [Full Text] [PDF] 078485.Supplemental Data  

General Clinical Chemistry:

Christopher R. deFilippi, Stephen L. Seliger, Susan Maynard, and Robert H. Christenson

Impact of Renal Disease on Natriuretic Peptide Testing for Diagnosing Decompensated Heart Failure and Predicting Mortality
Clin Chem 2007 53: 1511-1519. Published online June 22, 2007; 10.1373/clinchem.2006.084533 [Abstract] [Full Text] [PDF]  

Jacoline W. Brinkman, Dick de Zeeuw, Hiddo J. Lambers Heerspink, Ronald T. Gansevoort, Ido P. Kema, Paul E. de Jong, and Stephan J.L. Bakker

Apparent Loss of Urinary Albumin during Long-term Frozen Storage: HPLC vs Immunonephelometry
Clin Chem 2007 53: 1520-1526. Published online June 15, 2007; 10.1373/clinchem.2007.088823 [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Nicola Bizzaro, Elio Tonutti, Renato Tozzoli, and Danilo Villalta

Analytical and Diagnostic Characteristics of 11 2nd- and 3rd-Generation Immunoenzymatic Methods for the Detection of Antibodies to Citrullinated Proteins
Clin Chem 2007 53: 1527-1533. Published online June 22, 2007; 10.1373/clinchem.2007.087569 [Abstract] [Full Text] [PDF]  

Pediatric Clinical Chemistry:

Alison Woodworth, Jennifer Moore, Christopher G’Sell, Abraham Verdoes, Jennifer A. Snyder, Lee Morris, Catherine Wares, David G. Grenache, and Ann M. Gronowski

Diagnostic Accuracy of Cervicovaginal Interleukin-6 and Interleukin-6:Albumin Ratio as Markers of Preterm Delivery
Clin Chem 2007 53: 1534-1540. Published online June 7, 2007; 10.1373/clinchem.2007.084798 [Abstract] [Full Text] [PDF] 084798.Supplemental Data  

Technical Briefs:

Hiroyuki Ebinuma, Takashi Miida, Toshimasa Yamauchi, Yusuke Hada, Kazuo Hara, Naoto Kubota, and Takashi Kadowaki

Improved ELISA for Selective Measurement of Adiponectin Multimers and Identification of Adiponectin in Human Cerebrospinal Fluid
Clin Chem 2007 53: 1541-1544. Published online June 28, 2007; 10.1373/clinchem.2007.085654 [Abstract] [Full Text] [PDF]  

Mark G. Herrmann, Jacob D. Durtschi, Carl T. Wittwer, and Karl V. Voelkerding

Expanded Instrument Comparison of Amplicon DNA Melting Analysis for Mutation Scanning and Genotyping
Clin Chem 2007 53: 1544-1548. Published online June 7, 2007; 10.1373/clinchem.2007.088120 [Abstract] [Full Text] [PDF]  

Case Report:

Lorenzo Dolcini, Gianluca Caridi, Monica Dagnino, Alberto Sala, Selim Gökçe, Semra Sökücü, Monica Campagnoli, Monica Galliano, and Lorenzo Minchiotti

Analbuminemia Produced by a Novel Splicing Mutation
Clin Chem 2007 53: 1549-1552. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Giuseppe Lippi, Mario Plebani, and Gian Cesare Guidi

The Paradox in Translational Medicine
Clin Chem 2007 53: 1553. [Extract] [Full Text] [PDF]  

Christiaan S. van Woerden, Jaap W. Groothoff, Frits A. Wijburg, Hans R. Waterham, Ronald J.A. Wanders, Marcel J.W. Janssen, and Marinus Duran

Primary Hyperoxaluria Remains Undiagnosed in Patients with Hyperoxaluria and Recurrent Urolithiasis
Clin Chem 2007 53: 1553-1555. [Extract] [Full Text] [PDF]  

Steve Kitchen, Dianne Kitchen, Ian Jennings, Tim Woods, and Isobel Walker

Quality Assessment of CoaguChek Point-of-Care International Normalized Ratio Monitors: A Note of Caution
Clin Chem 2007 53: 1555-1556. [Extract] [Full Text] [PDF]  

Leon Poller, Jørgen Jespersen, Michelle Keown, Saied Ibrahim, and Armando Tripodi

The authors of the article cited above respond:
Clin Chem 2007 53: 1556-1557. [Extract] [Full Text] [PDF]  

Diego Franciotta and Francesco Lolli

Interlaboratory Reproducibility of Isoelectric Focusing in Oligoclonal Band Detection
Clin Chem 2007 53: 1557-1558. [Extract] [Full Text] [PDF]  

Fred S. Apple and MaryAnn M. Murakami

Serum and Plasma Cardiac Troponin I 99th Percentile Reference Values for 3 2nd-Generation Assays
Clin Chem 2007 53: 1558-1560. [Extract] [Full Text] [PDF]  

Anna Lempiäinen, Kristina Hotakainen, Carl Blomqvist, Henrik Alfthan, and Ulf-Håkan Stenman

Increased Human Chorionic Gonadotropin Due to Hypogonadism after Treatment of a Testicular Seminoma
Clin Chem 2007 53: 1560-1561. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

David E. Bruns

The Clinical Chemist
Clin Chem 2007 53: 1562-1564. [Extract] [Full Text] [PDF]  

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