Editorials:

Nader Rifai

Clinical Chemistry: A Glimpse into the Future
Clin Chem 2008 54: 1-2. [Extract] [Full Text] [PDF]  

Lance A. Liotta and Emanuel F. Petricoin

Putting the "Bio" back into Biomarkers: Orienting Proteomic Discovery toward Biology and away from the Measurement Platform
Clin Chem 2008 54: 3-5. [Extract] [Full Text] [PDF]  

Rosamonde E. Banks

Preanalytical Influences in Clinical Proteomic Studies: Raising Awareness of Fundamental Issues in Sample Banking
Clin Chem 2008 54: 6-7. [Extract] [Full Text] [PDF]  

Stephen O. Brennan

Fifty-Eight Years of Hemoglobin Analysis
Clin Chem 2008 54: 8-10. [Extract] [Full Text] [PDF]  

Perspectives:

Paul M Ridker

Fasting versus Nonfasting Triglycerides and the Prediction of Cardiovascular Risk: Do We Need to Revisit the Oral Triglyceride Tolerance Test?
Clin Chem 2008 54: 11-13. Published online November 12, 2007; 10.1373/clinchem.2007.097907 [Extract] [Full Text] [PDF]  

G. Russell Warnick and Katsuyuki Nakajima

Fasting versus Nonfasting Triglycerides: Implications for Laboratory Measurements
Clin Chem 2008 54: 14-16. Published online November 26, 2007; 10.1373/clinchem.2007.098863 [Extract] [Full Text] [PDF]  

Mini-Review:

Nancy R. Cook

Statistical Evaluation of Prognostic versus Diagnostic Models: Beyond the ROC Curve
Clin Chem 2008 54: 17-23. Published online November 16, 2007; 10.1373/clinchem.2007.096529 [Abstract] [Full Text] [PDF]  

Review:

René R. S. Packard and Peter Libby

Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction
Clin Chem 2008 54: 24-38. [Abstract] [Full Text] [PDF]  

Opinion:

Pieter Vermeersch, Koenraad Gijbels, Godelieve Mariën, Rod Lunn, William Egner, Peter White, and Xavier Bossuyt

A Critical Appraisal of Current Practice in the Detection, Analysis, and Reporting of Cryoglobulins
Clin Chem 2008 54: 39-43. Published online November 12, 2007; 10.1373/clinchem.2007.090134 [Abstract] [Full Text] [PDF] Data Supplement  

Proteomics and Protein Markers:

Dale McLerran, William E. Grizzle, Ziding Feng, William L. Bigbee, Lionel L. Banez, Lisa H. Cazares, Daniel W. Chan, Jose Diaz, Elzbieta Izbicka, Jacob Kagan, David E. Malehorn, Gunjan Malik, Denise Oelschlager, Alan Partin, Timothy Randolph, Nicole Rosenzweig, Shiv Srivastava, Sudhir Srivastava, Ian M. Thompson, Mark Thornquist, Dean Troyer, Yutaka Yasui, Zhen Zhang, Liu Zhu, and O. John Semmes

Analytical Validation of Serum Proteomic Profiling for Diagnosis of Prostate Cancer: Sources of Sample Bias
Clin Chem 2008 54: 44-52. Published online November 2, 2007; 10.1373/clinchem.2007.091470 [Abstract] [Full Text] [PDF]  

Dale McLerran, William E. Grizzle, Ziding Feng, Ian M. Thompson, William L. Bigbee, Lisa H. Cazares, Daniel W. Chan, Jackie Dahlgren, Jose Diaz, Jacob Kagan, Daniel W. Lin, Gunjan Malik, Denise Oelschlager, Alan Partin, Timothy W. Randolph, Lori Sokoll, Shiv Srivastava, Sudhir Srivastava, Mark Thornquist, Dean Troyer, George L. Wright, Zhen Zhang, Liu Zhu, and O. John Semmes

SELDI-TOF MS Whole Serum Proteomic Profiling with IMAC Surface Does Not Reliably Detect Prostate Cancer
Clin Chem 2008 54: 53-60. Published online November 16, 2007; 10.1373/clinchem.2007.091496 [Abstract] [Full Text] [PDF] Supplement Data  

Denis Sviridov, Steven K. Drake, and Glen L. Hortin

Reactivity of Urinary Albumin (Microalbumin) Assays with Fragmented or Modified Albumin
Clin Chem 2008 54: 61-68. Published online November 2, 2007; 10.1373/clinchem.2007.092825 [Abstract] [Full Text] [PDF]  

Hematology:

Peter Kleinert, Marlis Schmid, Karin Zurbriggen, Oliver Speer, Markus Schmugge, Bernd Roschitzki, Silke S. Durka, Urs Leopold, Thomas Kuster, Claus W. Heizmann, Hannes Frischknecht, and Heinz Troxler

Mass Spectrometry: A Tool for Enhanced Detection of Hemoglobin Variants
Clin Chem 2008 54: 69-76. Published online October 11, 2007; 10.1373/clinchem.2007.089961 [Abstract] [Full Text] [PDF] Supplement Data  

Srinivas D. Narasipura, Joel C. Wojciechowski, Nichola Charles, Jane L. Liesveld, and Michael R. King

P-Selectin–Coated Microtube for Enrichment of CD34⁺ Hematopoietic Stem and Progenitor Cells from Human Bone Marrow
Clin Chem 2008 54: 77-85. Published online November 16, 2007; 10.1373/clinchem.2007.089896 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Anna Söderlund-Strand, Joakim Dillner, and Joyce Carlson

High-Throughput Genotyping of Oncogenic Human Papilloma Viruses with MALDI-TOF Mass Spectrometry
Clin Chem 2008 54: 86-92. Published online November 2, 2007; 10.1373/clinchem.2007.092627 [Abstract] [Full Text] [PDF]  

Celia Pérez-Cerdá, Dulce Quelhas, Ana I. Vega, Jesús Ecay, Laura Vilarinho, and Magdalena Ugarte

Screening Using Serum Percentage of Carbohydrate-Deficient Transferrin for Congenital Disorders of Glycosylation in Children with Suspected Metabolic Disease
Clin Chem 2008 54: 93-100. Published online November 16, 2007; 10.1373/clinchem.2007.093450 [Abstract] [Full Text] [PDF]  

Janke Prins, Brenda B. van der Meijden, Rob J. Kraaijenhagen, and Jos P.M. Wielders

Inherited Chronic Obstructive Pulmonary Disease: New Selective-Sequencing Workup for ₁-Antitrypsin Deficiency Identifies 2 Previously Unidentified Null Alleles
Clin Chem 2008 54: 101-107. Published online November 16, 2007; 10.1373/clinchem.2007.095125 [Abstract] [Full Text] [PDF]  

Michael T. Seipp, David Pattison, Jacob D. Durtschi, Mohamed Jama, Karl V. Voelkerding, and Carl T. Wittwer

Quadruplex Genotyping of F5, F2, and MTHFR Variants in a Single Closed Tube by High-Resolution Amplicon Melting
Clin Chem 2008 54: 108-115. Published online November 2, 2007; 10.1373/clinchem.2007.097121 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Zhiliang Jiang, Wenxing Huang, Jiangping Li, Mingshun Li, Aihui Liang, Shengsen Zhang, and Bing Chen

Nanogold Catalysis–Based Immunoresonance-Scattering Spectral Assay for Trace Complement Component 3
Clin Chem 2008 54: 116-123. Published online November 12, 2007; 10.1373/clinchem.2007.091801 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Natalie Khuseyinova, Sonja Greven, Regina Rückerl, Gerlinde Trischler, Hannelore Loewel, Annette Peters, and Wolfgang Koenig

Variability of Serial Lipoprotein-Associated Phospholipase A₂ Measurements in Post–Myocardial Infarction Patients: Results from the AIRGENE Study Center Augsburg
Clin Chem 2008 54: 124-130. Published online November 16, 2007; 10.1373/clinchem.2007.093468 [Abstract] [Full Text] [PDF] Supplement Data  

Yu-Ting Chang, Ming-Chu Chang, Ta-Chen Su, Po-Chin Liang, Yi-Ning Su, Chun-Hung Kuo, Shu-Chen Wei, and Jau-Min Wong

Association of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutation/Variant/Haplotype and Tumor Necrosis Factor (TNF) Promoter Polymorphism in Hyperlipidemic Pancreatitis
Clin Chem 2008 54: 131-138. Published online November 2, 2007; 10.1373/clinchem.2007.093492 [Abstract] [Full Text] [PDF]  

Isabella Kardys, Nader Rifai, Olivier Meilhac, Jean-Baptiste Michel, Jose Luis Martin-Ventura, Julie E. Buring, Peter Libby, and Paul M Ridker

Plasma Concentration of Heat Shock Protein 27 and Risk of Cardiovascular Disease: A Prospective, Nested Case-Control Study
Clin Chem 2008 54: 139-146. Published online November 16, 2007; 10.1373/clinchem.2007.094961 [Abstract] [Full Text] [PDF]  

Roya Kelishadi, Mohammad Hashemi, Noushin Mohammadifard, Sedigheh Asgary, and Noushin Khavarian

Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function after a Lifestyle Modification Trial Among Obese Children
Clin Chem 2008 54: 147-153. Published online November 12, 2007; 10.1373/clinchem.2007.089953 [Abstract] [Full Text] [PDF] Supplement data  

Edmond K. Kabagambe, Michael Y. Tsai, Paul N. Hopkins, Jose M. Ordovas, James M. Peacock, Ingrid B. Borecki, and Donna K. Arnett

Erythrocyte Fatty Acid Composition and the Metabolic Syndrome: A National Heart, Lung, and Blood Institute GOLDN Study
Clin Chem 2008 54: 154-162. Published online November 12, 2007; 10.1373/clinchem.2007.095059 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Chungang Yuan, Xiufen Lu, Nicole Oro, Zhongwen Wang, Yajuan Xia, Timothy J. Wade, Judy Mumford, and X. Chris Le

Arsenic Speciation Analysis in Human Saliva
Clin Chem 2008 54: 163-171. Published online November 2, 2007; 10.1373/clinchem.2007.092189 [Abstract] [Full Text] [PDF]  

Allan J. Barnes, Michael L. Smith, Sherri L. Kacinko, Eugene W. Schwilke, Edward J. Cone, Eric T. Moolchan, and Marilyn A. Huestis

Excretion of Methamphetamine and Amphetamine in Human Sweat Following Controlled Oral Methamphetamine Administration
Clin Chem 2008 54: 172-180. Published online November 2, 2007; 10.1373/clinchem.2007.092304 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Anna Cabré, Iolanda Lázaro, Josefa Girona, Josep M. Manzanares, Francesc Marimón, Núria Plana, Mercedes Heras, and Lluís Masana

Plasma Fatty Acid-Binding Protein 4 Increases with Renal Dysfunction in Type 2 Diabetic Patients without Microalbuminuria
Clin Chem 2008 54: 181-187. Published online November 16, 2007; 10.1373/clinchem.2007.094672 [Abstract] [Full Text] [PDF]  

Patrick Garnero, Philippe Vergnaud, and Nicholas Hoyle

Evaluation of a Fully Automated Serum Assay for Total N-Terminal Propeptide of Type I Collagen in Postmenopausal Osteoporosis
Clin Chem 2008 54: 188-196. Published online November 12, 2007; 10.1373/clinchem.2007.094953 [Abstract] [Full Text] [PDF]  

Brief Communications:

Zia Fazili, Christine M. Pfeiffer, Mindy Zhang, Ram B. Jain, and Deborah Koontz

Influence of 5,10-Methylenetetrahydrofolate Reductase Polymorphism on Whole-Blood Folate Concentrations Measured by LC-MS/MS, Microbiologic Assay, and Bio-Rad Radioassay
Clin Chem 2008 54: 197-201. [Abstract] [Full Text] [PDF] Supplement Data  

Pasquale Florio, Raul Abella, Emanuela Marinoni, Romolo Di Iorio, Claudio Letizia, Marco Meli, Teresa de la Torre, Felice Petraglia, Alessandro Cazzaniga, Alessandro Giamberti, Alessandro Frigiola, and Diego Gazzolo

Adrenomedullin Blood Concentrations in Infants Subjected to Cardiopulmonary Bypass: Correlation with Monitoring Parameters and Prediction of Poor Neurological Outcome
Clin Chem 2008 54: 202-206. Published online November 16, 2007; 10.1373/clinchem.2007.087700 [Abstract] [Full Text] [PDF] Supplemental Data  

Citation Classics:

Richard Wennberg

Unbound Bilirubin: A Better Predictor of Kernicterus?
Clin Chem 2008 54: 207-208. [Extract] [Full Text] [PDF]  

Clinical Case Study:

Christopher R. McCudden, Monte S. Willis, and David G. Grenache

Persistent Low Concentration of Human Chorionic Gonadotropin in a Nonpregnant Woman
Clin Chem 2008 54: 209-213. Published online November 16, 2007; 10.1373/clinchem.2007.092411 [Extract] [Full Text] [PDF]  

Commentaries:

Carolyn Y. Muller

Commentary
Clin Chem 2008 54: 213. [Extract] [Full Text] [PDF]  

Ulf-Håkan Stenman

Commentary
Clin Chem 2008 54: 213-214. [Extract] [Full Text] [PDF]  

Letters to the Editor:

David M. Parry

Use of Single-Value Protein Compensation of the Jaffe Creatinine Assay Contributes to Clinically Significant Inaccuracy in Results
Clin Chem 2008 54: 215-216. [Extract] [Full Text] [PDF]  

Peer de Graaf, Nanne K.H. de Boer, Bindia Jharap, Chris J.J. Mulder, Ad A. van Bodegraven, and Agnes I. Veldkamp

Stability of Thiopurine Metabolites: A Potential Analytical Bias
Clin Chem 2008 54: 216-218. [Extract] [Full Text] [PDF]  

Sarah Neale, Anne Brown, Jinny Jeffery, and Ruth M Ayling

Drug Monitoring and Toxicology (DMT)
Clin Chem 2008 54: 218-220. [Extract] [Full Text] [PDF]  

Gifford Lum, Barry Mushlin, and Linda Farney

False-Positive Rates for the Qualitative Analysis of Urine Benzodiazepines and Metabolites with the Reformulated Abbott Multigent^TM Reagents
Clin Chem 2008 54: 220-221. [Extract] [Full Text] [PDF]  

Ravinder J. Singh

Are Clinical Laboratories Prepared for Accurate Testing of 25-Hydroxy Vitamin D?
Clin Chem 2008 54: 221-223. [Extract] [Full Text] [PDF]  

Marita Dednam, Barend Christiaan Vorster, and Johan Bernard Ubbink

Biological Variation of Myeloperoxidase
Clin Chem 2008 54: 223-225. [Extract] [Full Text] [PDF]  

Soeren Junge Nielsen, Jens F. Rehfeld, and Jens Peter Goetze

Mismeasure of C-Type Natriuretic Peptide
Clin Chem 2008 54: 225-227. [Extract] [Full Text] [PDF]  

Patrizia Piccioli, Martina Serra, Simona Pedemonte, Giuseppe Balbi, Fabrizio Loiacono, Sonia Lastraioli, Lucia Gargiulo, Anna Morabito, Daniela Zuccaro, Lucia Del Mastro, Maria Pia Pistillo, Marco Venturini, Maria De Angioletti, and Rosario Notaro

Hexaprimer Amplification Refractory Mutation System PCR for Simultaneous Single-Tube Genotyping of 2 Close Polymorphisms
Clin Chem 2008 54: 227-229. [Extract] [Full Text] [PDF]  

Clinical Chemist:

Carl A. Burtis

David Bruns: An Editor for All Reasons
Clin Chem 2008 54: 230. [Extract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.